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http://dx.doi.org/10.9713/kcer.2020.58.4.499

Electrochemical Biosensors based on Nanocomposites of Carbon-based Dots  

Ngo, Yen-Linh Thi (School of Chemical Engineering, University of Ulsan)
Jana, Jayasmita (School of Chemical Engineering, University of Ulsan)
Chung, Jin Suk (School of Chemical Engineering, University of Ulsan)
Hur, Seung Hyun (School of Chemical Engineering, University of Ulsan)
Publication Information
Korean Chemical Engineering Research / v.58, no.4, 2020 , pp. 499-513 More about this Journal
Abstract
Among the many studies of carbon-based nanomaterials, carbon-based dots (CDs) have attracted considerable interest owing to their large surface area, intrinsic low-toxicity, excellent biocompatibility, high solubility, and low-cost with environmentally friendly routes, as well as their ability for modification with other nanomaterials. CDs have several applications in biosensing, photocatalysis, bioimaging, and nanomedicine. In addition, the fascinating electrochemical properties of CDs, including high active surface area, excellent electrical conductivity, electrocatalytic activity, high porosity, and adsorption capability, make them potential candidates for electrochemical sensing materials. This paper reviews the recent developments and synthesis of CDs and their composites for the proposed electrochemical sensing platforms. The electrochemical principles and future perspective and challenges of electrochemical biosensors are also discussed based on CDs-nanocomposites.
Keywords
Carbon dots; Graphene quantum dots; Nanocomposite; Electrochemical; Biosensor;
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1 Zhang, S., Li, R., Liu, X., Yang, L., Lu, Q. and Liu, M., "A Novel Multiple Signal Amplifying Immunosensor Based on the Strategy of in Situ-produced Electroactive Substance by ALP and Carbon-based Ag-Au Bimetallic as the Catalyst and Signal Enhancer," Biosens. Bioelectron., 92, 457-464(2017).   DOI
2 Ponnaiah, S. K., Prakash, P., Vellaichamy, B., Paulmony, T. and Selvanathan, R., "Picomolar-level Electrochemical Detection of Thiocyanate in the Saliva Samples of Smokers and Non-smokers of Tobacco Using Carbon Dots Doped $Fe_3O_4$ Nanocomposite Embedded on g-$C_3N_4$ Nanosheets," Electrochim. Acta, 283, 914-921(2018).   DOI
3 Cai, J., Sun, B., Gou, X., Gou, Y., Li, W. and Hu, F., "A Novel Way for Analysis of Calycosin via Polyaniline Functionalized Graphene Quantum Dots Fabricated Electrochemical Sensor," J. ElectroAnal. Chem., 816, 123-131(2018).   DOI
4 Hatamluyi, B., Es'haghi, Z., Modarres Zahed, F., Darroudi, M., "A Novel Electrochemical Sensor Based on GQDs-PANI/ZnONCs Modified Glassy Carbon Electrode for Simultaneous Determination of Irinotecan and 5-Fluorouracil in Biological Samples," Sens. Actuators B Chem., 286, 540-549(2019).   DOI
5 Khodadadi, A., Faghih-Mirzaei, E., Karimi-Maleh, H., Abbaspourrad, A., Agarwal, S. and Gupta, V. K., "A New Epirubicin Biosensor Based on Amplifying DNA Interactions with Polypyrrole and Nitrogen-doped Reduced Graphene: Experimental and Docking Theoretical Investigations," Sens. Actuators B Chem., 284, 568-574(2019).   DOI
6 Tian, P., Tang, L., Teng, K. S. and Lau, S. P., "Graphene Quantum Dots from Chemistry to Applications," Mater. Today Chem., 10, 221-258(2018).   DOI
7 Tang, L., Ji, R., Cao, X., Lin, J., Jiang, H., Li, X., "Deep Ultraviolet Photoluminescence of Water-Soluble Self-Passivated Graphene Quantum Dots," ACS Nano, 6, 5102-5110(2012).   DOI
8 Sagbas, S. and Sahiner, N., in A. Khan, M. Jawaid, Inamuddin, A. M. Asiri (Eds.), Nanocarbon and its Composites, Woodhead Publishing, 651-676(2019).
