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http://dx.doi.org/10.7778/jpkm.2021.35.1.30

The Anti-Inflammatory Effect of Duchi extract on Ulcerative Colitis  

Yang, Byeng Mok (School of Korean Medicine, Pusan National University)
Ahn, Sang Hyun (Dept. of anatomy, college of Korean Medicine, Semyung University)
Kim, Ki Bong (School of Korean Medicine, Pusan National University)
Publication Information
The Journal of Pediatrics of Korean Medicine / v.35, no.1, 2021 , pp. 30-39 More about this Journal
Abstract
Objective The purpose of this study is to learn the anti-inflammatory effect of Douchi on ulcerative colitis (UC). Methods Three-month-old mice were divided into 4 groups as follows: control group (Ctrl), UC induced group (UCEG), Pentasa treated group after inducing UC (OPTG), and Douchi treated group after inducing UC (FGTG). NF-κB, p-IκB, iNOS, COX-2 were observed by immunohistochemistry and Masson trichrome, PAS, and Phloxine-tartrazine staining were used to observe histochemical changes. Results Inflammation indicators of the large intestine were significantly lower in FGTG than in the UCEG and OPTG. Also, indicators involved in pulmonary alveolar formation were significantly higher in the FGTG than in the UCEG and OPTG. Conclusions The result of this study suggests that Douchi extract was effective in ulcerative colitis and helped in the formation of alveolar. This result suggests that the lungs and colon are correlated.
Keywords
Douchi; Ulcerative colitis; Inflammation; Large intestine;
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