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http://dx.doi.org/10.7778/jpkm.2020.34.4.43

A Review of the Experimental Studies on the Modulatory Effect Herbal Medicine on Gut Microbiota  

Ahn, Hye Ri (Department of Pediatrics, College of Korean Medicine, Daejeon University)
Song, Ji Hyun (Department of Pediatrics, College of Korean Medicine, Daejeon University)
Lee, Hye Lim (Department of Pediatrics, College of Korean Medicine, Daejeon University)
Publication Information
The Journal of Pediatrics of Korean Medicine / v.34, no.4, 2020 , pp. 43-58 More about this Journal
Abstract
Objectives The purpose of this study is to analyze the effect of various herbal medicin on gut microbiota. Methods Electronic searches were performed using NDSL, OASIS, KISS, KMBASE, K-portal, Pub med, Cochrane, CNKI. Results we analyzed 25 experimental studies on the effect of herbal medicine on microbiota. Diabetes, obesity, inflammatory bowel disease have been frequently studied in micobiota-related disease. The most common experimental animal model used in the studies C57BL/7 mouse. Among the studies wherein single herbal medication were used, Gynostemma pentaphyllum was most commonly studies, and different herbal medications were used in the studies wherein complex herbal medications were studied. Next generation sequencing was performed using Illumina MiSeq system, and gut microbiota analysis was performed using QIIME and Ribosomal Database Project (RDP). In most studies, the herbal medicines exerted regulatory effects on gut microbiota and improved the symptoms of the experimental groups. Conclusions This review provides basic data on the correlation between korean medicine and gut microbiota, as well as information for the development of korean medicine.
Keywords
Gut microbiota; Microbiome; Herbal medicine; Korean medicine; Experimental studies; Review;
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1 Human microbiome project consortium. A framework for human microbiome research. Nature. 2012;486:215-21.   DOI
2 Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N, Knight R. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA. 2010;107:11971-5.   DOI
3 Koenig JE, Spor A, Scalfone N, Fricker AD, Stombaugh J, Knight R, Angenent LT, Ley RE. Succession of microbial consortia in the developing infant gut microbiome. Proc Natl Acad Sci USA. 2011;108(Suppl 1):4578-85.   DOI
4 Lutgendorff F, Akkermans LM, Soderholm JD. The role of microbiota and probiotics in stress-induced gastro-intestinal damage. Curr Mol Med. 2008;8(4):282-98.   DOI
5 Kim Mj, Choin YR, Shin NR, Lee MJ, Kim HJ. Anti-obesity effect of crataegus pinnatifida through gut microbiota modulation in high-fat-diet induced obese mice. J Korean Med Rehabil. 2019;29(4):15-27.
6 Park JH, Lim HJ, Lee MJ. The role of gut microbiota in obesity and utilization of fermented herbal extracts. J Korean Med Obes Res. 2009:9(1):1-14.
7 Cao Y, Yao G, Sheng Y, Yang L, Wang Z, Yang Z. Jinqi jiangtang tablet regulates gut microbiota and improve insulin sensitivity in type 2 diabetes mice. J of Diabetes Res. 2019:1872134.   DOI
8 Han L ,Li T, Du M, Chang R, Zhan B, Mao X. Beneficial effects of potentilla discolor bunge water extract on inflammatory cytokines release and gut microbiota in high-fat diet and streptozotocin-induced type 2 diabetic mice. Nutrients. 2019;11(3):670.   DOI
9 Clemente JC, Ursell LK, Parfrey LW, Knight R. The impact of the gut microbiota on human health: an integrative view. Cell. 2012;148:1258-70.   DOI
10 You HJ, Lee SH, Ko GP. Concepts and strategies of the human intestinal microbiome research. The Korean Journal of Public Health. 2015;52(1):11-9.
11 Schwartz S, Friedberg I, Ivanov IV, Davidson LA, Goldsby JS, Dahl DB, Herman D, Wang M, Donovan SM, Chapkin RS. A metagenomic study ofdiet-dependent interaction between gut microbiota and host in infants reveals differences in immune response. Genome Biol. 2012;13:r32.   DOI
12 Gong S, Ye T, Wang M, Wang M, Li Y, Ma L, Yang Y, Wang Y, Zhao X, Liu L, Yang M, Chen H, Qian J. Traditional chinese medicine formula kang shuai lao pian improves obesity, gut gysbiosis, and fecal metabolic disorders in high-fat diet-fed mice. Front Pharmacol. 2020;11:297.   DOI
13 Wei X, Tao J, Xiao S, Jiang S, Shang E, Zhu Z, Qian D, Duan J. Xiexin tang improves the symptom of type 2 diabetic rats by modulation of the gut microbiota. Sci Rep. 2018;8(1):3685.   DOI
14 Gao K, Zhang J, Wang Z, Jia C, Zhang F, Li S, Wang J, Murtaza G, Xie Hua, Zhao H, Wang W, Chen J. Effects of qijian mixture on type 2 diabetes assessed by metabonomics, gut microbiota and network pharmacology. Pharmacol Res. 2018;130:93-109.   DOI
15 Gu W, Yang M, Zhenf LX, Wang X, Dong JC, Li FJ, Yang XX, Li JP, Yu J. Water extract from processed polygonum multiflorum modulate gut microbiota and glucose metabolism on insulin resistant rats. BMC Complement Med Ther. 2020;20(1):107.   DOI
16 Wu R, Zhao D, An R, Wang Z, Li Y, Shi B, Ni Q. Linggui zhugan formula improves glucose and lipid levels and alters gut microbiota in high-fat diet-induced diabetic mice. Front Physiol. 2019;10:918.