9 De, B. and Karak, N., "Recent Progress in Carbon Dot-metal Based Nanohybrids for Photochemical and Electrochemical Applications," J. Mater. Chem. A, 5, 1826-1859(2017).   DOI
10 Han, M., Zhu, S., Lu, S., Song, Y., Feng, T. and Tao, S., "Recent Progress on the Photocatalysis of Carbon Dots: Classification, Mechanism and Applications," Nano Today, 19, 201-218(2018).   DOI
11 Guo, X., Zhang, H., Sun, H., Tade, M. O. and Wang, S., "Green Synthesis of Carbon Quantum Dots for Sensitized Solar Cells," ChemPhotoChem, 1, 116-119(2017).   DOI
12 Cho, M.-J. and Park, S.-Y., "Carbon-dot-based Ratiometric Fluorescence Glucose Biosensor," Sens. Actuators B Chem., 282, 719-729(2019).   DOI
13 Hu, C., Li, M., Qiu, J. and Sun, Y.-P., "Design and Fabrication of Carbon Dots for Energy Conversion and Storage," Chem. Soc. Rev., 48, 2315-2337(2019).   DOI
14 Kasouni, A., Chatzimitakos, T. and Stalikas, C., "Bioimaging Applications of Carbon Nanodots: A Review," C, 5, 19(2019).
15 Li, Y., Zhong, Y., Zhang, Y., Weng, W. and Li, S., "Carbon Quantum Dots/octahedral $Cu_2O$ Nanocomposites for Non-enzymatic Glucose and Hydrogen Peroxide Amperometric Sensor," Sens. Actuators B Chem., 206, 735-743(2015).   DOI
16 Rao, H., Zhao, X., Liu, X., Zhong, J., Zhang, Z. and Zou, P., "A Novel Molecularly Imprinted Electrochemical Sensor Based on Graphene Quantum Dots Coated on Hollow Nickel Nanospheres with High Sensitivity and Selectivity for the Rapid Determination of Bisphenol S," Biosens. Bioelectron., 100, 341-347(2018).   DOI
17 Cui, M., Huang, J., Wang, Y., Wu, Y. and Luo, X., "Molecularly Imprinted Electrochemical Sensor for Propyl Gallate Based on PtAu Bimetallic Nanoparticles Modified Graphene-carbon Nanotube Composites," Biosens. Bioelectron., 68, 563-569(2015).   DOI
18 Shervedani, R. K., Karevan, M. and Amini, A., "Prickly Nickel Nanowires Grown on Cu Substrate as a Supersensitive Enzymefree Electrochemical Glucose Sensor," Sens. Actuators B Chem., 204, 783-790(2014).   DOI
19 Atar, N., Yola, M. L. and Eren, T., "Sensitive Determination of Citrinin Based on Molecular Imprinted Electrochemical Sensor," Appl. Surf. Sci., 362, 315-322(2016).   DOI
20 Huang, Q., Lin, X., Zhu, J.-J. and Tong, Q.-X., "Pd-Au@carbon Dots Nanocomposite: Facile Synthesis and Application as An Ultrasensitive Electrochemical Biosensor for Determination of Colitoxin DNA in Human Serum," Biosens. Bioelectron., 94, 507-512(2017).   DOI
21 Xu, G., Han, J., Ding, B., Nie, P., Pan, J., Dou, H., "Biomass-derived Porous Carbon Materials with Sulfur and Nitrogen Dual-doping for Energy Storage," Green Chem., 17, 1668-1674 (2015).   DOI
22 Kim, J., Park, J., Kim, H., Singha, K. and Kim, W. J., "Transfection and Intracellular Trafficking Properties of Carbon Dot-gold Nanoparticle Molecular Assembly Conjugated with PEI-pDNA," Biomaterials, 34, 7168-7180(2013).   DOI
