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http://dx.doi.org/10.23005/ksmls.2022.7.2.74

Fluorescent and Luminescent Proteins Derived from Marine Organisms: Functions and Applications  

Sehyeok, Im (Research Unit of Cryogenic Novel Material, Korea Polar Research Institute)
Jisub, Hwang (Research Unit of Cryogenic Novel Material, Korea Polar Research Institute)
Hackwon, Do (Research Unit of Cryogenic Novel Material, Korea Polar Research Institute)
Bo-Mi, Kim (Research Unit of Cryogenic Novel Material, Korea Polar Research Institute)
Sung Gu, Lee (Research Unit of Cryogenic Novel Material, Korea Polar Research Institute)
Jun Hyuck, Lee (Research Unit of Cryogenic Novel Material, Korea Polar Research Institute)
Publication Information
Journal of Marine Life Science / v.7, no.2, 2022 , pp. 74-85 More about this Journal
Abstract
Organisms constituting a large proportion of marine ecosystems, ranging from bacteria to fish, exhibit fluorescence and bioluminescence. A variety of marine organisms utilize these biochemically generated light sources for feeding, reproduction, communication, and defense. Since the discovery of green fluorescent protein and the luciferin-luciferase system more than a century ago, numerous studies have been conducted to characterize their function and regulatory mechanism. The unique properties of fluorescent and bioluminescent proteins offer great potential for their use in a broad range of applications. This short review briefly describes the functions and characteristics of fluorescent and bioluminescent proteins, in addition to summarizing the recent status of their applications.
Keywords
Fluorescence; Luminescence; Marine; Proteins;
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1 Titushin MS, Markova SV, Frank LA, Malikova NP, Stepanyuk GA, Lee J, Vysotski ES. 2008. Coelenterazine-binding protein of Renilla muelleri: cDNA cloning, overexpression, and characterization as a substrate of luciferase. Photochem Photobiol Sci 7: 189-196.   DOI
2 Tsutsui K, Shimada E, Ogawa T, Tsuruwaka Y. 2016. A novel fluorescent protein from the deep-sea anemone Cribrinopsis japonica (Anthozoa: Actiniaria). Sci Rep 6: 23493.
3 Vecchio D, Dai T, Huang L, Fantetti L, Roncucci G, Hamblin MR. 2013. Antimicrobial photodynamic therapy with RLP068 kills methicillin-resistant Staphylococcus aureus and improves wound healing in a mouse model of infected skin abrasion PDT with RLP068/Cl in infected mouse skin abrasion. J Biophotonics 6: 733-742.   DOI
4 Verhaegent M, Christopoulos TK. 2002. Recombinant Gaussia luciferase. Overexpression, purification, and analytical application of a bioluminescent reporter for DNA hybridization. Anal Chem 74: 4378-4385.   DOI
5 Vysotski ES, Lee J. 2004. Ca2+-regulated photoproteins: structural insight into the bioluminescence mechanism. Acc Chem Res 37: 405-415.   DOI
6 Wang B, Barahona M, Buck M. 2013. A modular cell-based biosensor using engineered genetic logic circuits to detect and integrate multiple environmental signals. Biosens Bioelectron 40: 368-376.   DOI
7 Wang Y, Wang G, O'Kane DJ, Szalay AA. 1998. The RenillaLuciferase-Modified GFP Fusion Protein is Functional in Transformed Cells. BioHydrogen 493-499.
