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Effects of Fermented Lotus Extracts on Glucose Intolerance and Lipid Metabolism-related Gene Expression  

Kim, Hyung-Gu (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dongguk University)
Bose, Shambhunath (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dongguk University)
Kim, Dong-Il (Department of Obstetrics and Gynecology, College of Oriental Medicine, Dongguk University)
Koo, Byung-Soo (Department of Neuropsychiatry, College of Oriental Medicine, Dongguk University)
Kim, Hojun (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dongguk University)
Publication Information
Journal of Korean Medicine Rehabilitation / v.24, no.1, 2014 , pp. 1-12 More about this Journal
Abstract
Objectives This study was performed to evaluate the effects of fermented lotus extracts on prediabetes and hyperlipidemia in high fructose diet rats. Methods Extracts of lotus leaf and lotus root were fermented using 4 different probiotics separately, including Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium breve, and Bifidobacterium longum. Expressions of adipogenic transcription factors including Adiponectin, GLUT-4, Leptin, PPAR gamma, Resistin and Visfatin were analyzed by Real time PCR and Western blotting analysis. Results Fermented lotus extracts reduced blood glucose. Fermented lotus extracts inhibited adipogenic transcription factors by inhibiting preadipocytes differentiation. The level of gene expression of Adiponectin, GLUT-4, Leptin, PPAR gamma, Resistin and Visfatin in relation to that of GAPDH were increase or decrease significantly with the Fermented lotus formulation group. Conclusions Fermented lotus extracts showed hypoglycemic and hypolipidemic effects by inhibiting preadipocyte differentiation and controlling insulin sensitivity in high fructose diet rats.
Keywords
Lotus; Probiotics; Fermentation; Insulin resistance; Hyperlipidemia;
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Times Cited By KSCI : 6  (Citation Analysis)
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