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http://dx.doi.org/10.7778/jpkm.2017.31.3.014

Effect of Skin Fat Lipid Barrier Formation on Hataedock with Coptis Japonica & Glycyrrhiza Uralensis  

Ahn, Sang Hyun (Department of Anatomy, College of Korean Medicine, Semyung University)
Kim, Ki Bong (School of Korean Medicine, Pusan National University)
Publication Information
The Journal of Pediatrics of Korean Medicine / v.31, no.3, 2017 , pp. 14-23 More about this Journal
Abstract
Objectives This study is conducted to evaluate skin fat barrier formation of Hataedock using the Coptis japonica & Glycyrrhiza uralensis extract. Methods The 3-week-old NC/Nga mice were divided into 3 groups: control group (Ctrl), Hataedock-treated group that uses the Coptis japonica & Glycyrrhiza uralensis (CGT) extract, and Hataedock-treated group that uses Bifidobacterium (BBT). After 2 weeks, changes in immunohistochemicals, and skin-lipid-barrier regulators were observed for the effects of Hataedock. Results In CGT group, loricrin-positive reaction has been increased by 231%, along with involucrin-positive reaction by 90%, filaggrin-positive reaction by 143%, and ASM-positive reaction by 341% in the stratum corneum. Conclusions Hataedock, using the extract of Coptis japonica & Glycyrrhiza uralensis, increased the expression of proteins promoting keratinocyte differentiation. This leads into conclusion that Hataedock may increase the keratinocyte formation and function which promotes skin barrier formation.
Keywords
Hataedock; Filaggrin; Loricrin; Involucrin; Skin;
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