Browse > Article
http://dx.doi.org/10.9713/kcer.2020.58.2.286

Angular-based Measurement for Quantitative assay of Albumin in three-dimensional Paper-based analytical Device  

Kim, Dong-Ho (Department of Chemical Engineering and Applied Chemistry, Chungnam National University)
Jeong, Seong-Geun (Department of Chemical Engineering and Applied Chemistry, Chungnam National University)
Lee, Chang-Soo (Department of Chemical Engineering and Applied Chemistry, Chungnam National University)
Publication Information
Korean Chemical Engineering Research / v.58, no.2, 2020 , pp. 286-292 More about this Journal
Abstract
This study presents an angular-based measurement on three-dimensional paper-based analytical devices (3D-PADs) for quantitative detection of albumin without using an image analyzer. We demonstrate a simple quantitative and straightforward approach based on the angle of the discolored area as detection criteria. 3D-PADs are rapidly fabricated by the wax-printing and laminating process. The 3D-PADs are treated with citrate buffer and tetrabromophenol blue to react with albumin in a sample solution. Dropping sample solution into sample pad in the 3D-PAD, fluid flows toward the assay zone laterally and vertically by capillary action. We find that the change of angle of the discolored area correctly reflects the concentration of albumin and is reliable determinant for the measurement of the albumin concentration. It is the first demonstration of angular-based detection as a simple, inexpensive, and equipment-free approach for point-of-care diagnosis.
Keywords
Angular-based measurement; Paper-based analytical devices; Point-of-care diagnosis;
Citations & Related Records
Times Cited By KSCI : 12  (Citation Analysis)
연도 인용수 순위
1 Samiey, B., Alizadeh, K., Mousavi, M. F. and Alizadeh, N. "Study of Kinetics of Bromophenol Blue Fading in Alcohol-water Binary Mixtures by Sesmortac Model," Bulletin of the Korean Chemical Society, 26(3), 384-392(2005).   DOI
2 Gohain, B. and Dutta, R. K., "Premicellar and Micelle Formation Behavior of Dye Surfactant Ion Pairs in Aqueous Solutions: Deprotonation of Dye in Ion Pair Micelles," Journal of Colloid and Interface Science, 323(2), 395-402(2008).   DOI
3 Suzuki, Y., "Guidance for Selecting the Measurement Conditions in the Dyebinding Method for Determining Serum Protein: Theoretical Analysis Based on the Chemical Equilibrium of Protein Error," Analytical Sciences, 17(11), 1263-1268(2001).   DOI
4 Lee, C.-S., Lee, S.-H., Kim, Y.-G., Choi, C.-H., Kim, Y.-K. and Kim, B.-G., "Biochemical Reactions on a Microfluidic Chip Based on a Precise Fluidic Handling Method at the Nanoliter Scale," Biotechnology and Bioprocess Engineering, 11(2), 146(2006).   DOI
5 Gyure, W. L., "Comparison of Several Methods for Semiquantitative Determination of Urinary Protein," Clinical Chemistry, 23(5), 876-879(1977).   DOI
6 Jeong, S.-G., Lee, S.-H. and Lee, C.-S., "Diagnostic Paper Chip for Reliable Quantitative Detection of Albumin Using Retention Factor," KSBB Journal, 28(4), 254-259(2013).   DOI
7 Hwang, C., Jeong, S.-G., Park, H.-K., Lee, C.-S. and Kim, Y.-G., "Based Neuraminidase Assay Sensor for Detection of Influenza Viruses," Korean Chemical Engineering Research, 54(3), 380-386(2016).   DOI
8 Jeong, S.-G., Lee, S.-H., Choi, C.-H., Kim, J. and Lee, C.-S. "Toward Instrument-free Digital Measurements: a Three-dimensional Microfluidic Device Fabricated in a Single Sheet of Paper by Double-sided Printing and Lamination," Lab on a Chip, 15(4), 1188-1194(2015).   DOI
9 Washburn, E. W., "Note on a Method of Determining the Distribution of Pore Sizes in a Porous Material," Proceedings of the National Academy of Sciences of the United States of America, 7(4), 115(1921).   DOI
10 Carrilho, E., Martinez, A. W. and Whitesides, G. M., "Understanding Wax Printing: a Simple Micropatterning Process for Paperbased Microfluidics," Analytical Chemistry, 81(16), 7091-7095(2009).   DOI
11 Compton, S. J. and Jones, C. G., "Mechanism of Dye Response and Interference in the Bradford Protein Assay," Analytical Biochemistry, 151(2), 369-374(1985).   DOI
12 Cao, W., Jiao, Q., Fu, Y., Chen, L. and Liu, Q., "Mechanism of the Interaction Between Bromophenol Blue and Bovine Serum Albumin," Spectroscopy Letters - Spectrosc Lett, 36, 197-209(2003).   DOI
13 Kong, T., You, J. B., Zhang, B., Nguyen, B., Tarlan, F., Jarvi, K. and Sinton, D., "Accessory-free Quantitative Smartphone Imaging of Colorimetric Paper-based Assays," Lab on a Chip, 19(11), 1991-1999(2019).   DOI
14 Morbioli, G. G., Mazzu-Nascimento, T., Stockton, A. M. and Carrilho, E., "Technical Aspects and Challenges of Colorimetric Detection with Microfluidic Paper-based Analytical Devices (${\mu}PADs$) - A Review," Analytica Chimica Acta, 970, 1-22(2017).   DOI