23 Sun, H., Wu, L., Wei, W. and Qu, X., "Recent Advances in Graphene Quantum Dots for Sensing," Mater. Today, 16, 433-442 (2013).   DOI
24 Tuteja, S. K., Chen, R., Kukkar, M., Song, C. K., Mutreja, R. and Singh, S., "A Label-free Electrochemical Immunosensor for the Detection of Cardiac Marker Using Graphene Quantum Dots (GQDs)," Biosens. Bioelectron., 86, 548-556(2016).   DOI
25 Guo, Q., Zhang, M., Zhou, G., Zhu, L., Feng, Y. and Wang, H., "Highly Sensitive Simultaneous Electrochemical Detection of Hydroquinone and Catechol with Three-dimensional N-doping Carbon Nanotube Film Electrode," J. ElectroAnal. Chem., 760, 15-23(2016).   DOI
26 Campuzano, S., Yanez-Sedeno, P. and Pingarron, J. M., "Carbon Dots and Graphene Quantum Dots in Electrochemical Biosensing," Nanomaterials, 9, 634(2019).   DOI
27 Zhou, Q., Lin, Y., Lin, Y., Wei, Q., Chen, G. and Tang, D., "Highly Sensitive Electrochemical Sensing Platform for Lead Ion Based on Synergetic Catalysis of DNAzyme and Au-Pd Porous Bimetallic Nanostructures," Biosens. Bioelectron., 78, 236-243(2016).   DOI
28 He, Q., Tian, Y., Wu, Y., Liu, J., Li, G. and Deng, P., "Electrochemical Sensor for Rapid and Sensitive Detection of Tryptophan by a Cu(2)O Nanoparticles-Coated Reduced Graphene Oxide Nanocomposite," Biomolecules, 9, 176(2019).   DOI
29 Mollarasouli, F., Asadpour-Zeynali, K., Campuzano, S., Yanez-Sedeno, P. and Pingarron, J. M., "Non-enzymatic Hydrogen Peroxide Sensor Based on Graphene Quantum Dots-chitosan/methylene Blue Hybrid Nanostructures," Electrochim. Acta, 246, 303-314(2017).   DOI
30 Asadian, E., Ghalkhani, M., and Shahrokhian, S., "Electrochemical Sensing Based on Carbon Nanoparticles: A Review," Sens. Actuators B Chem., 293, 183-209(2019).   DOI
31 Cayuela, A., Soriano, M. L., Carrillo-Carrion, C., Valcarcel, M., "Semiconductor and Carbon-based Fluorescent Nanodots: the Need for Consistency," Chem. Commun., 52, 1311-1326(2016).   DOI
32 Sciortino, A., Cannizzo, A. and Messina, F., "Carbon Nanodots: A Review-From the Current Understanding of the Fundamental Photophysics to the Full Control of the Optical Response," C, 4, 67(2018).   DOI
33 Zheng, X. T., Ananthanarayanan, A., Luo, K. Q. and Chen, P., "Glowing Graphene Quantum Dots and Carbon Dots: Properties, Syntheses, and Biological Applications," Small, 11, 1620-1636(2015).   DOI
34 Le, T. H., Lee, D. H., Kim, J. H., Park, S. J., "Synthesis of Enhanced Fluorescent Graphene Quantum Dots for Catecholamine Neurotransmitter Sensing," Korean J. Chem. Eng., 37, 1000-1007(2020).   DOI
35 Liu, L., Anwar, S., Ding, H., Xu, M., Yin, Q. and Xiao, Y., "Electrochemical Sensor Based on F,N-doped Carbon Dots Decorated Laccase for Detection of Catechol," J. ElectroAnal. Chem., 840, 84-92(2019).   DOI
36 Zhang, L., Han, Y., Zhu, J., Zhai, Y. and Dong, S., "Simple and Sensitive Fluorescent and Electrochemical Trinitrotoluene Sensors Based on Aqueous Carbon Dots," Anal. Chem., 87, 2033-2036(2015).   DOI