8 Warrant EJ, Locket NA. 2004. Vision in the deep sea. Biol Rev Camb Philos Soc 79: 671-712.   DOI
9 Wehr MC, Rossner MJ. 2016. Split protein biosensor assays in molecular pharmacological studies. Drug Discov Today 21: 415-429.   DOI
10 Hassan SH, Van Ginkel SW, Hussein MA, Abskharon R, Oh SE. 2016. Toxicity assessment using different bioassays and microbial biosensors. Environ Int 92-93: 106-118.   DOI
11 Hastings JW. 1983. Biological diversity, chemical mechanisms, and the evolutionary origins of bioluminescent systems. J Mol Evol 19: 309-321.   DOI
12 Heinermann PH. 1984. Yellow intraocular filters in fishes. Exp Biol 43: 127-147.
13 Henry JP, Michelson AM. 1978. Bioluminescence: physiological control and regulation at the molecular level. Photochem Photobiol 28: 293-310.   DOI
14 Hoare BL, Bruell S, Sethi A, Gooley PR, Lew MJ, Hossain MA, et al. 2019. Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis. iScience 11: 93-113.   DOI
15 Hunt ME, Scherrer MP, Ferrari FD, Matz MV. 2010. Very bright green fluorescent proteins from the Pontellid copepod Pontella mimocerami. PLoS One 5: e11517.
16 Iannotti FA, Pagano E, Guardiola O, Adinolfi S, Saccone V, Consalvi S, et al. 2018. Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy. Nat Commun 9: 3950.
17 Inouye S, Watanabe K, Nakamura H, Shimomura O. 2000. Secretional luciferase of the luminous shrimp Oplophorus gracilirostris: cDNA cloning of a novel imidazopyrazinone luciferase. FEBS Lett 481: 19-25.   DOI
18 Johnson CH, Inoue S, Flint A, Hastings JW. 1985. Compartmentalization of algal bioluminescence: autofluorescence of bioluminescent particles in the dinoflagellate Gonyaulax as studied with image-intensified video microscopy and flow cytometry. J Cell Biol 100: 1435-1446.   DOI
19 White SR, Christopoulos TK. 1999. Signal amplification system for DNA hybridization assays based on in vitro expression of a DNA label encoding apoaequorin. Nucleic Acids Res 27: e25.
20 Whelan S, Goldman N. 2001. A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach. Molecular Biology and Evolution 18: 691-699.   DOI
21 Widder EA. 1999. Bioluminescence. Archer SN, Djamgoz MBA, Loew ER, Partridge JC, Vallerga S (Eds.), Adaptive Mechanisms in the Ecology of Vision. Springer, Dordrecht, pp 555-581.
22 Widder EA. 2002. Bioluminescence and the Pelagic Visual Environment. Mar Freshwat Behav Physiol 35: 1-26.   DOI
23 Widder EA. 2010. Bioluminescence in the ocean: origins of biological, chemical, and ecological diversity. Science 328: 704-708.   DOI
24 Wood KV, Lam YA, Seliger HH, McElroy WD. 1989. Complementary DNA coding click beetle luciferases can elicit bioluminescence of different colors. Science 244: 700-702.   DOI
25 Xiao L, Yang C, Nelson CO, Holloway BP, Udhayakumar V, Lal AA. 1996. Quantitation of RT-PCR amplified cytokine mRNA by aequorin-based bioluminescence immunoassay. J Immunol Methods 199: 139-147.   DOI
26 Yang Y, Du L, Liu C, Wang L, Ma C, Tang J, et al. 2014. Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus. Proc Natl Acad Sci U S A 111: 12516-12521.   DOI
27 Yue JX, Holland ND, Holland LZ, Deheyn DD. 2016. The evolution of genes encoding for green fluorescent proteins: insights from cephalochordates (amphioxus). Sci Rep 6: 28350.
28 Zatta PF. 1996. A new bioluminescent assay for studies of protein G and protein A binding to IgG and IgM. J Biochem Biophys Methods 32: 7-13.   DOI
29 Kadurugamuwa JL, Sin LV, Yu J, Francis KP, Kimura R, Purchio T, Contag PR. 2003. Rapid direct method for monitoring antibiotics in a mouse model of bacterial biofilm infection. Antimicrob Agents Chemother 47: 3130-3137.   DOI
30 Jonkers TJH, Steenhuis M, Schalkwijk L, Luirink J, Bald D, Houtman CJ, et al. 2020. Development of a high-throughput bioassay for screening of antibiotics in aquatic environmental samples. Sci Total Environ 729: 139028.
