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http://dx.doi.org/10.15432/JKTO.2016.21.2.063

A Case Report of Recurred Hepatocellular Carcinoma Patient Treated with Radio-Frequency Hyperthermia in Conjunction with Sorafenib  

Kim, Jee-Hye (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University)
Lee, Jong-Hoon (Integrative Cancer Center, Woosuk Korean Medicine Hospital of Woosuk University)
Joo, Jong-Cheon (Integrative Cancer Center, Jeonju Korean Medicine Hospital of Wonkwang University)
Lee, Jeong-Bok (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University)
Cho, Chong-Kwan (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University)
Yoo, Hwa-Seung (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University)
Publication Information
Journal of Korean Traditional Oncology / v.21, no.2, 2016 , pp. 63-74 More about this Journal
Abstract
Objective : The purpose of this study is to report the effects of radio-frequency hyperthermia cancer treatment in conjunction with Sorafenib on hepatocellular carcinoma patient. Method : The patient was diagnosed with hepatocellular carcinoma at S6/7 and treated with right posterior sectionectomy. After 4 months, tumor recurrence was found at S4, 5 and 8. After transarterial chemoembolization, the patient was prescribed Sorafenib (proprietary name $Nexavar^{(R)}$ ) as well as proceeding with radio-frequency hyperthermia. The clinical outcomes were measured by computed tomography, laboratory findings including tumor markers (AFP, PIVKA-II), natural killer (NK) cell activity, and numeric rating scales (NRS). Results : After the treatment, tumor size was decreased accompanying by reducing the level of tumor markers (AFP, PIVKA-II). Major clinical symptoms were improved with increasing NK cell activity. There were no adverse events based on National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0. Conclusion : This case suggests that radio-frequency hyperthermia has synergistic effect for the treatment of hepatocellular carcinoma patient in conjunction with Sorafenib.
Keywords
Hepatocellular carcinoma; Radio-frequency hyperthermia; Sorafenib; ${\alpha}-fetoprotein$; PIVKA-ll; Natural killer cell activity;
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