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http://dx.doi.org/10.9713/kcer.2013.51.5.591

Ursolic Acid Isolated from Mume Fructus Inhibits Urease Activity of Helicobacter pylori  

Park, Chan-El (Dalim Biotech, Central Research Center)
Park, Chang-Ho (Department of Chemical Engineering, Kyung Hee University)
Publication Information
Korean Chemical Engineering Research / v.51, no.5, 2013 , pp. 591-596 More about this Journal
Abstract
Urease activity of Helicobacter pylori was most strongly inhibited by extract of Mume Fructus among ethanol (70%, v/v) extract of 6 herbal materials selected from our previous work, database on traditional herbal materials, and literature data on Korean plant resources. Active compounds in the extract of Mume Fructus were separated by batch extraction, and further purified by chromatography in a silica gel column and an octadecyl silica gel column using solvents of different polarity. By NMR analysis of the last chromatographic fraction we identified ursolic acid as the active compound of urease inhibition. The result suggests that this component in Mume Fructus can possibly be used for the eradication of H. pylori.
Keywords
Mume Fructus; Urease Activity; Helicobacter pylori; Extraction; NMR Analysis;
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