31 Karlsson EA, Meliopoulos VA, Savage C, Livingston B, Mehle A, Schultz-Cherry S. 2015. Visualizing real-time influenza virus infection, transmission and protection in ferrets. Nat Commun 6: 6378.
32 Kaskova ZM, Tsarkova AS, Yampolsky IV. 2016. 1001 lights: luciferins, luciferases, their mechanisms of action and applications in chemical analysis, biology and medicine. Chem Soc Rev 45: 6048-6077.   DOI
33 Kumar S, Stecher G, Li M, Knyaz C, Tamura K. 2018. MEGA X: Molecular Evolutionary Genetics Analysis across computing platforms. Molecular Biology and Evolution 35:1547-1549.   DOI
34 Lan J, Ge J, Yu J, Shan S, Zhou H, Fan S, et al. 2020. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature 581: 215-220.   DOI
35 Shagin DA, Barsova EV, Yanushevich YG, Fradkov AF, Lukyanov KA, Labas YA, et al. 2004. GFP-like proteins as ubiquitous metazoan superfamily: evolution of functional features and structural complexity. Mol Biol Evol 21: 841-850.   DOI
36 Zeamari S, Rumping G, Floot B, Lyons S, Stewart FA. 2004. In vivo bioluminescence imaging of locally disseminated colon carcinoma in rats. Br J Cancer 90: 1259-1264.   DOI
37 Zhang N, Fu Z, Linke S, Chicher J, Gorman JJ, Visk D, et al. 2010. The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab 11: 364-378.   DOI
38 Zhao G, Du L, Ma C, Li Y, Li L, Poon VK, et al. 2013. A safe and convenient pseudovirus-based inhibition assay to detect neutralizing antibodies and screen for viral entry inhibitors against the novel human coronavirus MERS-CoV. Virol J 10: 266.  
39 Lee JH, Youn CH, Kim BC, Gu MB. 2007. An oxidative stressspecific bacterial cell array chip for toxicity analysis. Biosens Bioelectron 22: 2223-2229.
40 Lee S, Zhang C, Liu X. 2015. Role of glucose metabolism and ATP in maintaining PINK1 levels during Parkin-mediated mitochondrial damage responses. J Biol Chem 290: 904-917.   DOI
41 Liu L, Wilson T, Hastings JW. 2004. Molecular evolution of dinoflagellate luciferases, enzymes with three catalytic domains in a single polypeptide. Proc Natl Acad Sci U S A 101: 16555-16560.   DOI
42 Lloyd JE. 1983. Bioluminescence and communication in insects. Annu Rev Entomol 28: 131-160.   DOI
43 Loening AM, Fenn TD, Wu AM, Gambhir SS. 2006. Consensus guided mutagenesis of Renilla luciferase yields enhanced stability and light output. Protein Eng Des Sel 19: 391-400.   DOI
44 Markova SV, Larionova MD, Vysotski ES. 2019. Shining Light on the Secreted Luciferases of Marine Copepods: Current Knowledge and Applications. Photochem Photobiol 95: 705-721.   DOI
45 Lorenz WW, McCann RO, Longiaru M, Cormier MJ. 1991. Isolation and expression of a cDNA encoding Renilla reniformis luciferase. Proc Natl Acad Sci U S A 88: 4438-4442.   DOI
46 Lundin A. 2014. Optimization of the firefly luciferase reaction for analytical purposes. Adv Biochem Eng Biotechnol 145: 31-62.
47 Macel ML, Ristoratore F, Locascio A, Spagnuolo A, Sordino P, D'Aniello S. 2020. Sea as a color palette: the ecology and evolution of fluorescence. Zoological Lett 6: 9.
