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http://dx.doi.org/10.7778/jpkm.2022.36.3.19

Effects of Paeoniae Radix, Glycyrrhiza Uralensis and Jakyakgamcho-tang Treatment on Ulcerative Colitis Animal Model: Including Changes in Metabolites  

Choi, Sun Hee (Haneulche Korean Medicine Clinic)
Park, Eun Jung (Department of Pediatric, College of Korean Medicine, Wonkwang University)
Publication Information
The Journal of Pediatrics of Korean Medicine / v.36, no.3, 2022 , pp. 19-34 More about this Journal
Abstract
Objectives To investigate the effect of Jakyakgamcho-tang (JGT) on Dextran sulfate sodium (DSS) induced ulcerative colitis. Methods Experimental animals were divided into six groups; group 1, normal group; group 2, DSS-induced colitis group; group 3, 5-aminosalicylic acid (5-ASA)-treated group; group 4, Glycyrrhiza Uralensis (Gamcho, GC)-treated group; group 5, Paeoniae Radix (Jakyak, JY)-treated group; group 6, JGT-treated group. Inflammatory cytokines and their metabolites were detected. Result In the JGT group, the levels of tumor necrosis factor alpha (TNF-α), prostaglandin E2 (PGE2) were significantly decreased, whereas that of Interleukin-10 (IL-10) were significantly increased. In addition, the metabolite profile changed in the JGT group with most metabolites increasing. Conclusion This study demonstrates that the therapeutic potential of JGT in ulcerative colitis. Further studies should be conducted to confirm our findings.
Keywords
Jakyakgamcho-tang; ulcerative colitis; cytokines; metabolomics; metabolites;
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Times Cited By KSCI : 3  (Citation Analysis)
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