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Single Oral Dose Toxicity of TB001 in Rats  

Cha, Yun-Yeop (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Sang-Ji University)
Sun, Seung-Ho (Dept. of Oriental internal Medicine, College of Oriental Medicine, Sang-Ji University)
Park, Won-Hyung (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Sang-Ji University)
Park, Dong-Sik (Functional Food and Nutrition Division, National Academy of Agricultural Science, Rural Development Administration)
Kim, Jae-Hyun (Functional Food and Nutrition Division, National Academy of Agricultural Science, Rural Development Administration)
Kim, Hee-Yeon (Gangwon Provincial Agricultural Research & Extention Services)
Lim, Sang-Hyun (Gangwon Provincial Agricultural Research & Extention Services)
Kim, Kyung-Hee (Gangwon Provincial Agricultural Research & Extention Services)
Publication Information
Journal of Korean Medicine Rehabilitation / v.21, no.4, 2011 , pp. 41-47 More about this Journal
Abstract
Objectives: This study was performed to investigate single oral dose toxicity of TB001, the extract mixture of Purple loosestrife and Aceriphyllum rossii. Methods: The mortality, general symptom, change of weight: and necropcy findings was investigated for 14 days after a dose(2000 mg/kg B.W.) of TB001 was given, using SD rats of both male and female according to "The guideline of toxicity test for medicine and others". Results: The death of rats and abnormal finding was not observed. There was no the significant difference of weight between control group and TB001 group. Conclusions: The abnormalities at the necropsy finding of all survived rats was not detected. The study suggested that there is no toxicity in single dose(2000 mg/kg B.W.) of TB001.
Keywords
TB001; Single oral dose toxicity; Purple loosestrife; Aceriphyllum rossii;
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Times Cited By KSCI : 6  (Citation Analysis)
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