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http://dx.doi.org/10.9713/kcer.2020.58.4.530

Synthesis of Ceramide Nanoemulsion by High-Pressure Homogenizer and Evaluation of Its Stability  

Hidajat, Marcel Jonathan (Research and Development Department, Hiflux Co. Ltd.)
Noh, Jongho (Research and Development Department, Ilshin Autoclave Co. Ltd.)
Park, Jongbeom (Research and Development Department, Ilshin Autoclave Co. Ltd.)
Hong, Jaehwa (Department of Skincare Research Center, Kolmar Korea Co. Ltd.)
Kim, Hyeonhyo (Research and Development Department, Ilshin Autoclave Co. Ltd.)
Jo, Wantaek (Research and Development Department, Ilshin Autoclave Co. Ltd.)
Publication Information
Korean Chemical Engineering Research / v.58, no.4, 2020 , pp. 530-535 More about this Journal
Abstract
A ceramide-containing nanoemulsion was synthesized by using a High-Pressure Homogenizer (HPH) to observe its changes in properties and long-term stability. The droplet size, droplet distribution and zeta potential of nanoemulsion were examined by varying the pressure and the number of passes of the HPH. The increase in HPH pressure and number of passes decreased the average droplet size and made the nanoemulsion more uniform. However, beyond certain operating condition, the recombination between the droplets was confirmed due to droplet surface energy and emulsifier. This study also shows that the decrease in droplet size increased the nanoemulsion viscosity although only minimal changes occurred in the zeta potential. The formed nanoemulsion was then tested for its stability by storing it at 25 and 45 ℃ for 28 days. During the first week, the average droplet size increased due to recombination and then subsequently remained constant. We confirmed that ceramide nanoemulsion for industrial application could be synthesized by using HPH.
Keywords
High-pressure homogenizer; Nanoemulsion; Stability; Ceramide; Recombination;
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Times Cited By KSCI : 4  (Citation Analysis)
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1 Kwon, S. S., Kong, B. J., Cho, W. G. and Park, S. N., "Formation of Stable Hydrocarbon Oil-in-water Nanoemulsions by Phase Inversion Composition Method at Elevated Temperature," Korean J. Chem. Eng., 32(3), 540-546(2015).   DOI
2 Forgiarini, A., Esquena, J., Gonzalez, C. and Solans, C., "Formation of Nano-emulsions by Low-energy Emulsification Methods at Constant Temperature," Langmuir, 17(7), 2076-2083(2001).   DOI
3 Sonneville-Aubrun, O., Babayan, D., Bordeaux, D., Lindner, P., Rata, G. and Cabane, B., "Phase Transition Pathways for the Production of 100 nm Oil-in-water Emulsions," Phys. Chem. Chem. Phys., 11(1), 101-110(2009).   DOI
4 Delmas, T., Piraux, H., Couffin, A.-C., Texier, I., Vinet, F., Poulin, P., Cates, M. E. and Bibette, J., "How to Prepare and Stabilize Very Small Nanoemulsions," Langmuir, 27(5), 1683-1692(2011).   DOI
5 You, K. M., Jang, H. H., Lee, E. S., Park, J. T. and Hong, S. T., "Study of Stability and Shelf-life of Red Ginseng Beverage Emulsified by Homogenizer High Pressure," Journal of Oil & Applied Science, 35(1), 70-79(2018).   DOI
6 Jo, Y. J., Lee, S. B., Lee, J. K. and Kwon, Y. J., "Preparation of Nanoemulsions Containing Curcumin by High Pressure Homogenization," Food Eng. Prog., 18(4), 341-347(2014).   DOI
7 Cho, J. H., Kim, T. Y., Yun, H. Y. and Kim, H. H., "Facile Depolymerization Process of ${\beta}$-glucan Through the Use of a High Pressure Homogenizer," Am. J. Res. Commun., 2(4), 168-178(2014).
