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http://dx.doi.org/10.7778/jpkm.2019.33.3.082

A Review of Recent Clinical Researches in Chinese Medical Journal for Efficacy and Safety of Pediatric Herbal Medicine Inhalation Therapy  

Park, Sul Gi (Department of Korean Pediatrics, Graduate School, Kyung Hee University)
Park, So Hyun (Department of Korean Pediatrics, Graduate School, Kyung Hee University)
Shin, Dong Gil (Incheon Lotte Hamsoa Korean Medical Clinic)
Lee, Sun Haeng (Department of Korean Pediatrics, Graduate School, Kyung Hee University)
Lee, Jin Yong (Department of Korean Pediatrics, Graduate School, Kyung Hee University)
Publication Information
The Journal of Pediatrics of Korean Medicine / v.33, no.3, 2019 , pp. 82-102 More about this Journal
Abstract
Objectives The purpose of this study is to investigate clinical studies on the efficacy and safety of herbal medicine inhalation therapy in children by analyzing recent randomized controlled trials conducted in China. Methods We searched the clinical studies from the China Academic Journal (CAJ) in China National Knowledge Infrastructure (CNKI) using a by key word '霧化吸入' and specific criteria from 1st January 2010 to 2nd July 2019. Data regarding years of publication, demographic information, target diseases or symptoms, treatment methods, outcome measure, results and adverse events are collected for this study. Results Total of 44 randomized controlled trials were selected and analyzed. Respiratory diseases and symptoms (84.1%) were the most frequent target diseases that herbal medicine inhalation therapy was used. Acute stomatitis was another disease state that the therapy was used. In most of the studies, the herbal medicine inhalation in children showed significant efficacies. The most commonly used herbal medicines were Ephedrae Herba (麻黃), Lonicera Flos (金銀花), Armeniacae Semen (杏仁), Glycyrrhizae Radix et Rhizoma (甘草), Scutellaria Radix (黃芩), Forsythia Fructus (連翹) etc. Hardly any adverse effects were reported from the trials selected. Conclusions Based on the results of the clinical studies from China, herbal medicine inhalation therapy in children can be an effective and safe option for treatment and symptom improvement.
Keywords
Herbal medicine inhalation therapy; Children; Chinese medical journal; Review;
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1 Zhuang XG, Zhang ZB. Clinical efficacy analysis of traditional chinese medicine oxygen atomization inhalation treatment of children respiratory diseases. Clin J Chin Med. 2018;10(3):23-5.
2 Lee BW, Kim EH, Kim KW, Park HK. A Study on fumigation therapy and aroma therapy of wai-tai-mi-yao. J Korean Med Classics. 2005;18(3):116-25.
3 Hwang CH, Kim KS, Um JT, Hwang SY, Jo HK, Kim BS. Study on Effects of Incense Smokes Composed with Oriental Medical Herbs on HRV and Stress Relaxation. J Physiol & Pathol Korean Med. 2012;26(4):566-71.
4 Um JT, Kim KS, Kim BS. The Effects of Incense Smokes of 'Cheung-Woon' on HRV. J Orient Neuropsychiatry, 2012;23(3):89-97.   DOI
5 Shin JI. A Clinical Report about the Effect of Fumigating Therapy on a Acute Stroke Patient. J Korean Oriental Med. 2001;22(4):158-63.
6 Song YA. Literature study on korean traditional sromaherapy-centered around research on utility of korean incense plant-. Doctor's thesis (Department of Food & Nutrition). Seoul: Sungshin University; 2016.
7 Miao XQ, Zhou J, Li J, Liao YH, Zheng Y. Chinese medicine in inhalation therapy: a review of clinical application and formulation development. Curr Pharm Des. 2015;21:3917-31.   DOI
8 Stephen WS, Charles GT. The history of therapeutic aerosols: a chronological review. J Aerosol Med Pulm Drug Deliv. 2017;30(1):20-41.   DOI
9 Yoon JH, Lee GS, Jun SH, Ju YS. A literature review on medicinal actions and indications of Ephedrae herba from Korean medicine's viewpoints. Korean Herb Med Inform. 2017;5(2):23-36.
