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http://dx.doi.org/10.9713/kcer.2022.60.4.544

Negative Pressure Cavitation Acetone-Pentane Fractional Precipitation for the Purification of Paclitaxel from Taxus chinensis  

Min, Hye-Su (Center for Future Sustainable Technology, Department of Chemical Engineering, Kongju National University)
Kim, Jin-Hyun (Center for Future Sustainable Technology, Department of Chemical Engineering, Kongju National University)
Publication Information
Korean Chemical Engineering Research / v.60, no.4, 2022 , pp. 544-549 More about this Journal
Abstract
This study presents the negative pressure cavitation acetone-pentane fractional precipitation to dramatically improve the precipitation efficiency of paclitaxel from Taxus chinensis. When paclitaxel was precipitated under a negative pressure of -200 mmHg, most paclitaxel (>99.9%) could be recovered in a short precipitation time (5 min). The precipitation rate constant increased by 1.512~5.073 times (at -50 mmHg to -200 mmHg) compared to the control. The activation energy decreased by -3,737~-6,536 J/mol due to negative pressure, which increased the precipitation rate. With the introduction of negative pressure, the precipitate size decreased by 5.3 times, and the diffusion coefficient of paclitaxel increased by 7.0 times.
Keywords
Paclitaxel; Acetone-pentane fractional precipitation; Negative pressure; Cavitation; Kinetics;
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Times Cited By KSCI : 1  (Citation Analysis)
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