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http://dx.doi.org/10.9713/kcer.2012.50.4.733

Microfluidic Preparation of Monodisperse Multiple Emulsion using Hydrodynamic Control  

Kang, Sung-Min (Department of Chemical Engineering, Chungnam National University)
Choi, Chang-Hyung (Department of Chemical Engineering, Chungnam National University)
Hwang, Sora (Department of Chemical Engineering, Chungnam National University)
Jung, Jae-Min (Department of Chemical Engineering, Chungnam National University)
Lee, Chang-Soo (Department of Chemical Engineering, Chungnam National University)
Publication Information
Korean Chemical Engineering Research / v.50, no.4, 2012 , pp. 733-737 More about this Journal
Abstract
This study reports the microfluidic preparation of monodisperse multiple emulsions using hydrodynamic control. To generate multiple emulsions, we fabricate a microfluidic capillary device based on co-flowing stream without any surface modification of microchannels. Based on the system, we can successfully generate multiple emulsions (W/O/W) using water containing 0.5 wt% Tween 20, n-hexadecane with 5 wt% Span 80, and 10 wt% poly (vinyl alcohol) (PVA) aqueous solution, respectively. Furthermore, we control the number of inner droplets by modulation of flow rate of inner fluid at fixed flow rate of middle and outer fluid. The multiple emulsions having precisely controlled inner droplets' size and number can be applicable for multiple chemical reactions as an isolated microreactor.
Keywords
Microfluidics; Multiple Emulsions; Hydrodynamic Control; Monodispersity; Capillary;
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Times Cited By KSCI : 1  (Citation Analysis)
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1 Goubault, C., Pays, K., Olea, D., Gorria, P., Bibette, J., Schmitt, V. and Leal-Calderon, F., "Shear Rupturing of Complex Fluids: Application to the Preparation of Quasi-monodisperse Water-inoil-in-water Double Emulsions," Langmuir, 17, 5184-5188(2001).   DOI   ScienceOn
2 Matsumoto, S., Kita, Y. and Yonezawa, D., "An Attempt at Preparing Water-in-oil-in-water Multiple-phase Emulsions," J. Colloid Interface Sci., 57, 353-361(1976).   DOI   ScienceOn
3 Nakashima, T., Shimizu, M. and Kukizaki, M., "Particle Control of Emulsion by Membrane Emulsification and its Application," Adv. Drug Delivery Rev., 45, 47-56(2000).   DOI   ScienceOn
4 Nie, Z. H., Xu, S. Q., Seo, M., Lewis, P. C. and Kumacheva, E., "Polymer Particles with Various Shapes and Morphologies Produced in Continuous Microfluidic Reactors," J. Am. Chem. Soc., 127(22), 8058-8063(2005).   DOI   ScienceOn
5 Vladisvljevic, G. T., Shimizu, M. and Nakashima, T., "Production of Multiple Emulsions for Drug Delivery Systems by Repeated SPG Membrane Homogenization: Influence of Mean Pore Size, Interfacial Tension and Continuous Phase Viscosity," J. Membr. Sci., 284(1-2), 373-383(2006).   DOI   ScienceOn
6 Choi, C. H., Yi, H., Hwang, S., Weitz, D. A. and Lee, C. S., "Microfluidic Fabrication of Complex-shaped Microfibers by Liquid Template-aided Multiphase Microflow," Lab Chip, 11(8), 1477-1483(2011).   DOI   ScienceOn
7 Jung, J. H., Choi, C. H., Hwang, T. S. and Lee, C. S., "Efficient in situ Production of Monodisperse Polyurethane Microbeads in Microfluidic Device Using Increase of Residence Time of Droplets", Biochip Journal, 3(1), 44-49(2009).
8 Jung, J. H., Choi, C. H., Hwang, T. S. and Lee, C. S., "In situ Microfluidic Synthesis of Monodisperse PEG Microspheres," Macromol. Res., 17(3), 163-167(2009).   DOI   ScienceOn
9 Choi, C. H., Jung, J. H., Yoon, T. H., Kim, D. P. and Lee, C. S., "The Effect of Microfluidic Geometry for in situ Generating Monodispersed Hydrogels," J. Chem. Eng. Jpn., 41(7), 649-654(2008).   DOI   ScienceOn
10 Kim, S. H., Jeon, S. J., Jeong, W. C., Park, H. S. and Yang, S. M., "Optofluidic Synthesis of Electroresponsive Photonic Janus Balls With Isotropic Structural Colors," Adv. Mater., 20(21), 4129-4134(2008).
