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http://dx.doi.org/10.9713/kcer.2018.56.6.832

Study on Benzo(a)pyran Content and its Transfer Ratio in Extracts of Medicinal Herbs  

Yoon, Hye-Min (Department of Chemical Engineering, Daegu University)
Lee, Eun Ju (Department of Chemical Engineering, Daegu University)
Lim, Kwang-Hee (Department of Chemical Engineering, Daegu University)
Publication Information
Korean Chemical Engineering Research / v.56, no.6, 2018 , pp. 832-840 More about this Journal
Abstract
In this study, both of the concentration of benzo(a)pyrene in 5 species (total 50 samples) of medicinal herbs and their transfer ratios in the preparation steps of water extract(decoction) and soft extract, were measured by HPLC/FLD. The calibration curve of benzo(a)pyrene shows excellent correlation over the concentration range of 3~40 ng/mL with the correlation coefficient ($R^2$) of 1.000. The detected benzo(a)pyrene concentrations from the medicinal herbs ranged from non-detection to $37.54{\mu}g/kg$, and their average was $6.73{\mu}g/kg$. Among the total samples, 15 samples (i.e., 30%) exceeded the limit of herbal medicine benzo(a)pyrene criteria (i.e., $5{\mu}g/kg$) according to the notification No. 2009-302 from Ministry of Food and Drug Safety. In particular, the concentration of benzo(a)pyrene in Coptidis Rhizome was turned out to be the highest of $37.54{\mu}g/kg$. The detected benzo(a)pyrene concentrations from water extract(decoction), soft extract and remnant after boiling, ranged from non-detection to $2.31{\mu}g/kg$, non-detection to $2.28{\mu}g/kg$, and 2.18 to $21.91{\mu}g/kg$, respectively. In preparation of water extract(decoction) and soft extract, transferred benzo(a)pyrene was not detected or, if transferred, the maximal transfer ratios of benzo(a)pyrene were shown to be 8.9% and 9.8%, respectively. Therefore, the content of benzo(a)pyrene in the samples of herbal medicine used in this study, were reduced by more than 90% in preparation steps of water extract (decoction) and soft extract.
Keywords
Medicinal herbs; Benzo(a)pyrene; Transfer ratio; Water extract; Soft extract; HPLC;
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Times Cited By KSCI : 6  (Citation Analysis)
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