10 Kim IR, Kim HC, Kuk YB, Park SJ, Park YG, Park JH, Seo BI, Seo YB, Song HJ, Shin MK, Lee YJ, Lee YC, Lee JH, Lim GH, Jo SI, Jung JG, Joo YS, Choi HY. Bonchohak. Seoul: Young Lim Sa Publishing Co. 2010:194.
11 Kapadia CR, Nebesio TD, Myers SE, Willi S, Miller BS, Allen DB, Jacobson-Dickman E. Endocrine effects of inhaled corticosteroids in children. JAMA Pediatr. 2016;170(2):163-70.   DOI
12 Leonard PR, Craig AW. Ototoxicity: therapeutic opportunities. Drug Discovery Today. 2005;10(19):1313-21   DOI
13 Lee ES, Han JM, Kim MH, Namgung U, Yeo Y, Park YC. Effects of inhalable microparticles of Socheongryongtang on chronic obstructive pulmonary disease in a mouse model. J Korean Med. 2013;34(3):54-68.   DOI
14 Koo JS, Baek JH. A clinical study on the effect of Tongkyu-tang distillate on pediatric allergic rhinitis. J Pediatr Korean Med. 2003;17(2):103-14.
15 Yang SY, Oh JS, Park YC, Oh YS, Lee YK. Research trends of inhalation drug for asthma in complementary and alternative medicine. J Haehwa Med. 2009;18(1):1-8.
16 Kim JE, Hong CH. Survey on effect and satisfaction of korean medicine distillate nasal spray of patient with chronic rhinitis. J Korean Med Ophthalmol Otolaryngol Dermatol. 2012;25(3):56-64.   DOI
17 Bang MR, Kim JH, Min SY. A literature study of topical application of chinese herbal medicine for allergic rhinitis. J Pediatr Korean Med. 2016;30(3):52-60.   DOI
18 Yoon DH. Review of herbal medicine inhalation therapy on asthma in chinese medical journal. J Jeahan Orient Med Acad. 2004;29(1):34-40.
19 Cui YX. Clinical observation on treatment of 55 cases of upper respiratory tract infection in children with Tanreqing injection. Chin J Mod Drug Appl. 2010;4(4):169-70.
20 Choi HJ, Bang NY, Song BW, Kim NJ, Rhyu BH. Survey on the preference for the dosage forms of oriental herbal medicine. Kyunghee Medicine. 2004;20(1):46-57.
21 Park KH. Clinical application of drug delivery system. J Korean Soc Hosp Pharm. 1992;9(3):194-208.
22 Tayap ZR, Hochhaus G. Pharmacokinetic/pharmacodynamic evaluation of inhalation drugs: application to targeted pulmonary delivery systems. Expert Opin Drug Deliv. 2005;2(3):519-32.   DOI
23 Li W, Li ZY. Therapeutic effect of Shuanghuanglian inhalation in the treatment of 40 cases of herpetic angina in children. J Pedia Tradit Chin Med. 2010;6(5):26-7.
24 Li WD. Analysis of the effect of decoction and inhalation of traditional Chinese medicine on children with asthmatic pneumonia. Chin J Mod Drug Appl. 2010;4(3):141-2.
25 Song HM. Therapeutic effect of traditional Chinese medicine inhalation on children with intractable cough. Chin J Misdiagn. 2010;10(19):4634.
26 Chen LY. An effective analysis of treating asthmatic pneumonia in children by inhalation of TCM decoction atomization. Clin J Chin Med. 2011;3(10):49-50.
27 Wang W. Ultrasonic nebulization of Feining decoction in the treatment of 66 children with pneumonia. Hebei J TCM. 2010;32(8):1157.
