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http://dx.doi.org/10.7778/jpkm.2021.35.1.40

Effect of Anti-Inflammation through Creation of Skin Fat Barrier on Scutellaria baicalensis extract  

Ahn, Sang Hyun (Dept. of anatomy, college of Korean Medicine, Semyung University)
Kim, Ki Bong (School of Korean Medicine, Pusan National University)
Publication Information
The Journal of Pediatrics of Korean Medicine / v.35, no.1, 2021 , pp. 40-47 More about this Journal
Abstract
Objectives The purpose of this study is to confirm the effect of alleviating inflammation through creating skin fat barrier from Scutellaria baicalensis extract. Methods Four-week-old Balb/C mice were divided into four groups: control group (Ctrl), lipid barrier eliminated group (LBEG), dexamethasone (DM) treated group after lipid barrier elimination (DMTG), and Scutellaria baicalensis (SB) treated group after lipid barrier elimination (SBTG). Scutellaria baicalensis extract were administered for 5 days after removal of the fat barrier. Changes in skin condition, improvement of the fat barrier, and relief of inflammation were observed in each group. Results Compared to LBEG and DMTG, pathological skin damage and tissue changes were less in SBTG, and transepidermal water loss (TEWL) and pH were also significantly reduced. Filaggrin was also significantly increased in SBTG. KLK7, PAR-2, and TSLP in SBTG also showed significant reduction compared to the LBEG and DMTG. Conclusions Scutellaria baicalensis extract restores skin barrier and relieves inflammation through the creation of skin fat barrier. This means that the Scutellaria baicalensis extract can regulate Th2 differentiation through the creation of the epithelial fat barrier.
Keywords
Scutellaria baicalensis; Skin Fat Barrier; Filaggrin; Inflammation;
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