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Effects of Yeast Fermented Ganoderma Lucidum Extract on the Recovery of Exercise Fatigue in Forced Swimming Rats  

Park, Ji-Hun (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dong-Guk University)
Kim, Ho-Jun (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dong-Guk University)
Lee, Myeong-Jong (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dong-Guk University)
Publication Information
Journal of Korean Medicine Rehabilitation / v.20, no.4, 2010 , pp. 17-31 More about this Journal
Abstract
Objectives : Ganoderma Lucidum has been used in traditional oriental medicine to treat various conditions including chronic fatigue and cough. This experimental study was designed to investigate the effects of yeast-fermented Ganoderma Lucidum extract on the fatigue of rats elicited by forced swimming. Materials and methods : The rat subjects were divided into 4 groups: normal group, control group administered with 0.9% normal saline, experimental I(Exp I) group administered with yeast-fermented Ganoderma lucidum extract and experimental II(Exp II) group administered with Ganoderma lucidum extract for 4 weeks. All the serum samples collected by heart puncture were used to measure biochemical factors such as glucose, lactate, lactate dehydrogenase(LDH), creatine kinase(CK), inorganic phosphorus, ammonia, total cholesterol(TC), triglycerides(TG), high-density lipoprotein(HDL), low-density lipoprotein(LDL), aspartate transaminase(AST), alanine transaminase(ALT). Results : 1. Weight change and swimming time were not significantly different in the experimental groups as compared with control group. 2. Lactate was significantly decreased in the experimental groups as compared with control group. Inorganic phosphorus was also significantly decreased in the Exp I group as compared with control group(p<0.05). 3. Serum lipid concentration was not significantly different in the experimental groups as compared with control group. 4. AST and ALT were significantly decrease in the experimental groups as compared with control group. Conclusions : Yeast-fermented Ganoderma lucidum in forced swimming rats would appear to reduce fatigue-related factors, AST, ALT of serum and promote anti-fatigue effect.
Keywords
Ganoderma lucidum; Yeast-fermented; Forced swimming; Anti-fatigue;
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1 Health magazine. 2006. Available from: URL : http://eating.health.com/tag/health-magazine-march-2006/.
2 김용미. 발효한약의 연구동향 연구. 경원대학교 한의학과대학원. 2009.
3 馬繼興. 神農本草經集註. 北京:人民衛生出版社. 1995:85-8.
4 신민교. 임상본초학. 서울:영림사. 1997:645.
5 江蘇中醫學院. 中藥大靜典. 上海:上海科學技術出版社. 1988:29-30, 1180-2, 2232-5.
6 孫素蘭, 兪勵平, 文浩, 葉靑山, 朱建梅. 灵芝片抗病勞作用實驗硏究. 食品与藥品. 2006;8(6):44-5.
7 徐家玉, 候蘊華, 曾令福, 吳紫華. 灵芝茶對小鼠的抗疲勞作用硏究. 現代預防医學. 1998;25(3):304-5.
8 주현규, 김성조. 영지추출물이 효모의 증식과 생리에 미치는 영향. 한국균학회지. 1987;15:260-7.
9 김종우, 김인대. 영지추출물이 유당발효성 효모의 발효에 미치는 영향. 충남대학교 농지연보. 1995;22(1):54-61.
10 황유연, 정명수, 김혜자, 이기남. 미생물 발효 영지버섯 추출액의 다당체에 관한 연구. 동의생리병리학회지. 2007;21(6):1506-12.   과학기술학회마을
11 이명천, 김기진, 김미혜, 박현, 이대택, 차광석. 스포츠 영양학. 서울:라이프사이언스. 2003:10, 77.
12 楊維傑. 黃帝內經 素問 譯解. 서울:일중사. 1991:210-1.
13 上海中醫學院. 內科學. 香港;商務印書館. 1997:126, 132-3, 136.
14 김완희. 신생리학총론. 서울:경희대학교 한방생리학교실. 1988:14, 59.
15 정승용, 김성애, 김성희, 김한수, 김군자, 김희숙, 정효숙. 영지열수추출액이 식이성 고콜레스테롤 혈증 흰쥐의 지질대사에 미치는 영향. 한국영양식량학회지. 1990;19(2):180-6.
16 Kikuchi T, Kanomi S, Kadota, S, Mural T, Yubono K, Ogita Z. Chem Pharm Bull. 1986;34:4030-403.   DOI
17 Shiao MS, KR Lee, JJ Lin, CT Wang. Phytochemicals for cancer prevention II. p.342. In:CT Ho, eds. Teas, spices and herbs. Washington:American Chemical Society. 1994:342.
18 박지훈, 박정현, 이정호, 김선종, 신미숙, 최진봉. 제호탕 및 영지추출물 투여가 고강도 운동백서의 피로회복에 미치는 영향. 한방재활의학과학회지. 2007;17(4):55-73.