48 Markova SV, Golz S, Frank LA, Kalthof B, Vysotski ES. 2004. Cloning and expression of cDNA for a luciferase from the marine copepod Metridia longa. A novel secreted bioluminescent reporter enzyme. J Biol Chem 279: 3212-3217.   DOI
49 Martini S, Haddock SH. 2017. Quantification of bioluminescence from the surface to the deep sea demonstrates its predominance as an ecological trait. Sci Rep 7: 45750.
50 Matz MV, Labas YA, Ugalde J. 2006. Evolution of function and color in GFP-like proteins. Methods Biochem Anal 47: 139-161.   DOI
51 Meyer-Rochow VB. 2007. Glowworms: a review of Arachnocampa spp. and kin. Luminescence 22: 251-265.   DOI
52 Michiels NK, Anthes N, Hart NS, Herler J, Meixner AJ, Schleifenbaum F, et al. 2008. Red fluorescence in reef fish: a novel signalling mechanism? BMC Ecol 8: 16.
53 Mocz G. 2007. Fluorescent proteins and their use in marine biosciences, biotechnology, and proteomics. Mar Biotechnol (NY) 9: 305-328.   DOI
54 Ohmiya Y, Hirano T. 1996. Shining the light: the mechanism of the bioluminescence reaction of calcium-binding photoproteins. Chem Biol 3: 337-347.   DOI
55 Morciano G, Sarti AC, Marchi S, Missiroli S, Falzoni S, Raffaghello L, et al. 2017. Use of luciferase probes to measure ATP in living cells and animals. Nat Protoc 12: 1542-1562.   DOI
56 Nakamura H, Musicki B, Kishi Y, Shimomura O. 1988. Structure of the light emitter in krill (Euphausia pacifica) bioluminescence. J Am Chem Soc 110: 2683-2685.   DOI
57 Niu J, Shen L, Huang B, Ye F, Zhao L, Wang H, et al. 2020. Noninvasive bioluminescence imaging of HCoV-OC43 infection and therapy in the central nervous system of live mice. Antiviral Res 173: 104646.
58 Ong TT, Ang Z, Verma R, Koean R, Tam JKC, Ding JL. 2020. pHLuc, a Ratiometric Luminescent Reporter for in vivo Monitoring of Tumor Acidosis. Front Bioeng Biotechnol 8: 412.
59 Palikaras K, Tavernarakis N. 2016. Intracellular Assessment of ATP Levels in Caenorhabditis elegans. Bio Protoc 6.
60 Pelentir GF, Bevilaqua VR, Viviani VR. 2019. A highly efficient, thermostable and cadmium selective firefly luciferase suitable for ratiometric metal and pH biosensing and for sensitive ATP assays. Photochem Photobiol Sci 18: 2061-2070.   DOI
61 Pfleger KD, Eidne KA. 2006. Illuminating insights into proteinprotein interactions using bioluminescence resonance energy transfer (BRET). Nat Methods 3: 165-174.   DOI
62 Phillips AT, Rico AB, Stauft CB, Hammond SL, Aboellail TA, Tjalkens RB, Olson KE. 2016. Entry Sites of Venezuelan and Western Equine Encephalitis Viruses in the Mouse Central Nervous System following Peripheral Infection. J Virol 90: 5785-5796.   DOI
63 Poisson J. 2010. [Raphael Dubois, from pharmacy to bioluminescence]. Rev Hist Pharm (Paris) 58: 51-56.    DOI
64 Rincon E, Cejalvo T, Kanojia D, Alfranca A, Rodriguez-Milla MA, Gil Hoyos RA, et al. 2017. Mesenchymal stem cell carriers enhance antitumor efficacy of oncolytic adenoviruses in an immunocompetent mouse model. Oncotarget 8: 45415-45431.   DOI
65 Pugh PR, Haddock SH. 2010. Three new species of remosiid siphonophore (Siphonophora: Physonectae). J Mar Biol Assoc United Kingdom 90: 1119-1143.   DOI
