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Association of GNB3 Polymorphism with Obesity Index, Blood Pressure, Glucose and Lipid Level  

Kwon, Dong-Hyun (Dept. of Oriental Rehabilitation Medicine, Graduate School, Dong-Guk University)
Park, Jung-Hyun (Dept. of Oriental Rehabilitation Medicine, Graduate School, Dong-Guk University)
Lee, Myeong-Jong (Dept. of Oriental Rehabilitation Medicine, Graduate School, Dong-Guk University)
Song, Mi-Young (Dept. of Oriental Rehabilitation Medicine, Graduate School, Dong-Guk University)
Kim, Ho-Jun (Dept. of Oriental Rehabilitation Medicine, Graduate School, Dong-Guk University)
Publication Information
Journal of Korean Medicine Rehabilitation / v.21, no.4, 2011 , pp. 157-165 More about this Journal
Abstract
Objectives: The aim of this study is to establish the association of GNB3 with obesity-index, blood pressure, glucose and lipid level. Methods: A total of 209 Korean obese subjects participated in the study. Body weight, body mass index(BMI), waist circumference, body fat, body fat mass, resting metabolic rate, blood pressure, total cholesterol, high density lipoprotein, triglyceride and fasting blood sugar test were measured by using standardized protocols. The GNB3 was genotyped by using polymerase chain reaction with restriction fragment length polymorphism. Results: The frequency of CC, CT, TT genotype were, respectively, 18,2%, 56.9%, 24,9%, and the frequency of T allele was 53.3% in Korean obese population. There were no association of GNB3 with obesity index, blood pressure, glucose and lipid level in Korean obese population. Conclusions: Obese Korea population have a higher frequency of T alle than general Korean population. There are no association of GNB3 with obesity index, blood pressure, glucose and lipid level in Korean obese population.
Keywords
GNB3 polymorphism; Obesity; Hypertension;
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