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Skin Rejuvenation by Novel Synthetic Compound Containing Retinoidal Activity  

Rho Ho Sik (Amore Pacific R&D Center)
Baek Heung Soo (Amore Pacific R&D Center)
Kim Sujong (Amore Pacific R&D Center)
Kim Sunam (Amore Pacific R&D Center)
Kim Duck Hee (Amore Pacific R&D Center)
Chang Ih Seop (Amore Pacific R&D Center)
Lee Ok-Sub (Amore Pacific R&D Center)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.30, no.3, 2004 , pp. 405-408 More about this Journal
Abstract
Several hydroxamic acid derivatives are synthesized to observe retinoidal effect and transactivation potential for $RAR{\alpha}/{\gamma]$ is screened. Among the synthesized compounds, N-(4-N-hydroxycarbamoyl )phenyl) [4-(tert-butyl )phenyl] carboxamide (2f) showed the best compatibility for potent $RAR{\alpha}/{\gamma].$ The acidic hydroxy of hydroxamic acid was easily deprotonated to form an enolate. A formed enolate has a similar role like that of all-trans-retinoic acid. This is the first example of the hydroxamic acid derivative with retinoidal activity. The retinoidal activity of 2f was further confirmed by enhancing activity for the expression of retinoid-responsive genes. To evaluate the possibility for anti.-aging agent, effect on the expression of MMP-1 was measured comparing with all-trans-retinoic acid and retinol. At 10 uM treatment, compound 2f inhibited the expression of MMP-1. These results suggest that new hydroxamic acid derivative 2f could be used as a promising anti-aging agent.
Keywords
hydroxanmic aid; retinoic aid; receptor; MMP-1; aging;
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