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Identification of Ozone-induced Skin Damage and Screening of Antioxidant for Ozone  

최신욱 ((주)래디안)
김창수 ((주)래디)
정재형 (강원대학교 생화학)
김남경 (강원대학교 생화학)
한상화 (강원대학교 생화학과)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.30, no.1, 2004 , pp. 39-51 More about this Journal
Abstract
Ozone(O$_3$), one of best-known toxic air pollutant, act as a strong oxidant. It is possible that skins exposed to the air can be easily damaged by such oxidative air pollutants. Therefore, in the present study, anti-oxidative effects of natural product. on $O_2$ㆍ and ㆍOH were investigated by EPR. Ozone caused protein damage and lipid oxidation, in HaCaT and B16F10 leading ultimately to programmed cell death. It also reduced the level of antioxidant molecules including ascorbic acid and tocopherol in stratum comeum. However, antioxidants originated from natural products could protect skin from these products could protect skin from these oxidative damages. We concluded that eight natural extracts including Rosa davurica, Ligularia sibrica, Green tea acted as strong antioxidants against ozone.
Keywords
ozone; free radical; antioxidants; skin damage; plant extracts;
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