Effects of Root of Scutellariae Radix against Inflammatory Response in the Spinal Cord Contusion Injury in Rats
![]() |
Yang, Kee-Young
(Dept. of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung-Hee University)
Choi, Won-Ik (Dept. of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung-Hee University) Shin, Jung-Won (Dept. of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung-Hee University) Park, Seong-Ha (Dept. of Internal Medicine, School of Korean Medicine, Pusan National University) Kim, Seong-Joon (Dept. of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung-Hee University) Lee, Jong-Soo (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung-Hee University) Sohn, Nak-Won (Dept. of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung-Hee University) |
1 | Deumens R, Joosten EA, Waxman SG, Hains BC. Locomotor dysfunction and pain: the scylla and charybdis of fiber sprouting after spinal cord injury. Mol Neurobiol. 2008;37:52-63. DOI ScienceOn |
2 | Kalous A, Osborne PB, Keast JR. Acute and chronic changes in dorsal horn innervation by primary afferents and descending supraspinal pathways after spinal cord injury. J Comp Neural. 2007;504:238-53. DOI ScienceOn |
3 | 이준규. 척추 손상의 병태생리학. 대한척추외과학회지. 2009;16(1):64-70. |
4 | Kwon BK, Tetzlaff W, Grauer JN, Beiner J, Vaccaro AR. Pathophysiology and pharmacologic treatment of acute spinal cord injury. Spine. 2004;4:451-64. DOI ScienceOn |
5 | Donovan WH. Operative and nonoperative management of spinal cord injury. Paraplegia. 1994;32:375-88. DOI ScienceOn |
6 | 양준영, K. Daniel Riew. 쥐의 척수손상 후 사이토카인 발현 연구를 통한 세포 사멸을 조절하는 길항제의 연구. 대한정형외과학회지. 2007;42(1):106-14. |
7 | Popovich PC, Wei P, Stokes BT. Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats. J Comp Neural. 1997;377(3):443-64. DOI ScienceOn |
8 | Tracey KJ, Cerami A. Tumor necrosis factor in metabolism of disease: hormonal actions versus local tissue effects. Nouv Rev Fr Hematol. 1992;34 Suppl:S37-42. |
9 | Tracey KJ, Fong Y, Hesse DC, Manogue KR, Lee AT, Kuo GC, Lowry SF, Cerami A. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature. 1987;330(6149):662-4. DOI ScienceOn |
10 | Baker SJ, Reddy EP. Modulation of life and death by the TNF receptor superfamily. Oncogene. 1998;17(25):3261-70. DOI |
11 | Karupiah G, Xie QW, Buller RM, Nathan C, Duarte C, MacMicking JD. Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase. Science. 1993;261(5127):1445-8. DOI ScienceOn |
12 | Blackburn D, Sargsyan S, Monk PN, Shaw PJ. Astrocyte function and role in motor neuron disease: a future therapeutic target. Glia. 2009;57:1251-64. DOI ScienceOn |
13 | 박원상, 김은석, 신정원, 김범회, 김성준, 강희, 손낙원. 狗春이 흰쥐의 척수압막에 의한 신경세포 손상에 미치는 영향. 한방재활의학과학회지. 2010;20(2):1-15. |
14 | 성주원, 김기역, 반효정, 신정원, 강희, 김성준, 손낙원. 黃連解靑湯이 척수 압박손상 흰쥐의 운동기능 장애에 미치는 영향. 한방재활의학과학회지. 2010;20(4):1-15. |
15 | 전국한의과대학 본초학교수 공편. 본초학. 서울:영림사. 2000:218-9. |
16 | Choi J, Conrad CC, Malakowsky CA, Talent jM, Yuan CS, Gracy RW. Flavones from Scutellaria baicalensis Georgi attenuate apoptosis and protein oxidation in neuronal cell lines. Biochim Biophys Acta. 2002;1571:201-10. DOI ScienceOn |
17 | Young W. Spinal cord contusion models. Prog Brain Res. 2002;137:231-55. |