17 Zheng J, Chen M, Ye C, Sun X, Jiang N, Wou X, Yang H, Liu H. Buzangtongluo decoction improved hindlimb ischemia by activating angiogenesis and regulating gut microbiota in diabetic mice. J Ethnopharmacol. 2020;248:112330.   DOI
18 Zhang C, Liu J, He X, Sheng Y, Yang C, Li H, Xu J, Xu W, Huang K. Caulis spatholobi ameliorates obesity through activating brown adipose tissue and modulating the composition of gut microbiota. Int J Mol Sci. 2019;20(20):5150.   DOI
19 Chen M, Liao Z, Wang M, Lin L, Zhang S, Li Y, Liu D, Liao Q, Xie Z. Huang-lian-jie-du-decoction ameliorates hyperglycemia and insulin resistant in association with gut microbiota modulation. Front Microbiol. 2018;9:2380.   DOI
20 Chang CJ, Lin CS, Lu CC, Martel J, Ko YF, Ojcius DM, Tseng SF, Wu TR, Chen YY, Young JD, Lai HC. Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota. Nat Commun. 2015;6:7489.   DOI
21 Gu Y. Characteristic of traditional chinese medicine syndrome elements distribution in patients with overweight and simple obesity and effects of jianpi tiao guan yin on white fat browning and gut microbiota in obese mice. Professional degree. Shandong University of Traditional Chinese Medicine. 2018;1-136.
22 Troy EB, Kasper DL. Beneficial effects of bacteroides fragilis polysaccharides on the immune system. Front Biosci (Landmark Ed). 2010;15:25-34   DOI
23 Yilmaz P, Parfrey LW, Yarza P, Gerken J, Pruesse E, Quast C, Schweer T, Peplies J, Ludwig W, Glockner FO. The SILVA and "All-species Living Tree Project (LTP)" taxonomic frameworks. Nucleic Acids Res. 2014(Database issue);D643-8.
24 Cole JR, Wang Q, Fish JA, Chai B, McGarrell DM, Sun Y, Brown CT, Porras-Alfaro A, Kuske CR, Tiedje JM. Ribosomal database project: data and tools for high throughput rRNA analysis. Nucleic Acids Res. 2014;42(Database issue):D633-42.   DOI
25 Federhen, S. The NCBI taxonomy database. Nucleic Acids Res. 2012;40(Database issue):D136-43.   DOI
26 Caporaso JG, Kuczynski J, Stombaugh J, Bittinger K, Bushman FD, Costello EK, Fierer N, Pena AG, Goodrich JK, Gordon JI, Huttley GA, Kelley ST, Knights D, Koenig JE, Ley RE, Lozupone CA, McDonald D, Muegge BD, Pirrung M, Reeder J, Sevinsky JR, Turnbaugh PJ, Walters WA, Widmann J, Yatsunenko T, Zaneveld J, Knight R. QIIME allows analysis of high-throughput community sequencingdata. Nat Methods. 2010;7(5):335-6.   DOI
27 Li J, Cui H, Cai Y, Lin J, Song X, Zhou Z, Xiong W, Zhou H, Bian Y, Wang L. Tong-xie-yao-fang regulates 5-HT level in diarrhea predominant irritable bowel syndrome through gut microbiota modulation. Front Pharmacol. 2018;9:1110.   DOI
28 Huang X, Chen W, Yan C, Yang R, Chen Q, Xu H, Huang Y. Gypenosides improve the intestinal microbiota of non-alcoholic fatty liver in mice and alleviate its progression. Biomed Pharmacother. 2019;118:109258.   DOI
29 Jia N, Lin X, Ma S, Ge S, Mu S, Yang C, Shi S, Gao L, Xu J, Bo T, Zhao J. Amelioration of hepatic steatosis is associated with modulation of gut microbiota and suppression of hepatic miR-34a in gynostemma pentaphylla (thunb.) makino treated mice. J Nutr Metab (Lond). 2018;15:86.   DOI
30 Chen Y, Xiao S, Gong Z, Zhu X, Yang Q, Li Y, Gao S, Dong Y, Shi Z, Wang Y, Weng X, Li Q, Cai W, Qiang W. Wuji wan formula ameliorates diarrhea and disordered colonic motility in post-inflammation irritable bowel syndrome rats by modulating the gut microbiota. Front Microbiol. 2017;8:2307.   DOI
31 Zhang Z, Cao H, Shen P, Liu J, Cao Y, Zhang N. Ping weisan alleviates chronic colitis in mice by regulating intestinal microbiota composition. J Ethnopharmacol. 2020;255:112715.   DOI
32 Wu ZC, Zhao ZL, Deng JP, Huang JT, Wang YF, Wang ZP. Sanhuang shu'ai decoction alleviates DSS-induced ulcerative colitis via regulation of gut microbiota, inflammatory mediators and cytokines. Biomed Pharmacother. 2020;125:109934.   DOI
