Browse > Article
http://dx.doi.org/10.9713/kcer.2021.59.3.429

Fabrication and Characterization of Dissolving Microneedles Containing Lecithin for Transdermal Drug Delivery  

Choi, Won-Ho (Department of Chemical Engineering, Hongik University)
Kim, Bumsang (Department of Chemical Engineering, Hongik University)
Publication Information
Korean Chemical Engineering Research / v.59, no.3, 2021 , pp. 429-434 More about this Journal
Abstract
The feasibility of lecithin as a material for dissolving microneedles to improve skin permeability of drugs and the effect of the composition of lecithin on the mechanical strength, solubility, and skin permeability of rhodamine B (RhB) of the dissolving microneedles were investigated. Dissolving microneedles with needles of uniform shape and size were fabricated with the mold made using the laser-writing technique, simpler and more efficient method compared to the photolithography method, the conventional method to fabricate the microneedle mold. The composition of lecithin in the microneedle affected the mechanical strength and solubility of the needle thus, the mechanical strength of the needle increased as the composition of lecithin in the needle increased, resulting in improving the skin permeability of RhB contained in the microneedles. When comparing the microneedles containing same composition of amylopectin (AP), the skin permeability of RhB of the microneedles containing lecithin was higher. These results indicate that lecithin can be used as a material for dissolving microneedles and the skin permeability of the microneedle could be controlled by changing the composition of lecithin.
Keywords
Lecithin; Dissolving microneedles; Microneedle composition; Skin permeability; Transdermal drug delivery;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Van der Maaden, K., Jiskoot, W. and Bouwstra, J., "Microneedle Technologies for (trans)dermal Drug and Vaccine Delivery," J. Control. Rel., 161, 645-655(2012).   DOI
2 Kim, J. D., Kim, M., Yang, H., Lee, K. and Jung, H., "Droplet-born Air Blowing: Novel Dissolving Microneedle Fabrication," J. Control. Rel., 170, 430-436(2013).   DOI
3 Monkare, J., Nejadnik, M. R., Baccouche, K., Romeijn, S., Jiskoot, W. and Bouwstra, J. A., "IgG-loaded Hyaluronan-based Dissolving Microneedles for Intradermal Protein Delivery," J. Control. Rel., 218, 53-62(2015).   DOI
4 Bentley, M. V. L. B., Kedor, E. R. M., Vianna, R. M. and Collett, J. H., "The Influence of Lecithin and Urea on the in vitro Permeation of Hydrocortisone Acetate Through Skin from Hairless Mouse," Int. J. Pharm., 146, 255-262(1997).   DOI
5 Lee, S. H., Lee, H. H. and Choi, S. S., "Nanoparticle Popsicle: Transdermal Delivery of Nanoparticles Using Polymeric Microneedle Array," Korean J. Chem. Eng., 28, 1913-1917(2011).   DOI
6 Park, J. H., Allen, M. G. and Prausnitz, M. R., "Biodegradable Polymer Microneedles: Fabrication, Mechanics and Transdermal Drug Delivery," J. Control Rel., 104, 51-66(2005).   DOI
7 Feng, X. H., Pelton, R. and Leduc, M., "Mechanical Properties of Polyelectrolyte Complex Films Based on Polyvinylamine and Carboxymethyl Cellulose," Ind. Eng. Chem. Res., 45, 6665-6671 (2006).   DOI
8 Prausnitz, M. R., "Microneedles for Transdermal Drug Delivery," Adv. Drug Deliv. Rev., 56, 581-587(2004).   DOI
9 Sunkavalli, S., Eedara, B. B., Janga, K. Y., Velpula, A., Jukanti, R. and Bandari, S., "Preparation and Characterization of Docetaxel Self-nanoemulsifying Powders (SNEPs): A Strategy for Improved Oral Delivery," Korean J. Chem. Eng., 33, 1115-1124(2016).   DOI
10 Yang, J. H. and Kim, B., "Synthesis and Characterization of Ethosomal Carriers Containing Cosmetic Ingredients for Enhanced Transdermal Delivery of Cosmetic Ingredients," Korean J. Chem. Eng., 35, 792-797(2018).   DOI
11 Lee, J. W., Park, J. H. and Prausnitz, M. R., "Dissolving Microneedles for Transdermal Drug Delivery," Biomater., 29, 2113-2124 (2008).   DOI
12 Liu, S., Jin, M. N., Quan, Y. S., Kamiyama, F., Kusamori, K., Katsumi, H. and Yamamoto, A., "Transdermal Delivery of Relatively High Molecular Weight Drugs Using Novel Self-dissolving Microneedle Arrays Fabricated from Hyaluronic Acid and Their Characteristics and Safety After Application to the Skin," Eur. J. Pharm., 86, 267-276(2014).
13 Zhu, Z., Luo, H., Lu, W., Laun, H., Wu, Y., Luo, J., Wang, Y., Pi, J., Lim, C. Y. and Wang, H., "Rapidly Dissolvable Microneedle Patches for Transdermal Delivery of Exenatide," Pharm Res., 31, 3348-3360(2014).   DOI
14 Mahjour, M., Mauser, B., Rashidbaigi, Z. and Fawzi, M. B., "Effect of Egg Yolk Lecithins and Commercial Soybean Lecithins on in vitro Skin Permeation of Drugs," J. Control. Rel., 14, 243-252(1990).   DOI
15 Hong, X., Wu, Z., Chen, L., Wu, F., Wei, L. and Yuan, W., "Hydrogel Microneedle Arrays for Transdermal Drug Delivery," NanoMicro. Lett., 6, 191-199(2014).
16 Jung, S. M., Kim, H. J., Kim, B. J., Joo, G. S., Yoon, T. S., Kim, Y. S. and Lee, H. H., "Amperometric Detection of Bisphenol-A on Laser Fabricated Capillary Electrophoresis Device," BioChip. J., 3, 219-223(2009).
17 Kim, Y. C., Park, J.-H. and Prausnitz, M. R., "Microneedles for Drug and Vaccine Delivery," Adv. Drug Deliv. Rev., 64, 1547-1568(2012).   DOI
18 Giudice, E. L. and Campbell, J. D., "Needle-free Vaccine Delivery," Adv. Drug Deliv. Rev, 58, 68-89(2006).   DOI
19 Ito, Y., Yoshimura, M., Tanaka, T. and Takada, K., "Effect of Lipophilicity on the Bioavailability of dRugs After Percutaneous Administration by Dissolving Microneedles," J. Pharm. Sci., 101, 1145-1156(2012).   DOI