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http://dx.doi.org/10.18325/jkmr.2020.30.3.45

The Effects of ChondroT on Thrombus in FeCl3-induced Rats  

Kim, Ji Hoon (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongshin University)
Kim, Sun Gil (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongshin University)
Kim, Joo Il (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongshin University)
Yoon, Chang Suk (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongshin University)
Choi, Ji Min (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongshin University)
Na, Chang Su (Department of Meridian and Acupoint, College of Korean Medicine, Dongshin University)
Kim, Seon Jong (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongshin University)
Publication Information
Journal of Korean Medicine Rehabilitation / v.30, no.3, 2020 , pp. 45-56 More about this Journal
Abstract
Objectives This study was designed to investigate the effects of ChondroT on thrombus in FeCl3-induced rats. Methods We exposed FeCl3 to rat's carotid artery to induce thrombus. Specimens were divided in 5 groups; Intact, Control, ASA10 (aspirin 10 mg/kg), CT100 (ChondroT 100 mg/kg), and CT200 (ChondroT 200 mg/kg), each n=6. We investigated thromboxane, platelet activating factor (PAF), histological change, lipid metabolism, transaminase, leukocyte, erythrocyte and thrombocyte level. Results In ASA10, CT200 groups, there was significants decrease in both thromboxane level and total cholesterol level, compared to control group and there were significant histological changes of blood vessel, compared to control group. In CT200 group, there was significant decrease in PAF level, compared to control group (p<0.05). In ASA10, CT200 groups, triglycerides level tended to decrease, compared to control group. Conclusions Based on these results, it could be suggested that ChondroT was effective on thrombus in FeCl3-induced rats, and further study is needed to conduct a rigorous clinical research.
Keywords
ChondroT; Thrombosis; Herbal medicine; $FeCl_3$;
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Times Cited By KSCI : 5  (Citation Analysis)
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