Browse > Article

Drowning-out Crystallization of Calcium Lactate for Crystal Size Control  

Kim, Jong-Min (Department of Chemical Engineering, Dong A University)
Chang, Sang Mok (Department of Chemical Engineering, Dong A University)
Kim, In-Ho (Department of Chemical Engineering, Chungnam University)
Koo, Yoon-Mo (Department of Biochemical Engineering, Inha University)
Hong, Haehyun (Department of Chemical Engineering, ILRI, Kyunghee University)
Kim, Woo-Sik (Department of Chemical Engineering, ILRI, Kyunghee University)
Publication Information
Korean Chemical Engineering Research / v.47, no.6, 2009 , pp. 740-746 More about this Journal
Abstract
In the present study, the drowning-out crystallization of L(+)-calcium lactate was investigated in order to develop the crystallization separation process. The crystallization of the calcium lactate was induced by injecting the alcoholic anti-solvent into the aqueous solution of calcium lactate and the control of the calcium lactate crystal size during the crystallization was primarily investigated under the consideration of the anti-solvent species, anti-solvent composition and agitation speed as the key operating factors. Alcohols of methanol, ethanol, n-propanol and i-propanol were used as the anti-solvent for the drowning-out crystallization. Prior to the crystallization experiment, the solubility of calcium lactate in the water-alcohol mixture was measured along with the variation of the alcohol species and composition, which was necessary to estimate the supersaturation level of the crystallization. By the drowning-out crystallization, the calcium lactate crystals of the fabric shape were obtained. Using the ethanol as the antisolvent, the fabric crystals close to the needle shape were produced. However, the hairy crystals were obtained by using the propanol as the anti-solvent. Due to such morphological features, the crystals was highly apt to form the aggregates. The aggregation of the crystals was intensified as increasing the alcohol fraction in the water-alcohol mixture. Meanwhile, the agitation caused the breakage of crystals, resulting in the decrease of the crystal size. Therefore, the crystal size in the crystallization was predominantly determined by the competition between the crystal aggregation and breakage.
Keywords
Calcium Lactate; Crystallization; Anti-Solvent; Agitation; Crystal Size; Aggregation; Breakage;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Mullin, J. W., Crystallization, Butterworth-Heinemann, Third edition,172-201(1993)
2 Berry, D. A., Dye, S. R. and Ng, K. M., "Synthesis of Drowningout Crystallization-Based Separations," AIChE J., 43, 91-103(1997)   DOI   ScienceOn
3 Ruiz, G. V. F., De Vera, G., Lopez, E. and Saquete, M. D., "Liquid- Liquid-solid Equilibria for the Ternary Systems Water-Sodium Chloride or Potassium Chloride-1-Propanol or 2-Propanol," Fluid Phase Equilib., 98, 141-147(1994)   DOI   ScienceOn
4 Zepeta, I. V., Lozano, F. and Garfias, F. J., "Liquid-Liquid Equilibrium for the Ternary System NaOH-$H_2O$-BuOH," J. Chem. Eng. Data, 24(4), 287-289(1979)   DOI
5 Teresa, S. and Xavier, C., 'Effect of the Shear and Volume Fraction on the Aggregation and Breakup of Particles,' AIChE. J., 44,1724-1730(1998)   DOI   ScienceOn
6 Mersmann, A. and Kind, M., 'Chemical Engineering Aspects of Precipitation from Solutions,' Trans. Ind. Chem. Eng., 11, 264-276 (1990)   DOI   ScienceOn
7 McCabe, W. L., Smith, J. C. and Harriott, P., Unit Operation of Chemical Engineering, 5th, McGraw-Hill, 242(1993)
8 Ho-Gutierrez, I. V., Cheluget, E. L., Vera, J. H. and Weber, M. E., "Liquid-Liquid Equilibrium of Aqueous Mixtures of Poly(Ethylene Glycol) with $Na_2SO_4$ or NaCl", J. Chem. Eng. Data, 39, 245- 248(1994)   DOI   ScienceOn
9 Dorn, F., Smith, Jr. G. L. and McKenna, J. C., "The System $CuCl_2$- $CH_3OH-C_4H_8O_2 $ at 30.0 oC. 3-Copper (II) Chloride-Bis (1,4-) Dioxane," J. Chem. Eng. Data, 10(2), 195-196(1965)   DOI
10 Masy, J. C. and Cournil, M., "Using a Turbidimetric Method to Study the Kinetics of Agglomeration of Potassium Sulfate in a Liquid Medium," Chem. Eng. Sci., 46, 693-701(1991)   DOI   ScienceOn
11 Teresa, S., Jordi, C. and Xavier, C., "Aggregation and Breakup of Particles in a Shear Flow," J. Colloid Interf. Sci., 187, 466-473 (1997)   DOI   ScienceOn
12 Iyer, H. V. and Przybycien, P. M., "Metal Affinity Protein Precipitation. Effects of Mixing, Protein Concentration, and Modifiers on Protein Fractionation," Biotechnol. Bioeng., 48, 324-332 (1995)   DOI   ScienceOn
13 Plasari, E., Grisoni, P. H. and Millermaux, J., "Influence of Process Parameters on the Precipitation of Organic Nanoparticles by Drowning-out," Trans IChemE., 75, Part A, 237-244(1997)   DOI   ScienceOn
14 Alfassi, Z. B. and Mosseri, S., "Solventing out of Electrolytes from their Aqueous Solution," AIChE J. 30, 874-876(1984)   DOI
15 Francis, A. W., "Ternary Systems of Liquid Carbon Dioxide," J. Phys. Chem., 58, 1099-1114(1954)   DOI
16 Jagadesh, D., Chivate, M. R. and Tavare, N. S., "Batch Crystallization of Potassium Chloride by an Ammoniation Process," Ind. Eng. Chem. Res. 31, 561-568(1992)   DOI