37 Jiang, Y., Wang, B., Meng, F., Cheng, Y. and Zhu, C., "Microwave-assisted Preparation of N-doped Carbon Dots as a Biosensor for Electrochemical Dopamine Detection," J. Colloid Interface Sci., 452, 199-202(2015).   DOI
38 Fu, L., Wang, A., Lai, G., Lin, C.-T., Yu, J. and Yu, A., "A Glassy Carbon Electrode Modified with N-doped Carbon Dots for Improved Detection of Hydrogen Peroxide and Paracetamol," Microchim. Acta, 185, 87(2018).   DOI
39 Xie, R., Wang, Z., Zhou, W., Liu, Y., Fan, L. and Li, Y., "Graphene Quantum Dots as Smart Probes for Biosensing," Anal. Methods, 8, 4001-4016(2016).   DOI
40 Xu, X., Ray, R., Gu, Y., Ploehn, H. J., Gearheart, L., Raker, K., et al., "Electrophoretic Analysis and Purification of Fluorescent Single-Walled Carbon Nanotube Fragments," J. Am. Chem. Soc., 126, 12736-12737(2004).   DOI
41 Shiri, S., Pajouheshpoor, N., Khoshsafar, H., Amidi, S. and Bagheri, H., "An Electrochemical Sensor for the Simultaneous Determination of Rifampicin and Isoniazid Using a C-dots@$CuFe_2O_4$ Nanocomposite Modified Carbon Paste Electrode," New J. Chem., 41, 15564-15573(2017).   DOI
42 Zhou, M., Guo, J., Guo, L.-P. and Bai, J., "Electrochemical Sensing Platform Based on the Highly Ordered Mesoporous Carbon-Fullerene System," Anal. Chem., 80, 4642-4650(2008).   DOI
43 Banks, C. E., Davies, T. J. Wildgoose, G. G. and Compton, R. G., "Electrocatalysis at Graphite and Carbon Nanotube Modified Electrodes: Edge-plane Sites and Tube Ends are the Reactive Sites," Chem. Commun., 37(7), 829-841(2005).
44 Hu, S., Huang, Q., Lin, Y., Wei, C., Zhang, H. and Zhang, W., "Reduced Graphene Oxide-carbon Dots Composite as An Enhanced Material for Electrochemical Determination of Dopamine," Electrochim. Acta, 130, 805-809(2014).   DOI
45 Hasanzadeh, M., Karimzadeh, A., Shadjou, N., Mokhtarzadeh, A., Bageri, L., and Sadeghi, S., "Graphene Quantum Dots Decorated with Magnetic Nanoparticles: Synthesis, Electrodeposition, Characterization and Application as An Electrochemical Sensor Towards Determination of Some Amino Acids at Physiological pH," Mater. Sci. Eng. C, 68, 814-830(2016).   DOI
46 Abbas, M. W., Soomro, R. A., Kalwar, N. H., Zahoor, M., Avci, A. and Pehlivan, E., "Carbon Quantum Dot Coated $Fe_3O_4$ Hybrid Composites for Sensitive Electrochemical Detection of Uric Acid," Microchem. J., 146, 517-524(2019).   DOI
47 Wei, C., Huang, Q., Hu, S., Zhang, H., Zhang, W. and Wang, Z., "Simultaneous Electrochemical Determination of Hydroquinone, Catechol and Resorcinol at Nafion/multi-walled Nanotubes/carbon Dots/multi-walled Nanotubes Modified Glassy Electrode," Electrochim. Acta, 149, 237-244(2014).   DOI
48 Ngo, Y.-L.T. and Hur, S. H., "Low-temperature $NO_2$ Gas Sensor Fabricated with NiO and Reduced Graphene Oxide Hybrid Structure," Mater. Res. Bull., 84, 168-176(2016).   DOI
49 Bai, J., Sun, C. and Jiang, X., "Carbon Dots-decorated Multiwalled Carbon Nanotubes Nanocomposites as a High-performance Electrochemical Sensor for Detection of $H_2O_2$ in Living Cells," Anal. Bioanal.Chem., 408, 4705-4714(2016).   DOI
