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http://dx.doi.org/10.14406/acu.2013.045

Mutual Inhibitory Effects of Electroacupuncture Applied to Combination of ST36 and PC7 in the Rat Model of Arthritis  

Kim, Yeojung (Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University)
Jung, Yunjung (Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University)
Lee, Chang-Hyung (Department of Rehabilitation Medicine, Pusan National University School of Medicine)
Koo, Sungtae (Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University)
Publication Information
Korean Journal of Acupuncture / v.30, no.4, 2013 , pp. 298-304 More about this Journal
Abstract
Objectives : We examined mutual inhibitory effects of combined acupoints in arthritic pain induce by carrageenan(CA). Electroacupuncture(EA) is considered a potentially useful treatment for arthritis. Although the analgesic effect of acupuncture is well documented, little is understood about its biological basis. There are many previous studies of positive effect of combined acupoint, this study was conducted to see the mutual inhibitory effects produced by combined acupoint(ST36 and PC7) on arthritic rats. Methods : For the induction of inflammatory pain rat model, CA was injected into the knee joint cavity. There are four groups; EA was applied to bilateral PC7 acupoints(PC7 group), ST36 acupoints(ST36 group), and both PC7 and ST36 acupoints(ST36+PC7 group) except for the control group. The pain level were assessed to determine the change in weight bearing force. We also examined the COX-2 expression in dorsal horn using immunohistochemistry and western blot analysis. Results : The ST36+PC7 group data showed the significant reduction of weight bearing force and the induction of COX-2 protein expression compared with the ST36 group. Conclusions : Simultaneous EA applied to the ST36 and PC7 acupoints reduced the analgesic effect of the ST36 group on knee inflammatory pain.
Keywords
carrageenan induced arthritis; electroacupuncture; weight bearing; COX-2;
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Times Cited By KSCI : 2  (Citation Analysis)
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