19 Kyungah Jung, In-Ho Kim, Daeseok Han. Effect of medicinal plant extracts on forced swimming capacity in mice. Journal of Ethnopharmacology. 2004;93:75-81.   DOI   ScienceOn
20 Walberg JL, Greenwood MRC, Sterm JS. Lipoprotein lipase activity and lipolysis after swim training in obese Zucker rats. American Journal of Physiology. 1983;245(14):706-12.
21 Drup AE, Saris WH, Wagenmakers JM. Fat metabolization during exercise: A review part I: Fatty acid mobilization and muscle metabolism. Int. J. Sports med. 1995;1:56-90.
22 Rasmussen LO, Christiansen FC, Thomsen C, Hermansen K. Differential effects of saturated and monounsaturated fat on blood glucose and insulin responses in subjects with non-insulin dependent diabetes mellitus. Am. J. Clin. Nutr. 1996;63(2):249-53.
23 Flynn MG, Costill DL, Kirwan JP, Mitchell JB, Houmard JA, Fink WJ, Beltx JD, O'Acquisto LJ. Fat storage in athletes: metabolic and hormonal response to swimming and running. Int. J. Sports Med. 1990;11:433-40.   DOI
24 Clarkson PM, K Nosaka, B Braun. Muscle function after exercise-induced muscle damage and rapid adaptation. Med. Sci. Sports Exerc. 1992;24:512-20.
25 Cocyle EF. Carbohydrate feeding during prolonged strenuous exercise can delay fatigue. J. Appl. Physiol. 1983;55:230.
26 Wilber CG. Some factors which are correlated with swimming capacity in guinea pigs. Journal of Applied Physiology. 1959;14(2):199-203.
27 Sorichter S, Puschendorf B, Mair J. Skeletalmuscle injury induced by eccentric muscle action: muscle proteins as markers of muscle fiber injury. Exerc Immunol Rev. 1999;5:5-21.
28 Everse J, Kaplan NO. Mechanism of action and biological function of various dehydrogenase isozymes. IN:CL Markert, eds. Isozymes physiological function. New York:Academic. 1975:29-44.
29 박철빈, 이상민, 박수연. 운동수행시 혈청효소 변화 분석. 체육학논문집. 2000:28.
30 Karamizrak SO, Ergen E, Tore IR, Akgun N. Changes in serum creatine kinase, lactate dehydrogenase and aldolase activities following supramaximal exercise in athletes. J. Sports Med. Phys. Ritness. 1994;34(2):141-6.
31 Guth H. Potter JD. Effect of rigor and cycling cross-bridges on the structure of troponin C and the Ca2+ affinity of the Ca2+ - specific regulatory sites in skinned rabbit psoas fibers. J. Biol. Chem. 1987;262:13627-35.
32 Walker JW, Lu Z, Swartz D, Moss RL. Thin filament modulation of cross-bridge transition measured by photogeneration of Pi in skeletal muscle fibers. Biophys. J. 1991;59:418a.
33 Coggin A. Plasma glucose metabolism during exercise in humans. Sports medicine. 1991;11:102-24.   DOI   ScienceOn
34 Itoh H, Ohkuwa T. Peak blood ammorua and lactate after submaximal, maximal and supramaximal exercise in sprinters and long-distance runners. Eur J Appl Physiol Occup Physiol. 1990;60(4):271-6.   DOI   ScienceOn
35 Park SJ. The influence of Ganoderma Lucidum added to high lipid diet on adult rat's body content. Master's thesis of Keimyung Univ. 1988:15-6.
36 주현규, 김성조. 영지추출물이 효모의 증식과 생리에 미치는 영향. 한국균학회지. 1987;15:260-7.
37 Lim SJ, Won SB. Effects of korean wild vegetables on blood glucose levels and energy metabolites in streptozotocin induced diabetic rats. 1997;13(5):639-47.
38 박기문, 강국희, 최윤주, 이재영. 발효 유제품에 있어서 유산균과 효모의 상호 작용. 한국미생물생명공학회 학술대회지. 1979:246-7.
39 박정훈, 강만식, 김홍일, 정봉현, 이광호, 문원국. 효모 변이주 Saccharomyces cerevisiae182 세포벽 유래의 ${\beta}$-glucan 면역 활성능에 관한 연구. 한국식품과학회지. 2003;35(3):488-92.   과학기술학회마을
40 주현규, 이종근. 영지의 수용성 추출물이 Saccharomyces cerevisiae의 고급 Alcohol 생성에 미치는 영향. 한국식품과학회지. 1988;20:52-8.
41 김주택. 영지 및 인삼 추출물이 Saccharomyces cerevlslae의 증식과 발효에 미치는 영향. 건국대학교 농화학과 대학원. 1988.
42 JH Kim, DH Lee, SH Lee. Effect of Ganoderma lucidum on the quality and functionality of Korean traditional rice wine, Yakju. Journal of Bioscience and Bioengineering. 2004;97(1):24-8.   DOI
43 이주경. 박하, 산사, 영지, 운지가 유산균의 생육에 미치는 영향. 동국대학교 대학원 식품공학과. 2002.
44 周洪波. 靈芝多糖液體醱酵條件的硏究. 現代生物醫學進展. 2007;7(6):830-2.