66 Ramsaran H, Chen J, Brunke B, Hill A, Griffiths MW. 1998. Survival of bioluminescent Listeria monocytogenes and Escherichia coli O157:H7 in soft cheeses. J Dairy Sci 81: 1810-1817.   DOI
67 Remy I, Michnick SW. 2006. A highly sensitive protein-protein interaction assay based on Gaussia luciferase. Nat Methods 3: 977-979.   DOI
68 Rodriguez JA, Hooper G. 2019. Adenosine Triphosphate-Bioluminescence Technology as an Adjunct Tool to Validate Cleanliness of Surgical Instruments. AORN J 110: 596-604.   DOI
69 Salih A, Larkum A, Cox G, Kuhl M, Hoegh-Guldberg O. 2000. Fluorescent pigments in corals are photoprotective. Nature 408: 850-853.   DOI
70 Scatena CD, Hepner MA, Oei YA, Dusich JM, Yu SF, Purchio T, et al. 2004. Imaging of bioluminescent LNCaP-luc-M6 tumors: a new animal model for the study of metastatic human prostate cancer. Prostate 59: 292-303.   DOI
71 Scott D, Dikici E, Ensor M, Daunert S. 2011. Bioluminescence and its impact on bioanalysis. Annu Rev Anal Chem (Palo Alto Calif) 4: 297-319.   DOI
72 Amodio E, Dino C. 2014. Use of ATP bioluminescence for assessing the cleanliness of hospital surfaces: a review of the published literature (1990-2012). J Infect Public Health 7: 92-98.   DOI
73 Applegate BM, Kehrmeyer SR, Sayler GS. 1998. A chromosomally based tod-luxCDABE whole-cell reporter for benzene, toluene, ethybenzene, and xylene (BTEX) sensing. Appl Environ Microbiol 64: 2730-2735.
74 Shimomura O. 2005. The discovery of aequorin and green fluorescent protein. J Microsc 217: 1-15.   DOI
75 Shang J, Ye G, Shi K, Wan Y, Luo C, Aihara H, et al. 2020. Structural basis of receptor recognition by SARS-CoV-2. Nature 581: 221-224.   DOI
76 Shen L, Niu J, Wang C, Huang B, Wang W, Zhu N, et al. 2019. High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses. J Virol 93.   DOI
77 Shimomura O. 1979. Structure of the chromophore of Aequorea green fluorescent protein. FEBS Lett 104: 220-222.   DOI
78 Shimomura O. 2012. Bioluminescence: Chemical Principles and Methods. World Scientific., Singapore.
79 Belkin S, Yagur-Kroll S, Kabessa Y, Korouma V, Septon T, Anati Y, et al. 2017. Remote detection of buried landmines using a bacterial sensor. Nat Biotechnol 35: 308-310.   DOI
80 Baba Y, Sato Y, Owada G, Minakuchi S. 2018. Effectiveness of a combination denture-cleaning method versus a mechanical method: comparison of denture cleanliness, patient satisfaction, and oral health-related quality of life. J Prosthodont Res 62: 353-358.   DOI
81 Berger CN, Crepin VF, Roumeliotis TI, Wright JC, Carson D, PevsnerFischer M, et al. 2017. Citrobacter rodentium Subverts ATP Flux and Cholesterol Homeostasis in Intestinal Epithelial Cells In vivo. Cell Metab 26: 738-752 e736.
82 Bhaumik S, Gambhir SS. 2002. Optical imaging of Renilla luciferase reporter gene expression in living mice. Proc Natl Acad Sci U S A 99: 377-382.   DOI
83 Bird MJ, Wijeyeratne XW, Komen JC, Laskowski A, Ryan MT, Thorburn DR, Frazier AE. 2014. Neuronal and astrocyte dysfunction diverges from embryonic fibroblasts in the Ndufs4fky /fky mouse. Biosci Rep 34: e00151.