18 | Kim EH, Shim B, Kang S, Jeong G, Lee JS, Yu YB, Chun M. Anti-inflammatory effects of Scutellaria baica1ensis extract via suppression of immune modulators and MAP kinase signaling molecules. J Ethnopharmacol. 2009;126:320-31. DOI ScienceOn |
19 | Mu X, He G, Cheng Y, Li X, Xu B, Du G. Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro. Pharmacol Biochem Behav. 2009;92:642-8. DOI ScienceOn |
20 | Zhang Y, Wang X, Wang X, Xu Z, Liu Z, Ni Q, Chu X, Qiu M, Zhao A, Jia W. Protective effect of flavonoids from Scutellaria baicalensis Georgi on cerebral ischemia injury. J Ethnopharmacol. 2006;108:355-60. DOI ScienceOn |
21 | Liu XZ, Xu XM, Hu R, Du C, Zhang SX, McDonald JW, Dong HX, Wu YJ, Fan GS, Jacquin MF, Hsu CY, Choi DW. Neuronal and glial apoptosis after traumatic spinal cord injury. J Neurosci. 1997;17:5395-406. |
22 | Springer JE, Azbill RD and Knapp PE. Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury. Nat Med. 1999;5:943-6. DOI ScienceOn |
23 | Casha S, Yu WR, Fehlings MG. Oligodendroglial apoptosis occurs along degenerating axons and is associated with FAS and P75 expression following spinal cord injury in the rat. Neuroscience. 2001;103:203-18. DOI ScienceOn |
24 | Bareyre FM, Schwab ME. Inflammation, degeneration and regeneration in the injured spinal cord: insights from DNA microarrays. Trends Neurosci. 2003;26:555-63. DOI ScienceOn |
25 | Bao F, Liu D. Hydroxyl radicals generated in the rat spinal cord at the level produced by impact injury induce cell death by necrosis and apoptosis: protection by a metalloporphyrin. Neuroscience. 2004;126:285-95. DOI ScienceOn |
26 |
Braughler JM, Hall ED. Correlation of methylprednisolone levels in cat spinal cord with its effects on (Na |
27 | Braughler JM, Hall ED, Means ED, Waters TR, Anderson DK. Evaluation of an intensive methylprednisolone sodium succinate dosing regimen in experimental spinal cord injury. J Neurosurg. 1987;67:102-5. DOI |
28 | Lowenstein CJ, Dinerman JL, Snyder SH. Nitric oxide: a physiologic messenger. Ann Intern Med. 1994;120:227-37. DOI ScienceOn |
29 | Dustin J Donnelly, Phillip G. Popovich. Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury. Exp Neurol. 2008;209(2):378-88. DOI ScienceOn |
30 | Garau A, Bertini R, Colotta F, Casilli F, Bigini P, Cagnotto A, Mennini T, Ghezzi P, Villa P. Neuroprotection with the CXCL8 inhibitor repertaxin in transient brain ischemia. Cytokine. 2005;30:125-31. DOI ScienceOn |
31 | Pannu R, Singh J. Pharmacological strategies for the regulation of inducible nitric oxide synthase: neurodegenerative versus neuroprotative mechanisms. Neurochem Int. 2006;49:170-82. DOI ScienceOn |
32 | Hamada Y, Ikata T, Katoh S, Tsuchiya K, Niwa M, Tsutsumishita Y, Fukuzawa K. Roles of nitric oxide in compression injury of rat spinal cord. Free Radical Biol Med. 1996;20:1-9. DOI ScienceOn |
33 | Schnell L, Fearn S, Klassen H, Schwab ME, Perry VH. Acute inflammatory responses to mechanica1 lesions in the CNS: differences between brain and spinal cord. Eur J Neurosci. 1999;11:3648-58. DOI ScienceOn |
34 | Yune TY, Lee JY, Cui CM, Kim HC, Oh TH. Neuroprotectivc effect of Scutellaria baicalensis on spinal cord injury in rats. J Neurochem. 2009;110:1276-87. DOI ScienceOn |
35 | Zeng Y, Song C, Ding X, Ji X, Yi L, Zhu K. Baicalin reduces the severity of experimental autoimmune encephalomyelitis. Braz J Med Biol Res. 2007;40:1003-10. DOI |
![]() |