11 Davis, S. S. and Walker, I. M., "Multiple Emulsions as Targetable Delivery Systems," Methods Enzymol., 149, 51-64(1987).   DOI
12 Lorenceau, E., Utada, A. S., Link, D. R., Cristobal, G., Joanicot, M. and Weitz, D. A., "Generation of Polymersomes from Double- emulsion," Langmuir, 21(20), 9183-9186(2005).   DOI   ScienceOn
13 Pays, K., Giermanska-Kahn, J., Pouligny, B., Bibette, J. and Leal- Calderon, F., "Double Emulsion: How Does Release Occur?," J. Controlled Release, 79, 193-205(2002).   DOI   ScienceOn
14 Mason, T. G. and Bibette, J., "Shear Rupturing of Droplets in Complex Fluids," Langmuir, 13(17), 4600-4613(1997).   DOI   ScienceOn
15 Kobayashi, I., Uemura, K. and Nakajima, M., "Formulation of Monodisperse Emulsions Using Submicron-channel Arrays," Colloids Surf. A: Physicochem Eng. Asp., 296(1-3), 285-289(2007).   DOI   ScienceOn
16 Hwang, S., Choi, C. H., Kim, H. C., Kim, I. H. and Lee, C. S., "In situ Microfluidic Method for the Generation of Monodisperse Double Emulsions," Polymer(Korea), 36, 1-5(2012).   과학기술학회마을   DOI   ScienceOn
17 Umbanhowar, P. B., Prasad, V. and Weitz, D. A., "Monodisperse Emulsion Generation Via Drop Break off in a Coflowing Stream," Langmuir, 16(2), 347-351(2000).   DOI   ScienceOn
18 Schmitt, V., Leal-Calderon, F. and Bibette, J., "Preparation of Monodisperse Particles and Emulsions by Controlled Shear," Top. Curr. Chem., 227, 195-215(2003).   DOI
19 Whitesides, G. M., "The Origins and the Future of Microfluidics," Nature, 442(7101), 368-373(2006).   DOI   ScienceOn
20 Jung, J. H. and Lee, C. S., "Droplet Based Microfluidic System," Korean Chem. Eng. Res. (HWAHAK KONGHAK), 48, 545-555(2010).
21 Fair, R., "Digital Microfluidics: Is a True Lab-on-a-chip Possible?", Microfluidics and Nanofluidics, 3(3), 245-281(2007).   DOI   ScienceOn
22 Duffy, D. C., McDonald, J. C., Schueller, O. J. A. and Whitesides, G. M., "Rapid Phototyping of Microfluidic Systems in Poly(dimethylsiloxane)," Anal Chem, 70(23), 4974-4984(1998).   DOI   ScienceOn
23 Chu, L. Y., Utada, A. S., Shah, R. K., Kim, J. W. and Weitz, D. A., "Controllable Monodisperse Multiple Emulsions," Angew. Chem., Int. Ed., 46, 8970-8974(2007).   DOI   ScienceOn
24 Utada, A. S., Lorenceau, E., Link, D. R., Kaplan, P. D., Stone, H. A. and Weitz, D. A., "Monodisperse Double Emulsions Generated from a Microcapillary Device," Science, 308, 537-541(2005).   DOI   ScienceOn
25 Vasiljevic, D., Parojcic, J., Primorac, M. and Vuleta, G., "An Investigation into the Characteristics and Drug Release Properties of Multiple W/O/W Emulsion Systems Containing low Concentration of Lipophilic Polymeric Emulsifier", Int. J. Pharm, 309(1-2), 171-177(2006).   DOI   ScienceOn
26 Yoshida, K., Sekine, T., Matsuzaki, F., Yanaki, T. and Yamaguchi, M., "Stability of Vitamin A in Oil-in-water-in-oil-type Multiple Emulsions," J. Am. Oil Chem. Soc., 76(2), 195-200(1999).
27 Lee, M. H., Oh, S. G., Moon, S. K. and Bae, S. Y., "Preparation of Silica Particles Encapsulating Retinol Using O/W/O Multiple Emulsions," J. Colloid Interface Sci., 240(1), 83-89(2001).   DOI   ScienceOn