84 Bomati EK, Manning G, Deheyn DD. 2009. Amphioxus encodes the largest known family of green fluorescent proteins, which have diversified into distinct functional classes. BMC Evol Biol 9: 77.
85 Bou-Abdallah F, Chasteen ND, Lesser MP. 2006. Quenching of superoxide radicals by green fluorescent protein. Biochim Biophys Acta 1760: 1690-1695.   DOI
86 Boyle R. 1667. New Experiments concerning the relation between light and air (in shining wood and fish). Philosophical Transactions Royal Society 2: 605-612.
87 Byun JY, Lee KH, Shin YB, Kim DM. 2019. Cascading Amplification of Immunoassay Signal by Cell-Free Expression of Firefly Luciferase from Detection Antibody-Conjugated DNA in an Escherichia coli Extract. ACS Sens 4: 93-99.   DOI
88 Shimomura O, Masugi T, Johnson FH, Haneda Y. 1978. Properties and reaction mechanism of the bioluminescence system of the deep-sea shrimp Oplophorus gracilorostris. Biochemistry 17: 994-998.   DOI
89 Shimomura O, Johnson FH. 1978. Peroxidized coelenterazine, the active group in the photoprotein aequorin. Proc Natl Acad Sci U S A 75: 2611-2615.   DOI
90 Shimomura O, Johnson FH, Saiga Y. 1962. Extraction, purification and properties of aequorin, a bioluminescent protein from the luminous hydromedusan, Aequorea. J Cell Comp Physiol 59: 223-239.   DOI
91 Sparks JS, Schelly RC, Smith WL, Davis MP, Tchernov D, Pieribone VA, Gruber DF. 2014. The covert world of fish biofluorescence: a phylogenetically widespread and phenotypically variable phenomenon. PLoS One 9: e83259.
92 Stanger-Hall KF, Lloyd JE, Hillis DM. 2007. Phylogeny of North American fireflies (Coleoptera: Lampyridae): implications for the evolution of light signals. Mol Phylogenet Evol 45: 33-49.   DOI
93 Stepanyuk GA, Liu ZJ, Markova SS, Frank LA, Lee J, Vysotski ES, Wang BC. 2008. Crystal structure of coelenterazine-binding protein from Renilla muelleri at 1.7 A: why it is not a calciumregulated photoprotein. Photochem Photobiol Sci 7: 442-447.   DOI
94 Stepanyuk GA, Liu ZJ, Burakova LP, Lee J, Rose J, Vysotski ES, Wang BC. 2013. Spatial structure of the novel light-sensitive photoprotein berovin from the ctenophore Beroe abyssicola in the Ca(2+)-loaded apoprotein conformation state. Biochim Biophys Acta 1834: 2139-2146.   DOI
95 Stults NL, Stocks NF, Rivera H, Gray J, McCann RO, O'Kane D, et al. 1992. Use of recombinant biotinylated aequorin in microtiter and membrane-based assays: purification of recombinant apoaequorin from Escherichia coli. Biochemistry 31: 1433-1442.   DOI
96 Choy G, Choyke P, Libutti SK. 2003. Current advances in molecular imaging: noninvasive in vivo bioluminescent and fluorescent optical imaging in cancer research. Mol Imaging 2: 303-312.   DOI
97 Caceres G, Zankina R, Zhu X, Jiao JA, Wong H, Aller A, Andreotti P. 2003. Determination of chemotherapeutic activity in vivoby luminescent imaging of luciferase-transfected human tumors. Anticancer Drugs 14: 569-574.   DOI
98 Charrier T, Durand MJ, Jouanneau S, Dion M, Pernetti M, Poncelet D, Thouand G. 2011. A multi-channel bioluminescent bacterial biosensor for the on-line detection of metals and toxicity. Part I: design and optimization of bioluminescent bacterial strains. Anal Bioanal Chem 400: 1051-1060.   DOI
99 Chiesa A, Rapizzi E, Tosello V, Pinton P, de Virgilio M, Fogarty KE, Rizzuto R. 2001. Recombinant aequorin and green fluorescent protein as valuable tools in the study of cell signalling. Biochem J 355: 1-12.   DOI
100 Comps-Agrar L, Maurel D, Rondard P, Pin JP, Trinquet E, Prezeau L. 2011. Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to G protein-coupled receptor oligomerization. Methods Mol Biol 756: 201-214.   DOI
101 Cook SH, Griffin DE. 2003. Luciferase imaging of a neurotropic viral infection in intact animals. J Virol 77: 5333-5338.   DOI
102 Cronin M, Sleator RD, Hill C, Fitzgerald GF, van Sinderen D. 2008. Development of a luciferase-based reporter system to monitor Bifidobacterium breve UCC2003 persistence in mice. BMC Microbiol 8: 161.
