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http://dx.doi.org/10.18325/jkmr.2020.30.1.105

The Effects of Aronia Extract on Body Weight and Body Fat: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial  

Ha, Ki Chan (Healthcare Claims & Management Inc.)
Park, Yu Kyung (Healthcare Claims & Management Inc.)
Baek, Hyang Im (Healthcare Claims & Management Inc.)
Kim, Hye Mi (Healthcare Claims & Management Inc.)
Kim, Young Mi (Healthcare Claims & Management Inc.)
Jeong, Da Young (Healthcare Claims & Management Inc.)
Shin, Sang Wook (Healthcare Claims & Management Inc.)
Bae, Jung Shik (Wellfine Co., Ltd.)
An, Ji Hye (Wellfine Co., Ltd.)
Jeon, Yeon Jeong (Wellfine Co., Ltd.)
Park, Ji Eun (Wellfine Co., Ltd.)
Kwon, Young Dal (Department of Korean Rehabilitation Medicine, Gwangju Medical Center, College of Korean Medicine, Wonkwang University)
Publication Information
Journal of Korean Medicine Rehabilitation / v.30, no.1, 2020 , pp. 105-113 More about this Journal
Abstract
Objectives Excess weight and obesity are a crucial public health problem worldwide and are considered as the main cause of many chronic diseases. The present study evaluated the effects of Aronia melanocarpa extract (AMEX) supplementation on body compositions in overweight or obese people. Methods This randomized, double-blind, placebo-controlled clinical trial was carried out on 66 healthy overweight or obese peoples. The eligible subjects were divided into AMEX and placebo supplement treatment for 12 weeks. Anthropometrics, body composition (dual-energy X-ray absorptiometry), and blood analysis were performed preand post intervention. Results We observed significant reductions in the body weight and body mass index in both groups; however, the decrease was higher in the AMEX group. Body fat mass and percent body fat showed a tendency to decreases after AMEX supplementation. No clinically significant changes were observed for any safety parameter. Conclusions In conclusion, the data of this trial indicate that AMEX were not effective in reducing body compositions, but as a safe supplement, it may help weight loss in overweight or obese people.
Keywords
Aronia melanocarpa; Overweight; Obesity; Body mass index; Weight loss;
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1 Won JS, Cho SY, Lim DS, Choi YJ, Song MK, Kim HY, Kim SI, Kim YT. Key findings of the 2018 community health survey. Public Health Weekly Report. 2019;12(17):516-22.
2 Silventoinen K, Rokholm B, Kaprio J, Sorensen TI. The genetic and environmental influences on childhood obesity: A systematic review of twin and adoption studies. Int J Obes (Lond). 2010;34:29-40.   DOI
3 Amin MM, Ebrahim K, Hashemi M, Shoshtari-Yeganeh B, Rafiei N, Mansourian M, Kelishadi R. Association of exposure to bisphenol A with obesity and cardiometabolic risk factors in children and adolescents. Int J Environ Health Res. 2019;29:94-106.   DOI
4 Scherer PE, Hill JA. Obesity, diabetes, and cardiovascular diseases: a compendium. Circ Res. 2016;118:1703-5.   DOI
5 Boccellino M, Di Domenico M, Donniacuo M, Bitti G, Gritti G, Ambrosio P, Quagliuolo L, Rinaldi B. AT1-receptor blockade: protective effects of irbesartan in cardiomyocytes under hypoxic stress. PLoS ONE. 2018;13:e0202297.   DOI
6 Jack BU, Malherbe CJ, Mamushi M, Muller CJF, Joubert E, Louw J, Pheiffer C. Adipose tissue as a possible therapeutic target for polyphenols: A case for Cyclopia extracts as anti-obesity nutraceuticals. Biomedicine & Pharmacotherapy. 2019;120:109439.   DOI
7 D'Archivio M, Filesi C, Di Benedetto R, Gargiulo R, Giovannini C, Masella R. Polyphenols, dietary sources and bioavailability. Ann Ist Super Sanita. 2007;43(4):348-61.
8 Manach C, Scalbert A, Morand C, Remesy C, Jimenez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr. 2004;79(5):727-47.   DOI
9 Kokotkiewicz A, Jaremicz Z, Luczkiewicz M. Aronia plants: a review of traditional use, biological activities, and perspectives for modern medicine. J Med Food. 2010;13(2):255-69.   DOI
10 Oszmianski J, Wojdylo A. Aronia melanocarpa phenolics and their antioxidant activity. Eur Food Res Technol. 2005;221:809-13.   DOI
11 Zheng W, Wang SY. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem. 2003;51(2):502-9.   DOI
12 Ohgami K, Ilieva I, Shiratori K, Koyama Y, Jin XH, Yoshida K, Kase S, Kitaichi N, Suzuki Y, Tanaka T, Ohno S. Anti-inflammatory effects of aronia extract on rat endotoxin-induced uveitis., Invest Ophthalmol Vis Sci. 2005;46(1):275-81.   DOI
13 Valcheva-Kuzmanova S, Borisova P, Galunska B, Krasnaliev I, Belcheva A. Hepatoprotective effect of the natural fruit juice from Aronia melanocarpa on carbon tetrachloride-induced acute liver damage in rats. Exp Toxicol Pathol. 2004;56:195-201.   DOI
14 Kulling SE, Rawel HM. Chokeberry (Aronia melanocarpa)-A review on the characteristic components and potential health effects. Planta Med. 2008;74:1625-34.   DOI
15 Naruszewicz M, Laniewska I, Millo B, Dluzniewski M. Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infraction (MI). Atherosclerosis. 2007;194:179-84.
16 Valcheva-Kuzmanova S, Kuzmanov K, Mihova V, Krasnaliev I, Borisova P, Belcheva A. Antihyperlipidemic effect of Aronia melanocarpa fruit juice in rats fed a high-cholesterol diet. Plant Foods Hum Nutr. 2007;62:19-24.   DOI
17 Kim NY, Lee JM, Lee JY, Lee HY. Enhancement of anti-obesity activities of Aronia melanocarpa elliot extracts from low temperature ultrasonification process. Korean J Medicinal Crop Sci. 2016;24(4):309-16.   DOI
18 Kim NH, Jegal J, Kim YN, Heo JD, Rho JR, Yang MH, Jeong EJ. Chokeberry extract and its active polyphenols suppress adipogenesis in 3T3-L1 adipocytes and modulates fat accumulation and insulin resistance in diet-induced obese mice. Nutrients. 2018;10(11):1734-47.   DOI
19 Lim SM, L ee HS, J ung J I, Kim SM, Kim NY, Seo TS, Bae JS, Kim EJ. Cyanidin-3-O-galactoside-enriched Aronia melanocarpa extract attenuates weight gain and adipogenic pathways in high-fat diet-induced obese C57BL/6 mice. Nutrients. 2019;11(5):1190-205.   DOI
20 Bray GA. Medical consequences of obesity. J Clin Endocrinol Metab. 2004;89(6):2583-9.   DOI
21 Araghi MH, Jagielski A, Neira I, Brown A, Higgs S, Thomas GN, Taheri S. The complex associations among sleep quality, anxiety-depression, and quality of life in patients with extreme obesity. Sleep. 20131;36(12):1859-65.   DOI
22 Skoczynska A, Jedrychowska I, Aelska A, Turczyn B, Wojakowska A, Andrzejak R. Influence of chokeberry juice on arterial blood pressure and lipid parameters in men with mild hypercholesterolemia. Pharmacol Rep. 2007;6:177-82.
23 Shin SM. Management of overweight and obesity: review of the "2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults". Korean J Med. 2014; 82(2):136-41.   DOI