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http://dx.doi.org/10.14406/acu.2013.049

The Effect of Stephaniae tetrandrae Radix Herbal-acupuncture at KI10 on LPS Induced Nephritis in Rats  

Kim, Ki-Choon (Department of Meridian and Acupoint, College of Korean Medicine, Daejeon University)
Yim, Yun-Kyoung (Department of Meridian and Acupoint, College of Korean Medicine, Daejeon University)
Publication Information
Korean Journal of Acupuncture / v.30, no.4, 2013 , pp. 281-288 More about this Journal
Abstract
Objectives : This study aimed to evaluate the effects of Stephaniae tetrandrae Radix Herbal-acupuncture(SR-HA) at KI10(Umgok) on nephritis induced by lipopolysaccharide(LPS) in rats. Methods : Male SD rats (n=32) were allocated to four groups; normal, LPS, saline, and SR-HA. The rats in the LPS, saline, and SR-HA groups were injected intra-peritoneally with LPS (2 mg/kg) to induce nephritis. The rats in the saline and SR-HA groups were treated with saline injection and SR-HA respectively at KI10 three times a week. To evaluate the effects of SR-HA at KI10 on nephritis in rats, the authors evaluated the numbers of WBC and neutrophils in blood, and the levels of creatinine, TNF-${\alpha}$, CINC-1 in serum, creatinine, total protein in urine and renal MPO. Results : SR-HA at KI10 significantly inhibited the increase of WBC and neutrophils in blood, TNF-${\alpha}$, CINC-1 in serum, creatine, total protein in urine and MPO in kidney of LPS-stimulated rats. Conclusions : SR-HA at KI10 may have therapeutic effects on nephritis in LPS-stimulated rats.
Keywords
nephritis; herbal-acupuncture; KI10; Stephaniae tetrandrae Radix; LPS;
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Times Cited By KSCI : 2  (Citation Analysis)
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