103 Dale NC, Johnstone EKM, White CW, Pfleger KDG. 2019. NanoBRET: The Bright Future of Proximity-Based Assays. Front Bioeng Biotechnol 7: 56.
104 Dostalek P, Branyik T. 2005. Prospects for rapid bioluminescent detection methods in the food industry - a review. Czech J Food Sci 23: 85-92.   DOI
105 Takai A, Nakano M, Saito K, Haruno R, Watanabe TM, Ohyanagi T, et al. 2015. Expanded palette of Nano-lanterns for real-time multicolor luminescence imaging. Proc Natl Acad Sci U S A 112: 4352-4356.   DOI
106 Suzuki K, Kimura T, Shinoda H, Bai G, Daniels MJ, Arai Y, et al. 2016. Five colour variants of bright luminescent protein for real-time multicolour bioimaging. Nat Commun 7: 13718.
107 Syed AJ, Anderson JC. 2021. Applications of bioluminescence in biotechnology and beyond. Chem Soc Rev 50: 5668-5705.   DOI
108 Sylvia JM, Janni JA, Klein JD, Spencer KM. 2000. Surface-enhanced raman detection of 2,4-dinitrotoluene impurity vapor as a marker to locate landmines. Anal Chem 72: 5834-5840.   DOI
109 Takakura H, Kojima R, Kamiya M, Kobayashi E, Komatsu T, Ueno T, et al. 2015. New class of bioluminogenic probe based on bioluminescent enzyme-induced electron transfer: BioLeT. J Am Chem Soc 137: 4010-4013.   DOI
110 Takenaka Y, Yamaguchi A, Tsuruoka N, Torimura M, Gojobori T, Shigeri Y. 2012. Evolution of bioluminescence in marine planktonic copepods. Mol Biol Evol 29: 1669-1681.   DOI
111 Takenaka Y, Masuda H, Yamaguchi A, Nishikawa S, Shigeri Y, Yoshida Y, Mizuno H. 2008. Two forms of secreted and thermostable luciferases from the marine copepod crustacean, Metridia pacifica. Gene 425: 28-35.   DOI
112 Taminiau A, Draime A, Tys J, Lambert B, Vandeputte J, Nguyen N, et al. 2016. HOXA1 binds RBCK1/HOIL-1 and TRAF2 and modulates the TNF/NF-kappaB pathway in a transcriptionindependent manner. Nucleic Acids Res 44: 7331-7349.   DOI
113 Thompson EM, Nagata S, Tsuji FI. 1989. Cloning and expression of cDNA for the luciferase from the marine ostracod Vargula hilgendorfii. Proc Natl Acad Sci U S A 86: 6567-6571.   DOI
114 Endo M, Ozawa T. 2020. Advanced Bioluminescence System for In vivo Imaging with Brighter and Red-Shifted Light Emission. Int J Mol Sci 21.