28 You QP. Observation on effect of Qingyan-detoxification mixture nebulization inhalation as assistant to treat children with acute tonsillitis. Chin Gen Nurs. 2010;8(12A):3118-9.
29 Kim KB, Kim DG, Kim YH, Kim JH, Min SY, Park EJ, Baek JH, Sung HK, Yu SA, Lee SY, Lee JY, Chang GT, Jeong MJ, Chai JW, Cheon JH, Han YJ, Han JK. Hanbangsoacheongsonyeonuihak (sang). Seoul: Ui Sung Dang Publishing Co. 2015:184.
30 Zhao YP. Therapeutic effect of Zhichuanling injection on 136 children with asthmatic bronchitis. Chin J Coal Ind Med. 2010;13(1):60-1.
31 Li BY. Inhalation of Qingkailing injection in the treatment of 45 cases of bronchiolitis. J Emerg Tradit Chin Med. 2011;20(9):1496.
32 Nie WX, Yang LH, Yi YJ. Clinical study on 127 cases of infantile acute bronchitis treated by ultrasound atomization inhalation of Reduning injection. Guide China Med. 2011;9(35):185-7.
33 Wang YY. Effect of aerosol inhalation of Astragalus injection on cellular immune function in children with repeated respiratory infection. Chin J Misdiagn. 2011;11(18):4325-6.
34 Weng QY, Zhao JY, Bian XQ, Wu JN, Wang KM. Clinical observation on 90 cases of infantile bronchial asthma in acute attack treated with integrated traditional chinese and western medicine. Chin Med Mod Distance Edu China. 2011;9(13):52.
35 Xia ZT. Comparison of different routes of administration of Tanreqing injection in the treatment of herpes simplex angina. J Emerg Tradit Chin Med. 2011;20(10):1704.
36 Chen HY. Clinical observation of effects of Kangganliyan spray aerosol on children with hand-foot-mouth disease. Chin J Med Guide. 2013;15(12)2024-5.
37 Xing LH. Treatment of 60 cases of herpetic stomatitis in children with aerosolized inhalation of Renaning injection. Chin Med Mod Distance Edu China. 2011;9(20):36-7.
38 Hu QW, Wen MS, Gan XX, Wu CX. Clinical observation of treating pneumonia in children by TCM dialectical aerosol inhalation. Clin J Chin Med. 2012;4(9):59-60.
39 Liu HJ, Song X. Clinical observation of Dongxia Liyan mixture Aerosol inhalation in the treatment of chronic pharyngitis in children. Asia Pac Tradit Med. 2012;8(2):69.
40 Zhang XY, Huang J. Clinical observation of treatment of children with allergic rhinitis with Xinju atomization. Jilin Med J. 2012;33(13);2759-60.
41 Hu YS, Zou LY. Therapeutic effect of chrysanthemum nebulization on 89 children with acute upper respiratory tract infection. J Qiqihar Univ Med. 2013;34(8):1166-7.
42 Li GQ, Li ZM, Yu XC, Liu JJ, Zhang JR. Clinical observation on 200 cases of hand, foot and mouth disease of Lung-heat type treated by aerosol inhalation of Qingre Jiedu Formula. Hebei J TCM. 2013;35(7):989-90.
43 Wang YF, Zhong T, Su Y, He P. Observation on therapeutic effect of aerosol inhalation of Xiaolingdan mixture on 158 cases of acute tonsillitis in children. Hunan J Tradit Chin Med. 2013;29(12):63-4.
44 Wei CG. 45 cases of infantile bronchiolitis treated by chinese medicine atomization. Chin Med Mod Distance Edu China. 2013;11(23):51.
45 Wu LL. Treatment of 88 children with repeated respiratory tract infection by Tanreqing atomization inhalation. Chin Foreign Med Res. 2013;11(3):109.