15 Kim, S., Kim, D. and Kim, S., "A Rapid Real-time Quantification in Hybrid Paper-polymer Centrifugal Optical Devices," Biosensors and Bioelectronics, 126, 200-206(2019).   DOI
16 Christwardana, M., Chung, Y., Tannia, D. C. and Kwon, Y. "Effects of the Gold Nanoparticles Including Different Thiol Functional Groups on the Performances of Glucose-oxidase-based Glucose Sensing Devices," Korean Journal of Chemical Engineering, 35(12), 2421-2429(2018).   DOI
17 Peeling, R. W., Holmes, K. K., Mabey, D. and Ronald, A., "Rapid Tests for Sexually Transmitted Infections (STIs): the Way Forward," Sexually Transmitted Infections, 82(suppl 5), v1-v6(2006).   DOI
18 Park, Y. and Lee, H., "The Levels of Physical Activity and Its Relationships with Depression, Health-related Quality of Life, Sleep Disturbance, and Physiological Indicators in Hemodialysis Patients," Korean Journal of Adult Nursing, 27(6), 718-727 (2015).   DOI
19 Na, K., "New Oral Agent for Treatment of Anemia in Patient with Chronic Kidney Disease: Prolyl Hydroxylase Inhibitor," The Korean Journal of Medicine, 94(1), 11-16(2019).   DOI
20 Gervais, L., De Rooij, N. and Delamarche, E., "Microfluidic Chips for Point of Care Immunodiagnostics," Advanced Materials, 23(24), H151-H176(2011).   DOI
21 Park, S. J., Kim, S., Kim, S. H., Park, K. M. and Hwang, B. H. "His-tagged Protein Immobilization on Cationic Ferrite Magnetic Nanoparticles," Korean Journal of Chemical Engineering, 35(6), 1297-1302(2018).   DOI
22 Son, J., Hwang, J., Lee, D., Khan, M. S., Jo, Y., Lee, K., Park, C., Chavan, S., Seo, Y. and Choi, Y., "Strategies for the Optimization of Bead-immunoassays for the Effective Detection of Target Biomolecules," Korean Journal of Chemical Engineering, 35(3), 805-811(2018).   DOI
23 Lee, M., Kim, J.-H. and Koo, H.-J., "Dielectrophoresis for Control of Particle Transport: Theory, Electrode Designs and Applications," Korean Chemical Engineering Research, 57(2), 149-163 (2019).
24 Heo, N. S., Oh, S. Y., Ryu, M. Y., Baek, S. H., Park, T. J., Choi, C., Huh, Y. S. and Park, and J. P., "Affinity Peptide-guided Plasmonic Biosensor for Detection of Noroviral Protein and Human Norovirus," Biotechnology and Bioprocess Engineering, 24(2), 318-325(2019).   DOI
25 Zhou, M., Yang, M. and Zhou, F., "Paper Based Colorimetric Biosensing Platform Utilizing Cross-linked Siloxane as Probe," Biosensors and Bioelectronics, 55, 39-43(2014).   DOI
26 Chin, C. D., Linder, V. and Sia, S. K., "Lab-on-a-chip Devices for Global Health: Past Studies and Future Opportunities," Lab on a Chip, 7(1), 41-57(2007).   DOI
27 Mu, X., Zhang, L., Chang, S., Cui, W. and Zheng, Z., "Multiplex Microfluidic Paper-based Immunoassay for the Diagnosis of Hepatitis C Virus Infection," Analytical Chemistry, 86(11), 5338-5344(2014).   DOI
28 Shin, J.-W., Yoon, J., Shin, M., Choi, and J.-W., "Electrochemical Dopamine Biosensor Composed of Silver Encapsulated $MoS_2$ Hybrid Nanoparticle," Biotechnology and Bioprocess Engineering, 24(1), 135-144(2019).   DOI
29 Hong, W., Jeong, S.-G., Shim, G., Kim, D. Y., Pack, S. P. and Lee, C.-S., "Improvement in the Reproducibility of a Paper-based Analytical Device (PAD) Using Stable Covalent Binding between Proteins and Cellulose Paper," Biotechnology and Bioprocess Engineering, 23(6), 686-692(2018).   DOI
30 Maharjan, A., Alkotaini, B. and Kim, B. S. "Fusion of Carbohydrate Binding Modules to Bifunctional Cellulase to Enhance Binding Affinity and Cellulolytic Activity," Biotechnology and Bioprocess Engineering, 23(1), 79-85(2018).   DOI
31 Hinberg, I. H., Katz, L. and Waddell, L. "Sensitivity of in vitro Diagnostic Dipstick Tests to Urinary Protein," Clinical Biochemistry, 11(2), 62-64(1978).   DOI
32 Bae, E., Park, H.-J., Yoon, J., Kim, Y., Choi, K. and Yi, J., "Bacterial Uptake of Silver Nanoparticles in the Presence of Humic Acid and $AgNO_3$," Korean Journal of Chemical Engineering, 28(1), 267-271(2011).   DOI
33 Yu, J. H., Jeong, S.-G., Lee, C.-S., Hwang, J.-Y., Kang, K.-T., Kang, H. and Lee, S.-H., "Fabrication of a Paper-based Analytical Device for Multiple Colorimetric Analysis via Inkjet-printing and Paper-cutting," BioChip Journal, 9(2), 139-143(2015).   DOI
34 Kolthoff, I. M. and Elving, P. J., Treatise on Analytical Chemistry, Part 1 (Vol. 13). John Wiley & Sons(1993).
35 Duy, L. T., Trung, T. Q., Dang, V. Q., Hwang, B.-U., Siddiqui, S., Son, I.-Y., Yoon, S. K., Chung, D. J. and Lee, N.-E., "Flexible Transparent Reduced Graphene Oxide Sensor Coupled with Organic Dye Molecules for Rapid Dual-Mode Ammonia Gas Detection," Advanced Functional Materials, 26(24), 4329-4338(2016).   DOI