115 Dragulescu-Andrasi A, Liang G, Rao J. 2009. In vivo bioluminescence imaging of furin activity in breast cancer cells using bioluminogenic substrates. Bioconjug Chem 20: 1660-1666.   DOI
116 Dubois R. 1885. Fonction photogenique des pyrophores. CR Seances Soc Biol Fil 37: 559-562.
117 Dudgeon DD, Shinde SN, Shun TY, Lazo JS, Strock CJ, Giuliano KA, et al. 2010. Characterization and optimization of a novel protein-protein interaction biosensor high-content screening assay to identify disruptors of the interactions between p53 and hDM2. Assay Drug Dev Technol 8: 437-458.   DOI
118 England CG, Ehlerding EB, Cai W. 2016. NanoLuc: A Small Luciferase Is Brightening Up the Field of Bioluminescence. Bioconjug Chem 27: 1175-1187.   DOI
119 Erikaku T, Zenno S, Inouye S. 1991. Bioluminescent immunoassay using a monomeric Fab'-photoprotein aequorin conjugate. Biochem Biophys Res Commun 174: 1331-1336.   DOI
120 Esteban Florez FL, Hiers RD, Zhao Y, Merritt J, Rondinone AJ, Khajotia SS. 2020. Optimization of a real-time highthroughput assay for assessment of Streptococcus mutans metabolism and screening of antibacterial dental adhesives. Dent Mater 36: 353-365.   DOI
121 Felsenstein J. 1985. Confidence limits on phylogenies: An approach using the bootstrap. Evolution 39: 783-791.   DOI
122 Fourrage C, Swann K, Gonzalez Garcia JR, Campbell AK, Houliston E. 2014. An endogenous green fluorescent proteinphotoprotein pair in Clytia hemisphaerica eggs shows cotargeting to mitochondria and efficient bioluminescence energy transfer. Open Biol 4: 130206.
123 Haddock SH, Dunn CW. 2015. Fluorescent proteins function as a prey attractant: experimental evidence from the hydromedusa Olindias formosus and other marine organisms. Biol Open 4: 1094-1104.   DOI
124 Fukuba T, Aoki Y, Fukuzawa N, Yamamoto T, Kyo M, Fujii T. 2011. A microfluidic in situ analyzer for ATP quantification in ocean environments. Lab Chip 11: 3508-3515.   DOI
125 Gerlach T, Sprenger D, Michiels NK. 2014. Fairy wrasses perceive and respond to their deep red fluorescent coloration. Proc Biol Sci 281.
126 Gruber DF, Loew ER, Deheyn DD, Akkaynak D, Gaffney JP, Smith WL, et al. 2016. Biofluorescence in Catsharks (Scyliorhinidae): Fundamental Description and Relevance for Elasmobranch Visual Ecology. Sci Rep 6: 24751.
127 Haddock SH, Moline MA, Case JF. 2009. Bioluminescence in the sea. Annu Rev Mar Sci 2: 443-493.   DOI
128 Haddock SH, Moline MA, Case JF. 2010. Bioluminescence in the sea. Ann Rev Mar Sci 2: 443-493.   DOI
129 Haddock SH, Dunn CW, Pugh PR, Schnitzler CE. 2005. Bioluminescent and red-fluorescent lures in a deep-sea siphonophore. Science 309: 263.
130 Hall MP, Unch J, Binkowski BF, Valley MP, Butler BL, Wood MG, et al. 2012. Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate. ACS Chem Biol 7: 1848-1857.   DOI
131 Hansen CB, Kerrouche A, Tatari K, Rasmussen A, Ryan T, Summersgill P, et al. 2019. Monitoring of drinking water quality using automated ATP quantification. J Microbiol Methods 165: 105713.
132 Harvey EN. 1957. A history of luminescence from the earliest times until 1900. American Philosophical Society. Philadelphia.