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Lamellar-bio nano-hybrid; The Study for Stability of Catechin (Green Tea: EGCG) Using 3-Dimensional Liposome  

Hong Geun, Ji (H&A Pharmachem)
Jung Sik, Choi (H&A Pharmachem)
Hee Suk, Kwon (R&D Center, Hankook Cosmo Cosmetics)
Sung Rack, Cho (R&D Center, Hankook Cosmo Cosmetics)
Byoung Kee, Jo (R&D Center, Coreana)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.30, no.2, 2004 , pp. 201-205 More about this Journal
Abstract
In these several years, as many people have been attracted by the functional cosmetics, there are a lot of study to enhance the stability of active ingredients for light, heat, oxygen, etc. in the academic and industrial field. Especially, catechin is well known as strong anti-oxidant, anti-inflammatory and reducing agent for oxidative stress but it is very unstable for light, heat, oxygen. etc. In this study, the stability and skin penetration of catechin are improved by 3-dimensional method. As I-dimension, porous silica is prepared using sol-gel method, and then catechin is adsorbed in pores of silica. As 2-dimension, solid lipid nanoparticles (SLN) are obtained using non-phospholipid vesicles. Finally 3-dimension is completion through lamellar phase self-organization that combines SLN catechin with skin lipid matrix. We used laser light scattering system, cyro-SEM, chromameter, HPLC and image analyzer to analyze our 3-dimentional systems. According to chromameter date, the color stability of 3-dimensional catechin is enhanced by 5-10 times compared with general liposome systems. We also confirmed through HPLC analysis that 3-dimensional catechin is more long lasting. The effect of skin penetration and wrinkle reduction are improved, too.
Keywords
catechin (green tea: EGCG); porous silica; SLN (solid lipid nano-particle); SLM (skin lipid matrix); 3-dimensional liposomes;
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