Browse > Article
http://dx.doi.org/10.9713/kcer.2013.51.5.597

Fabrication of Polymeric Microcapsules in a Microchannel using Formation of Double Emulsion  

Nam, Jin-Oh (Department of Chemical Engineering, Chungnam National University)
Choi, Chang-Hyung (Department of Chemical Engineering, Chungnam National University)
Kim, Jongmin (Department of Chemical Engineering, Chungnam National University)
Kang, Sung-Min (Department of Chemical Engineering, Chungnam National University)
Lee, Chang-Soo (Department of Chemical Engineering, Chungnam National University)
Publication Information
Korean Chemical Engineering Research / v.51, no.5, 2013 , pp. 597-601 More about this Journal
Abstract
In this study, we present simple microfluidic approach for the synthesis of monodisperse microcapsules by using droplet-based system. We generate double emulsion through single step in the microfluidic device having single junction while conventional approaches are limited in surface treatment for the generation of double emulsion. First, we have injected disperse fluid containing FC-77 oil and photocurable ethoxylated trimethylolpropane triacrylate (ETPTA) and water containing 3 wt% poly(vinyl alcohol) (PVA) as continuous phase into microfluidic device. Under the condition, we easily generate double emulsion with high monodispersity by using flow focusing. The double emulsion droplets are transformed into microcapsules under the UV irradiation via photopolymerization. In addition, we control thickness of double emulsion's shell by controlling flow rate of ETPTA. We also show that the size of double emulsions can be controlled by manipulation of flow rate of continuous phase. Furthermore, we synthesize microcapsules encapsulating various materials for the application of drug delivery systems.
Keywords
Double Emulsion; Microcapsule; Photopolymerization; Monodispersity; Microfluidics;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Xu, S. Q., Nie, Z. H., Seo, M., Lewis, P., Kumacheva, E., Stone, H. A., Garstecki, P., Weibel, D. B., Gitlin, I. and Whitesides, G. M., "Generation of Monodisperse Particles by Using Microfluidics: Control over Size, Shape, and Composition," Angew. Chem.-Int. Edit., 44(5), 724-728(2005).   DOI   ScienceOn
2 Hennequin, Y., Pannacci, N., de Torres, C. P., Tetradis-Meris, G., Chapuliot, S., Bouchaud, E. and Tabeling, P., "Synthesizing Microcapsules with Controlled Geometrical and Mechanical Properties with Microfluidic Double Emulsion Technology," Langmuir, 25(14), 7857-7861(2009).   DOI   ScienceOn
3 Freiberg, S. and Zhu, X., "Polymer Microspheres for Controlled Drug Release," Int. J. Pharm., 282(1-2), 1-18(2004).   DOI   ScienceOn
4 Ichikawa, H. and Fukumori, Y., "A Novel Positively Thermosensitive Controlled-release Microcapsule with Membrane of Nano-sized Poly(N-isopropylacrylamide) Gel Dispersed in Ethylcellulose Matrix," J. Control., 63(1-2), 107-119(2000).   DOI   ScienceOn
5 Yoshida, K., Sekine, T., Matsuzaki, F., Yanaki, T. and Yamaguchi, M., "Stability of Vitamin A in Oil-in-water-in-oil-type Multiple Emulsions," J. Am. Oil. Chem. Soc., 76(2), 195-200(1999).
6 Kim, S. H., Abbaspourrad, A. and Weitz, D. A., "Amphiphilic Crescent-Moon-Shaped Microparticles Formed by Selective Adsorption of Colloids," J. Am. Chem. Soc., 133(14), 5516-5524(2011).   DOI   ScienceOn
7 Hwang, S., Choi, C. H., Kim, H. C., Kim, I. H. and Lee, C. S., "In situ Microfluidic Method for the Generation of Monodisperse Double Emulsions," Polym.(Korea), 36(2), 177-181(2012).   과학기술학회마을   DOI   ScienceOn
8 Harry, R. A., James, F. W. L. and Mark, E., Contemporary Polymer Chemistry. 3rd ed., Prentice Hall, Englewood Cliffs, NJ(2003).
9 Karapanagiotis, I. and Gerberich, W. W., "Polymer Film Rupturing in Comparison with Leveling and Dewetting," Surf. Sci., 594(1-3), 192-202(2005).   DOI   ScienceOn
10 Choi, C. H., Yi, H., Hwang, S., Weitz, D. A. and Lee, C. S., "Microfluidic Fabrication of Complex-shaped Microfibers by Liquid Template-aided Multiphase Microflow," Lab Chip, 11(8), 1477-1483(2011).   DOI   ScienceOn
11 Choi, C. H., Jung, J. H. and Lee, C. S., "In situ Microfluidic Method for the Generation of Uniform PEG Microfiber," Korean Chem. Eng. Res.(HWAHAK KONGHAK), 48(4), 470-474(2010).
