Browse > Article
http://dx.doi.org/10.9713/kcer.2021.59.4.514

Drug Delivery Study on Chitosan Nanoparticles Using Iron Oxide (II, III) and Valine  

Jang, So-Hyeon (Department of Chemical and Biochemical Engineering, Gachon University)
Kang, Ik-Joong (Department of Chemical and Biochemical Engineering, Gachon University)
Publication Information
Korean Chemical Engineering Research / v.59, no.4, 2021 , pp. 514-520 More about this Journal
Abstract
A drug delivery system (DDS) based on nanoparticles has been used as a mediator to improve the efficacy of a drug by controlling the amount of drug released and delivering it to a target place. Chitosan, which is non-toxic and biodegradable, has good biocompatibility and excellent adsorption, so it can be used as a drug delivery vehicle. Valine, the essential amino acids, helps muscle growth and tissue recovery, and along with other amino acids. It lowers blood sugar levels and increases growth hormone production. In this study, Valine was adsorbed on magnetic chitosan which is capable of drug absorption, and Fe3O4-Valine CNPs was prepared through cross-linking with TPP (Tripolyphosphate). And then absorption and release trends of valine were investigated with the Fe3O4-Valine CNPs. Fe3O4, which has relatively high stability, is used to make the drug carrier magnetic so that the drug can be delivered to a target place. At optimal conditions, the absorption and release tendency of Fe3O4-Valine CNP was confirmed by analyzing by UV-Vis through the Ninhydrin test which is the color reaction of amino acids and by measuring the size of the particles, it was confirmed that it is suitable as a drug carrier.
Keywords
DDS; Valine; $Fe_3O_4$; Chitosan nanoparticles;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Prabaharan, M., "Review Paper: Chitosan Derivatives as Promising Materials for Controlled Drug Delivery," J. Biomater Appl., 23, 5-36(2008).   DOI
2 Lim, J. W. and Kang, I. J., "Fabrication of Chitosan-gold Nanocomposites Combined with Optical Fiber as SERS Substrates to Detect Dopamine Molecules," Bulletin of the Korean Chemical Society, 35, 25-29(2014).   DOI
3 Meguid, M. M., Matthews, D. E., Meredith, C. N., Young, V. R., "Valine Kinetics at Graded Valine Intakes in Young Men," The American Journal of Clinical Nutrition, 43, 781-786(1986).   DOI
4 Kingsley, J. D., Dou, H., Morehead, J., Rabinow, B., Gendelman, H. E. and Destache, C. J., "Nanotechnology: A Focus on Nanoparticles as a Drug Delivery System," Journal of Neuroimmune Pharmacology, 1, 340-350(2006).   DOI
5 Rampino, A., Borgogna, M., Blasi, P., Bellich, B. and Cesaro, A., "Chitosan Nanoparticles: Preparation, Size Evolution and Stability," Pharmaceutical Nanotechnology, 455, 219-228(2013).
6 Farokhzad, O. C. and Langer, R., "Impact of Nanotechnology on Drug Delivery," ACS Nano, 3, 16-20(2009).   DOI
7 Luangtana-anan, M., Nunthanid, J. and Limmatvapirat, S., "Potential of Different Salt Forming Agents on the Formation of Chitosan Nanoparticles as Carriers for Protein Drug Delivery Systems," Journal of Pharmaceutical Investigation, 49, 37-44(2019).   DOI
8 Kalant, H., "Colorimetric Ninhydrin Reaction for Measurement of α-Amino Nitrogen," Anal. Chem, 265-266(1956).   DOI
9 Sun, S. W., Lin, Y. C., Weng, Y. M. and Chen, M. J., "Efficiency Improvements on Ninhydrin Method for Amino Acid Quantification," Journal of Food Composition and Analysis, 19, 112-117 (2006).   DOI
10 Nasti, A., Zaki, N. M., Leonardis, P. D., Ungphaiboon, S., Sansongsak, P., Rimoli, M. G. and Tirelli, N., "Chitosan/TPP and Chitosan/TPP-hyaluronic Acid Nanoparticles: Systematic Optimisation of the Preparative Process and Preliminary Biological Evaluation," Pharmaceutical Research, 26, 1918-1930(2009).   DOI
11 Moore, S., "Amino Acid Analysis: Aqueous Dimethyl Sulfoxide as Solvent for the Ninhydrin Reaction," Journal of Biological Chemistry., 243, 6281-6283(1968).   DOI
12 Ahmed, T. A. and Aljaeid, B. M., "Preparation, Characterization, and Potential Application of Chitosan, Chitosan Derivatives, and Chitosan Metal Nanoparticles in Pharmaceutical Drug Delivery," Drug Des Devel Ther, 10, 483-507(2016).   DOI
13 Journal of Advanced Pharmacy Education & Research 1(4): 201-213 (2011) ISSN 2249-3379 201 Yadav A., Ghune M., Jain D. K., "Nano-medicine Based Drug Delivery System," Journal of Advanced Pharmacy Education & Research, 1, 201-213(2011).
14 Singh, R. and Lillard, J. W., "Nanoparticle-based Targeted Drug Delivery," Exp Mol Pathol, 86, 215-223(2009).   DOI
15 Hirano, S., Seino, H., Akiyama, Y. and Nonaka, I., "Chitosan: A Biocompatible Material for Oral and Intravenous Administrations," Progress in Biomedical Polymers, 283-290(1990).
16 Li, G. Y., Jiang, Y. R., Huang, K. L., Ding, P. D. and Chen, J., "Preparation and Properties of Magnetic Fe3O4-Chitosan Nanoparticles," Journal of Alloys and Compounds, 466, 451-456(2008).   DOI
17 Arum, Y., Oh, Y. O., Kang, H. W., Ahn, S. H. and Oh, J. H., "Chitosan-Coated Fe3O4 Magnetic Nanopar-ticles as Carrier of Cisplatin for Drug Delivery," Fisheries and Aquatic Sciences, 18, 89-98(2015).   DOI
18 Galhoum, A. A., Mahfouz, M. G., Atia, A. A., Abdel-Rehem, S. T., Gomaa, N. A., Vincent, T. and Guibal, E., "Amino Acid Functionalized Chitosan Magnetic Nanobased Particles for Uranyl Sorption," Ind. Eng. Chem. Res, 54, 12374-12385(2015).   DOI
19 Ko, J. A., Park, H. J., Hwang, S. J., Park, J. B. and Lee, J. S., "Preparation and Characterization of Chitosan Microparticles Intended for Controlled Drug Delivery," International Journal of Pharmaceutics, 249, 165-174(2002).   DOI
20 Sreekumar, S., Goycoolea, F. M., Moerschbacher, B. M. and Rivera-Rodriguez, G. R., "Parameters Influencing the Size of Chitosan-TPP Nano- and Microparticles," Scientific Reports, 8, 4695 (2018).   DOI
21 Lim, J. W. and Kang, I. J., "Fabrication of Chitosan-Gold Nanoshells for γ-Aminobutyric Acid Detection as a Surface-enhanced Raman Scattering Substrate," Bulletin of the Korean Chemical Society, 36, 672-677(2015).   DOI