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http://dx.doi.org/10.7778/jpkm.2012.26.2.013

Effects of Nardostachys Jatamansi on Atopic Dermatitis-like Skin Lesions  

Min, Deul-Le (Department of Pediatrics, College of Oriental Medicine, Wonkwang University)
Park, Eun-Jung (Department of Pediatrics, College of Oriental Medicine, Wonkwang University)
Publication Information
The Journal of Pediatrics of Korean Medicine / v.26, no.2, 2012 , pp. 13-24 More about this Journal
Abstract
Objectives NJ is being used to treat inflammatory diseases in Korea. In this study, we attempted to evaluate the effects of NJ on atopic dermatitis (AD)-like lesions and mast cell-mediated allergy inflammation in vivo and in vitro. Methods and Results We investigated to ascertain the pharmacological effects of NJ on 2,4-dinitrofluorobenzene (DNFB)-induced allergic reactions under in vivo conditions. Additionally, to find possible explanations for the anti-inflammatory mechanisms of NJ, we evaluated the regulatory effects of NJ on the level of inflammatory mediators in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells (HMC-1). Conclusions NJ inhibited the production of the inflammatory cytokines (IgE, IL-6, IL-8 and TNF-${\alpha}$) significantly in vivo and in vitro.
Keywords
Nardostachys Jatamansi; Atopic dermatitis; Inflammatory cytokine; Human mast cells-1;
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