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The Study for Stability of Useful Glycyrrhiza uralensis (Licorice Root) Using Nanosolve and PMMA  

Ji, Hong-Geun (Department of Chemistry, Sungkyunkwan University)
Kim, Ju-Duck (Sookmyung Unversity)
Kim, Jeong-Dong (R&D Center, IPSE Cosmetics)
Choi, Jung-Sik (H & A PharmaChem)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.30, no.2, 2004 , pp. 207-210 More about this Journal
Abstract
Glycyrrhiza uralensis (licorice root) is very useful medicinal herb because of strong anti-inflammatory and anti-wrinkle effect. Therefore, it is widely used in functional cosmetics. However, it is insoluble and easily decomposed by light, heat, oxygen, etc. In this study, we first prepared NanoSolve-Licorice (30-50nm) using Glycyrrhiza uralensis and propylene glycol! hydrogenated lecithin/caprylic/capric triglyceride/glycerin/water system with microfluidizer. And then, NanoSolve-Licorice and porous PMMA are dispersed in ethanol. Finally, we could get a stabilized system with high-pressure homogenizer (1,000 Bar, 3 passes). According to HPLC measurement for glabridin content, our system is more stable compared with general liposome ones. Capsulated licorice has an enhanced anti-inflammatory effect on account of excellent skin penetration. We also evaluated our final product through image analyzer, particle size analyzer, FF-TEM and chromameter.
Keywords
Glycyrrhiza uralensis(licorice root); liposome; nano-emulsion; microfluidizer; PMMA(polymethylmethacrylate);
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