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http://dx.doi.org/10.9713/kcer.2022.60.1.169

A Tandem Water and Hexane Washing Method for Economical Recovery of Paclitaxel from Biomass  

Lee, Myeong-Gi (Department of Chemical Engineering, Kongju National University)
Kim, Jin-Hyun (Department of Chemical Engineering, Kongju National University)
Publication Information
Korean Chemical Engineering Research / v.60, no.1, 2022 , pp. 169-174 More about this Journal
Abstract
In this study, a tandem water and hexane washing process was developed to improve the recovery efficiency of paclitaxel derived from Taxus chinensis. The polar impurities contained in the sample were effectively removed by washing with water at a sample/water ratio of 1:40 (w/v) for 10 min. In addition, the non-polar impurities were effectively removed by washing with hexane at a sample/hexane ratio of 1:160 (w/v) for 20 min. A high purity of paclitaxel (>30.0%) was obtained in a short operating time (~30 min) by sequential washing with water and hexane.
Keywords
Paclitaxel; Purification; Tandem washing; Water; Hexane; Process optimization;
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Times Cited By KSCI : 1  (Citation Analysis)
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