50 Zhang, W., Zheng, J., Lin, Z., Zhong, L., Shi, J. and Wei, C., "Highly Sensitive Simultaneous Electrochemical Determination of Hydroquinone, Catechol and Resorcinol Based on Carbon Dot/reduced Graphene Oxide Composite Modified Electrodes," Anal. Methods, 7, 6089-6094(2015).   DOI
51 Huang, Q., Lin, X., Tong, L. and Tong, Q.-X., "Graphene Quantum Dots/Multiwalled Carbon Nanotubes Composite-Based Electrochemical Sensor for Detecting Dopamine Release from Living Cells," ACS Sustain. Chem. Eng., 8, 1644-1650(2020).   DOI
52 Samuei, S., Fakkar, J., Rezvani, Z., Shomali, A. and Habibi, B., "Synthesis and Characterization of Graphene Quantum Dots/CoNiAl-layered Double-hydroxide Nanocomposite: Application as a Glucose Sensor," Anal. Biochem., 521, 31-39(2017).   DOI
53 Mallakpour, S. and Khadem, E., in V. K. Thakur, M. K. Thakur, R. K. Gupta (Eds.), Hybrid Polymer Composite Materials, Woodhead Publishing, 235-261(2017).
54 Shan, D., Cosnier, S., and Mousty, C., "Layered Double Hydroxides: An Attractive Material for Electrochemical Biosensor Design," Anal. Chem., 75, 3872-3879(2003).   DOI
55 Wang, Y., Wang, Z., Rui, Y. and Li, M., "Horseradish Peroxidase Immobilization on Carbon Carbon, Nanodots/CoFe Layered Double Hydroxides: Direct Electrochemistry and Hydrogen Peroxide Sensing," Biosens. Bioelectron., 64, 57-62(2015).   DOI
56 Jiang, Y., Li, Y., Li, Y. and Li, S., "A Sensitive Enzyme-free Hydrogen Peroxide Sensor Based on a Chitosan-graphene Quantum Dot/silver Nanocube Nanocomposite Modified Electrode," Anal. Methods, 8, 2448-2455(2016).   DOI
57 Zhuo, S., Shao, M. and Lee, S.-T., "Upconversion and Downconversion Fluorescent Graphene Quantum Dots: Ultrasonic Preparation and Photocatalysis," ACS Nano, 6, 1059-1064(2012).   DOI
58 Pan, D., Zhang, J., Li, Z. and Wu, M., "Hydrothermal Route for Cutting Graphene Sheets into Blue-Luminescent Graphene Quantum Dots," Adv. Mater., 22, 734-738(2010).   DOI
59 Li, H., He, X., Kang, Z., Huang, H., Liu, Y. and Liu, J., "Water-Soluble Fluorescent Carbon Quantum Dots and Photocatalyst Design," Angew. Chem. Int. Ed, 49, 4430-4434(2010).   DOI
60 Peng, J., Gao, W., Gupta, B. K., Liu, Z., Romero-Aburto, R. and Ge, L., "Graphene Quantum Dots Derived from Carbon Fibers," Nano Lett., 12, 844-849(2012).   DOI
61 Li, L.-L., Ji, J., Fei, R., Wang, C.-Z., Lu, Q. and Zhang, J.-R., "A Facile Microwave Avenue to Electrochemiluminescent Two-Color Graphene Quantum Dots," Adv. Funct. Mater., 22, 2971-2979(2012).   DOI
62 Liu, S., Tian, J., Wang, L., Zhang, Y., Qin, X. and Luo, Y., "Hydrothermal Treatment of Grass: A Low-Cost, Green Route to Nitrogen-Doped, Carbon-Rich, Photoluminescent Polymer Nanodots as an Effective Fluorescent Sensing Platform for Label-Free Detection of Cu(II) Ions," Adv. Mater., 24, 2037-2041(2012).   DOI