12 Choi, C. H., Jung, J. H., Rhee, Y. W., Kim, D. P., Shim, S. E. and Lee, C. S., "Generation of Monodisperse Alginate Microbeads and in situ Encapsulation of Cell in Microfluidic Device," Biomed. Microdevices, 9(6), 855-862(2007).   DOI   ScienceOn
13 Kang, S. M., Choi, C. H., Hwang, S., Jung, J. M. and Lee, C. S., "Microfluidic Preparation of Monodisperse Multiple Emulsion Using Hydrodynamic Control," Korean Chem. Eng. Res.(HWAHAK KONGHAK), 50(4), 733-737(2012).   과학기술학회마을   DOI   ScienceOn
14 Choi, C. H., Jung, J. H., Hwang, T. S. and Lee, C. S., "In Situ Microfluidic Synthesis of Monodisperse PEG Microspheres," Macromol. Res., 17(3), 163-167(2009).   DOI   ScienceOn
15 Jung, J. H., Choi, C. H., Hwang, T. S. and Lee, C. S., "Efficient In situ Production of Monodisperse Polyurethane Microbeads in Microfluidic Device using Increase of Residence Time of Droplets," Biochip J., 3(1), 44-49(2009).
16 Utada, A. S., Lorenceau, E., Link, D. R., Kaplan, P. D., Stone, H. A. and Weitz, D. A., "Monodisperse Double Emulsions Generated from a Microcapillary Device," Science, 308(5721), 537-541(2005).   DOI   ScienceOn
17 Deng, N. N., Meng, Z. J., Xie, R., Ju, X. J., Mou, C. L., Wang, W. and Chu, L. Y., "Simple and Cheap Microfluidic Devices for the Preparation of Monodisperse Emulsions," Lab Chip, 11(23), 3963-3969(2011).   DOI   ScienceOn
18 Abate, A. R. and Weitz, D. A., "High-Order Multiple Emulsions Formed in Poly(dimethylsiloxane) Microfluidics," Small, 5(18), 2030-2032(2009).   DOI   ScienceOn
19 Hwang, S., Choi, C. H. and Lee, C. S., "Regioselective Surface Modification of Pdms Microfluidic Device for the Generation of Monodisperse Double Emulsions," Macromol. Res., 20(4), 422-428(2012).   DOI   ScienceOn
20 Bauer, W. A. C., Fischlechner, M., Abell, C. and Huck, W. T. S., "Hydrophilic PDMS Microchannels for High-throughput Formation of Oil-in-water Microdroplets and Water-in-oil-in-water Double Emulsions," Lab Chip, 10(14), 1814-1819(2010).   DOI   ScienceOn
21 Esser-Kahn, A. P., Sottos, N. R., White, S. R. and Moore, J. S., "Programmable Microcapsules from Self-Immolative Polymers," J. Am. Chem. Soc., 132(30), 10266-10268(2010).   DOI   ScienceOn
22 Vasiljevic, D., Parojcic, J., Primorac, M. and Vuleta, G., "An Investigation into the Characteristics and Drug Release Properties of Multiple W/O/W Emulsion Systems Containing Low Concentration of Lipophilic Polymeric Emulsifier," Int. J. Pharm., 309(1-2), 171-177(2006).   DOI   ScienceOn
23 Elsoda, M., Pannell, L. and Olson, N., "Microencapsulated Enzyme-Systems for the Acceleration of Cheese Ripening," J. Microencapsul., 6(3), 319-326(1989).   DOI
24 Bonilla, E., Azuara, E., Beristain, C. I. and Vernon-Carter, E. J., "Predicting Suitable Storage Conditions for Spray-dried Microcapsules Formed with Different Biopolymer Matrices," Food Hydrocolloids, 24(6-7), 633-640(2010).   DOI   ScienceOn
25 Kurayama, F., Yoshikawa, T., Furusawa, T., Bahadur, N. M., Handa, H., Sato, M. and Suzuki, N., "Microcapsule with a Heterogeneous Catalyst for the Methanolysis of Rapeseed Oil," Bioresour. Technol., 135, 652-658(2013).   DOI   ScienceOn
26 Chen, P. W., Erb, R. M. and Studart, A. R., "Designer Polymer-Based Microcapsules Made Using Microfluidics," Langmuir, 28(1), 144-152(2012).   DOI   ScienceOn
27 Nisisako, T., "Microstructured Devices for Preparing Controlled Multiple Emulsions," Chem. Eng. Technol., 31(8), 1091-1098(2008).   DOI   ScienceOn
28 Jung, J. H. and Lee, C. S., "Droplet Based Microfluidic System," Korean Chem. Eng. Res.(HWAHAK KONGHAK), 48(5), 545-555(2010).
29 Anna, S. L., Bontoux, N. and Stone, H. A., "Formation of Dispersions Using "Flow Focusing" in Microchannels," Appl. Phys. Lett., 82(3), 364-366(2003).   DOI   ScienceOn