8 Traul, K. A., Driedger, A., Ingle, D. L. and Nakhasi, D., "Review of the Toxicologic Properties of Medium-chain Triglycerides," Food Chem. Toxicol., 38(1), 79-98(2000).   DOI
9 Jafari, S. M., Assadpoor, E., He, Y. and Bhandari, B., "Re-coalescence of Emulsion Droplets During High-energy Emulsification," Food Hydrocolloids, 22(7), 1191-1202(2008).   DOI
10 Stickel, J. J. and Powell, R. L., "Fluid Mechanics and Rheology of Dense Suspensions," Annu. Rev. Fluid Mech., 37(1), 129-149 (2005).   DOI
11 Nguyen, C. T., Desgranges, F., Roy, G., Galanis, N., Mare, T., Boucher, S. and Angue Mintsa, H., "Temperature and Particle-size Dependent Viscosity Data for Water-based Nanofluids - Hysteresis Phenomenon," Int. J. Heat Fluid Flow, 28(6), 1492-1506(2007).   DOI
12 Jia-Fei, Z., Zhong-Yang, L., Ming-Jiang, N. and Ke-Fa, C., "Dependence of Nanofluid Viscosity on Particle Size and pH value," Chin. Phys. Lett., 26(6), 066202(2009).   DOI
13 Ee, S. L., Duan, X., Liew, J. and Nguyen, Q. D., "Droplet size and Stability of Nano-emulsions Produced by the Temperature Phase Inversion Method," Chem. Eng. J., 140(1), 626-631(2008).   DOI
14 Elias, P. M., "Epidermal Lipids, Membranes, and Keratinization," Int. J. Dermatol., 20(1), 1-19(1981).   DOI
15 Solans, C., Izquierdo, P., Nolla, J., Azemar, N. and Garcia-Celma, M. J., "Nano-emulsions," Curr. Opin. Colloid Interface Sci., 10(3), 102-110(2005).   DOI
16 Park, B. D., Uhm, J. G., Lee, M. J. and Kim, Y., "The Preparation of Multi-lamellar Emulsion which Containing Pseudoceramide( PC-9)," J. Soc. Cosmet. Sci. Korea, 25(1), 55-68(1999).
17 Hatziantoniou, S., Deli, G., Nikas, Y., Demetzos, C. and Papaioannou, G. T., "Scanning Electron Microscopy Study on Nanoemulsions and Solid Lipid Nanoparticles Containing High Amounts of Ceramides," Micron, 38(8), 819-823(2007).   DOI
18 Su, R., Yang, L., Wang, Y., Yu, S., Guo, Y., Deng, J., Zhao, Q. and Jin, X., "Formulation, Development, and Optimization of a Novel Octyldodecanol-based Nanoemulsion for Transdermal Delivery of Ceramide IIIB," Int. J. Nanomed., 12, 5203-5221(2017).   DOI
19 Yilmaz, E. and Borchert, H.-H., "Effect of Lipid-containing, Positively Charged Nanoemulsions on Skin Hydration, Elasticity and Erythema-An in vivo Study," Int. J. Pharm., 307(2), 232-238(2006).   DOI
20 Cho, W. G., Kim, K. A., Jang, S. I. and Cho, B. O., "Behaviour of Nanoemulsions Containing Ceramide IIIB and Stratum Corneum Lipids," J. Soc. Cosmet. Sci. Korea, 44(1), 31-37(2018).   DOI
21 Sekiguchi, A., Yamauchi, H., Manosroi, A., Manosroi, J. and Abe, M., "Molecular Interactions Between Phospholipids and Glycolipids in a Lipid Bilayer," Colloids Surf., B, 4(5), 287-296(1995).   DOI
22 Golemanov, K., Tcholakova, S., Denkov, N. D. and Gurkov, T., "Selection of Surfactants for Stable Paraffin-in-water Dispersions, Undergoing Solid-liquid Transition of the Dispersed Particles," Langmuir, 22(8), 3560-3569(2006).   DOI
23 Sonneville-Aubrun, O., Simonnet, J. T. and L'Alloret, F., "Nanoemulsions: a New Vehicle for Skincare Products," Adv. Colloid Interface Sci., 108-109, 145-149(2004).   DOI
24 Sonneville-Aubrun, O., Yukuyama, M. N. and Pizzino, A. In S. M. Jafari, and D. J. McClements (Ed.), Nanoemulsions, London, UK. 435-475(2018).
25 Gupta, A., Eral, H. B., Hatton, T. A. and Doyle, P. S., "Nanoemulsions: Formation, Properties and Applications," Soft Matter, 12(11), 2826-2841(2016).   DOI
26 Morales, D., Gutierrez, J. M., García-Celma, M. J. and Solans, Y. C., "A Study of the Relation Between Bicontinuous Microemulsions and Oil/water Nano-emulsion Formation," Langmuir, 19(18), 7196-7200(2003).   DOI
27 Izquierdo, P., Esquena, J., Tadros, T. F., Dederen, J. C., Feng, J., Garcia-Celma, M. J., Azemar, N. and Solans, C., "Phase behavior and Nano-emulsion Formation by the Phase Inversion Temperature Method," Langmuir, 20(16), 6594-6598(2004).   DOI