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http://dx.doi.org/10.9713/kcer.2017.55.5.600

Explosion Hazard Assessment of Pharmaceutical Raw Materials Powders  

Lee, Joo Yeob (Occupational Safety & Health Research Institute, KOSHA)
Lee, Keun Won (Occupational Safety & Health Research Institute, KOSHA)
Park, Sang Yong (Occupational Safety & Health Research Institute, KOSHA)
Han, In Soo (Occupational Safety & Health Research Institute, KOSHA)
Publication Information
Korean Chemical Engineering Research / v.55, no.5, 2017 , pp. 600-608 More about this Journal
Abstract
Hazard risk of explosion on pharmaceutical raw materials dust in pharmaceutical industry often exists when it is handled or processed in the industrial sites, and explosion accident is caused by this. In this study, the dust explosion characteristics of the three pharmaceutical raw materials samples were measured. The main explosion characteristics are as follows: $P_{max}$, MIE and MIT of loxoprofen acid having $5.31^{\circ}C$ of median diameter are obtained 8.4 bar, 1 mJ < MIE < 3 mJ and $550^{\circ}C$. $P_{max}$, MIE and MIT of camphorsulfonate having $95.63^{\circ}C$ of median diameter are obtained 7.9 bar, 30 mJ < MIE < 100 mJ and $510^{\circ}C$. $P_{max}$, MIE and MIT of rifampicine having $26.48^{\circ}C$ of median diameter are obtained 7.9 bar and 1 mJ < MIE < 3 mJ and $470^{\circ}C$. The deflagration index ($K_{st}$) and the explosion index (EI) were obtained by using these data. The explosion hazard assessment of pharmaceutical raw materials dust was compared and examined. As a result, the explosion hazard assessment according to deflagration index and explosion index were the explosion class with St 2 and the explosion hazard rating of severe for loxoprofen acid & rifampicine and St 1 and strong for clopidogrel camphorsulfonate, respectively.
Keywords
Loxoprofen acid; Clopidogrel camphorsulfonate; Rifampicine; Pharmaceutical raw materials; Dust explosion characteristics; Deflagration index; Explosion index;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
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