63 Liu, F., Jang, M.-H., Ha, H. D., Kim, J.-H., Cho, Y.-H., Seo, T. S., "Facile Synthetic Method for Pristine Graphene Quantum Dots and Graphene Oxide Quantum Dots: Origin of Blue and Green Luminescence," Adv. Mater., 25, 3657-3662(2013).   DOI
64 Dong, Y., Shao, J., Chen, C., Li, H., Wang, R. and Chi, Y., "Blue Luminescent Graphene Quantum Dots and Graphene Oxide Prepared by Tuning the Carbonization Degree of Citric Acid," Carbon, 50, 4738-4743(2012).   DOI
65 Tao, S., Song, Y., Zhu, S., Shao, J., Yang, B., "A New Type of Polymer Carbon Dots with High Quantum Yield: From Synthesis to Investigation on Fluorescence Mechanism," Polymer, 116, 472-478(2017).   DOI
66 Ji, H., Zhou, F., Gu, J., Shu, C., Xi, K. and Jia, X., "Nitrogen-Doped Carbon Dots as A New Substrate for Sensitive Glucose Determination," Sensors, 16, 630(2016).   DOI
67 Li, L., Liu, D., Wang, K., Mao, H. and You, T., "Quantitative Detection of Nitrite with N-doped Graphene Quantum Dots Decorated N-doped Carbon Carbon, Nanofibers Composite-based Electrochemical Sensor," Sens. Actuators B Chem., 252, 17-23(2017).   DOI
68 Roushani, M. and Abdi, Z., "Novel Electrochemical Sensor Based on Graphene Quantum Dots/riboflavin Nanocomposite for the Detection of Persulfate," Sens. Actuators B Chem., 201, 503-510 (2014).   DOI
69 Roushani, M. and Sarabaegi, M., "Novel Electrochemical Sensor Based on Carbon Nanodots/chitosan Nanocomposite for the Detection of Tryptophan," J. Iran. Chem. Soc., 12, 1875-1882(2015).   DOI
70 Yu, L., Yue, X., Yang, R., Jing, S. and Qu, L., "A Sensitive and Low Toxicity Electrochemical Sensor for 2,4-dichlorophenol Based on the Nanocomposite of Carbon Dots, Hexadecyltrimethyl Ammonium Bromide and Chitosan," Sens. Actuators B Chem., 224, 241-247(2016).   DOI
71 Zheng, W., Wu, H., Jiang, Y., Xu, J., Li, X. and Zhang, W., "A Molecularly-imprinted-electrochemical-sensor Modified with Nanocarbon-dots with High Sensitivity and Selectivity for Rapid Determination of Glucose," Anal. Biochem., 555, 42-49(2018).   DOI
72 Hartley, A. M. and Wilson, G. S., "Unusual Adsorption Effects in the Electrochemical Reduction of Flavin Mononucleotide at Mercury Electrodes," Anal. Chem., 38, 681-687(1966).   DOI
73 Roushani, M., Karami, E., Salimi, A. and Sahraei, R., "Amperometric Detection of Hydrogen Peroxide at Nano-ruthenium Oxide/riboflavin Nanocomposite-modified Glassy Carbon Electrodes," Electrochim. Acta, 113, 134-140(2013).   DOI
74 Chen, L. and Gorski, W., "Bioinorganic Composites for Enzyme Electrodes," Anal. Chem., 73, 2862-2868(2001).   DOI
75 Guo, W., Pi, F., Zhang, H., Sun, J., Zhang, Y. and Sun, X., "A Novel Molecularly Imprinted Electrochemical Sensor Modified with Carbon Dots, Chitosan, Gold Nanoparticles for the Determination of Patulin," Biosens. Bioelectron., 98, 299-304(2017).   DOI