46 Yan W. Clinical observation of Tanreqing injection inhalation in the treatment of children with herpangina. Asia Pac Tradit Med. 2014;10(6):114.
47 Cai QE. Therapeutic effect of traditional Chinese medicine granules inhalation on children with exogenous cough. Chin J Clin Ration Drug Use. 2014;7(7):78-9.
48 Gao JM. Children's Allergic Rhinitis Treated with Ultrasonic Nebulization of Jiegen Yuanshen Decotion and Yupingfeng Powder. Liaoning J Tradit Chin Med. 2014;41(11):2417-8.
49 Kong XH. Therapeutic effect of Tanreqing atomization on asthmatic bronchitis in children. China Prac Med. 2014;9(17):165.
50 Sun TF, Hu H, Liu YK, Zhang QY. Clinical observation of ultrasound atomization inhalation of traditional chinese medicine in the treatment of pediatric pneumonia of wind-heat closing lung type. Mod J Integr Tradit Chin Western Med. 2014;23(8):824-6.   DOI
51 Zhan HY. Efficacy of Chinese Medicine Granules Atomizing Inhalation in the Treatment of Children with Exogenous Cough. China Foreign Med Treat. 2014;33:33-7.
52 Chen YX. Observation on the therapeutic effect of Lingnan herbs on allergic cough. Shenzhen J Integr Tradit Western Med. 2015;25(16):73-4.
53 Zhang CM, Qian X, Zhang XY. Therapeutic observation on 50 cases of acute suppurative tonsillitis treated by chinese medicine atomization inhalation. Zhejiang J Tradit Chin Med. 2015;50(4):262.
54 Zhao AM. Effect of chinese and western medicine on the treatment of chronic pharyngitis in children. Cardiovasc Dis J Integr Tradit Chin Western Med. 2016;4(35):167.
55 Yu XY. Curative effect observation on 60 cases of acute suppurative tonsillitis in children treated by aerosol inhalation of Kangfuxin liquid. Zhejiang J Tradit Chin Med. 2017;52(3):203.
56 Li XH, Zhu CG, Liu HF. Observation of combined TCM inhalation therapeutic effect on children with cold cough . World Latest Med Info. 2018;18(42):154-5.
57 Yuan J. Liyanyin nebulized inhalation for the treatment of acute pharyngitis in children. J Clin Med. 2017;4(27):5225-6.
58 Zhang TW. Clinical observation on curative effects of aerobic inhalation of Redu'ning on acute upper respiratory tract infection in children. Clin J Chin Med.2017;9(34):61-2.
59 Zhang W, Xie H. Clinical study on inhalation of Tanreqing injection in treating children with bronchial asthma. J Emerg Tradit Chin Med. 2017;26(9):1688-9.
60 Hu SZ, Shen HX, Tang Q. Observation on curative effect of aerosol inhalation of traditional Chinese medicine on hand foot mouth disease. Chin J Mod Drug Appl. 2018;12(17):195-7.
61 Ning HY. Clinical observation of chinese medicine atomization in treating children with bronchitis. China's naturopathy. 2018;26(4):35-6.
62 Tan XY, Feng MY. Effect of inhalation of wild chrysanthemum injection on acute suppurative tonsillitis in children. Inner Mongol J Tradit Chin Med. 2018;37(2):82-3.
63 Wang ZH. Clinical effect of integrated traditional chinese and western medicine on cough variant asthma in children. Chin Gen Pract. 2018;21(S2):192-3.
64 Yu Y, Huang W, Ye Q, Zhang H, Huang QY, Huang SY, Guo Y. Therapeutic effect of traditional chinese medicine inhalation on chronic pharyngitis in children. Liaoning J Tradit Chin Med. 2018;45(3):532-4.
65 Yuan HZ. Clinical Observation on 70 cases of chronic rhinitis in children treated with Xanthium powder by nasal atomization inhalation. World Latest Med Info. 2018;18(23):144-8.