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Micro- and Nanoparticle Preparation of Methacrylic Acid-Methyl Methacrylate Copolymer and Lactocin  

Yun, Hye Ri (Department Chemical Engineering and Materials Science, Chung-Ang University)
Lee, Jonghwi (Department Chemical Engineering and Materials Science, Chung-Ang University)
Publication Information
Korean Chemical Engineering Research / v.46, no.2, 2008 , pp. 222-226 More about this Journal
Abstract
Nanoparticles have been developed and applied for various applications to intelligently deliver bioactive materials. Herein, lactocin was processed into nanoparticles with methacrylic acid-methyl methacrylate copolymer (1:1) (eudragit L100). The eudragit polymer can protect lactocin from the stomach acid and release lactocin in the intestines. When acetone and pH 7 buffer solution were used as non-solvent and solvent, respectively, the smallest volume-average particle size (290 nm) could be obtained. Freeze drying in presence of carrageenan (dispersant) can process the particles into dried powders with minimum aggregation. SEM observation revealed the primary particles prepared based on lactocin and eudragit were of a few tens of nanometers.
Keywords
Nanoparticle; Microparticle; Eudragit; Lactocin; Aggregation;
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