76 Xi, J., Xie, C., Zhang, Y., Wang, L., Xiao, J. and Duan, X., "Pd Nanoparticles Decorated N-Doped Graphene Quantum Dots@NDoped Carbon Hollow Nanospheres with High Electrochemical Sensing Performance in Cancer Detection," ACS Appl. Mater. Interfaces, 8, 22563-22573(2016).   DOI
77 Guo, H., Jin, H., Gui, R., Wang, Z., Xia, J. and Zhang, F., "Electrode Position One-step Preparation of Silver Nanoparticles/carbon Dots/reduced Graphene Oxide Ternary Dendritic Nanocomposites for Sensitive Detection of Doxorubicin," Sens. Actuators B Chem., 253, 50-57(2017).   DOI
78 Bhunia, P., Hwang, E., Min, M., Lee, J., Seo, S. and Some, S., "A Non-volatile Memory Device Consisting of Graphene Oxide Covalently Functionalized with Ionic Liquid," Chem. Commun., 48, 913-915(2012).   DOI
79 Chen, D., Zhuang, X., Zhai, J., Zheng, Y., Lu, H. and Chen, L., "Preparation of Highly Sensitive Pt Nanoparticles-carbon Quantum Dots/ionic Liquid Functionalized Graphene Oxide Nanocomposites and Application for $H_2O_2$ Detection," Sens. Actuators B Chem., 255, 1500-1506(2018).   DOI
80 Huang, Q., Zhang, H., Hu, S., Li, F., Weng, W. and Chen, J., "A Sensitive and Reliable Dopamine Biosensor was Developed Based on the Au@carbon Dots-chitosan Composite Film," Biosens. Bioelectron., 52, 277-280(2014).   DOI
81 Akyildirim, O., Kardas, F., Beytur, M., Yuksek, H., Atar, N. and Yola, M. L., "Palladium Nanoparticles Functionalized Graphene Quantum Dots with Molecularly Imprinted Polymer for Electrochemical Analysis of Citrinin," J. Mol. Liq., 243, 677-681(2017).   DOI
82 Li, J., Qu, J., Yang, R., Qu, L. and Harrington, P. de B., "A Sensitive and Selective Electrochemical Sensor Based on Graphene Quantum Dot/Gold Nanoparticle Nanocomposite Modified Electrode for the Determination of Quercetin in Biological Samples," Electroanalysis, 28, 1322-1330(2016).   DOI
83 Wang, Z., Zhou, X., Zhang, J., Boey, F. and Zhang, H., "Direct Electrochemical Reduction of Single-Layer Graphene Oxide and Subsequent Functionalization with Glucose Oxidase," J. Phys. Chem. C, 113, 14071-14075(2009).   DOI
84 Tan, F., Cong, L., Li, X., Zhao, Q., Zhao, H. and Quan, X., "An Electrochemical Sensor Based on Molecularly Imprinted Polypyrrole/graphene Quantum Dots Composite for Detection of Bisphenol A in Water Samples," Sens. Actuators B Chem., 233, 599-606(2016).   DOI
85 Saha, K., Agasti, S. S., Kim, C., Li, X. and Rotello, V. M., "Gold Nanoparticles in Chemical and Biological Sensing," Chem. Rev., 112, 2739-2779(2012).   DOI
86 Tang, J., Huang, R., Zheng, S., Jiang, S., Yu, H., Li, Z., "A Sensitive and Selective Electrochemical Sensor Based on Graphene Quantum Dots/gold Nanoparticles Nanocomposite Modified Electrode for the Determination of Luteolin in Peanut Hulls," Microchem. J., 145, 899-907(2019).   DOI
87 Zhuang, Z., Lin, H., Zhang, X., Qiu, F. and Yang, H., "A Glassy Carbon Electrode Modified with Carbon Dots and Gold Nanoparticles for Enhanced Electrocatalytic Oxidation and Detection of Nitrite," Microchim. Acta, 183, 2807-2814(2016).   DOI