33 Zhang H, Hui D, Li Y, Xiong G, Fu X. Canmei formula reduces colitis-associated colorectal carcinogenesis in mice by modulating the composition of gut microbiota. Front Oncol. 2019;9:1149.   DOI
34 Shi K, Qu L, Xie X, Tu J, Liu X, Zhou Z, Cao G, Li S, Liu Y. Deep-fried atractylodis rhizoma protects against spleen deficiency-induced diarrhea through regulating intestinal inflammatory response and gut microbiota. Int J Mol Sci. 2019;21(1):124.   DOI
35 Shenghua P, Ziqin Z, Shuyu T, Huixia Z, Xianglu R, Jiao G. An integrated fecal microbiome and metabolome in the aged mice reveal anti-aging effects from the intestines and biochemical mechanism of FuFang zhenshu TiaoZhi (FTZ). Biomed Pharmacother. 2020;121:109421.   DOI
36 Zhang F, Zhai M, Wu Q, Jia X, Wang Y, Wang N. Protective effect of Tong-qiao-huo-xue decoction on inflammatory injury caused by intestinal microbial disorders in stroke rats. Biol Pharm Bull. 2020;43(5):788-800.   DOI
37 Zhang WJ, Su WW, Li PB, Rao HY, Lin QW, Weng X, Chen TB, Yan WH, Yao HL. Naoxintong capsule inhibits the development of cardiovascular pathological changes in bama minipig through improving gut microbiota. Front Pharmacol. 2019;10:1128.   DOI
38 Qu W. Impact of traditional chinese medicine treatment on chronic unpredictable mild stress-induced depression-like behaviors and fecal microbiota. Master degree. South China University of Technology Guangzhou, China. 2019:1-74.
39 The NIH HMP working group, Peterson J, Garges S, Giovanni M, McInnes P, Wang L, A.Schloss J, Bonazzi V, E.McEwen J, A.Wetterstrand K, Deal C, C.Baker C, Francesco VD, Howcrof TK, W.Karp R, Lunsford RD, R.Wellington C, Belachew T, Wright M, David H, Mills M, Salomon R, Mullins C, Akolkar B, Begg L, Davis C, Grandison L, Humble M, Khalsa J, Little RA, Peavy H, Pontzer C, Portnoy M, H. Sayre M, Starke-Reed P, Zakhari S, Read J, Watson B, Guyer M. The NIH human microbiome project. Genome Res. 2009. 19(12): p.2317-23.   DOI
40 Ryu DY, Kim KB. Current trends and future directions of gut microbiota and their-derived metabolite study in the pediatric perspective of korean medicine. J Pediatr Korean Med. 2019;33(1):34-45.   DOI
41 Kostic AD, Howitt MR, Garrett WS. Exploring host-microbiota interactions in animal models and humans. Genes Dev. 2013; 27:701-18.   DOI
42 Korean association for laboratory animal science commission of accreditation committee. Animal experiment guide. OKVET. 2015;9-46.
43 Hebbard L, George J. Animal models of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol. 2010;8:35-44.   DOI
44 Jang BI. Animal modles of inflammatory bowel disease. Intest Tes. 2008;6(1)8-18.
45 Compilation Committee of National Universitiy of Korean Medicine. Herbology. Seoul: Yeonglimsa. 2017;218-21,577-81.
46 Kim JM, Jung HA, Choi JS, Lee NG. Identification of anti-inflammatory target genes of rhizoma coptidis extract in lipopolysaccharide-stimulated RAW264.7 murine macrophage-like cells. J Ethnopharmacol. 2010;130(2):354-62.   DOI
47 An X, Bao Qi, Di S, Zhao Y, Zhao Y, Zhao S, Zhang H, Lian F, Tong X. The interaction between the gut microbiota and herbal medicines. Biomed Pharmacother. 2019;118:109252.   DOI
48 Kim GM. Ulmus macrocarpa Hance extract has effects on intestinal microflora of healthy persons. Master degree. Department of Medical Science School of Medicine Pusan National University. 2018;8-31.
49 Kim OS, Cho YJ, Lee KH, Yoon SH, Kim MC, Na HS, Park SC, Jeon YS, Lee JH, Yi HN, Won SH, Chun SC. Introducing EzTaxon-e: a prokaryotic 16S rRNA gene sequence database with phylotypes that represent uncultured species. Int J Syst Evol Microbiol. 2012;62(Pt 3):716-21.   DOI