Browse > Article

Enhanced Transdermal Permeation Effects of Lidocaine Gel by Low Frequency Ultrasound  

Jung, Dae-In (Department of Physical Therapy, Gwangju Health College)
Lee, Jung-Woo (Department of Physical Therapy, Kwangju Women's University)
Ahn, Hyo-Cho (College of Parmacy, Woosuk University)
Yang, Jae-Heon (College of Parmacy, Woosuk University)
Kim, Tae-Youl (Department of Physical Therapy, Dongshin University)
Cho, Seong-Wan (Department of Pharmaceutical Engineering, Konyang University)
Kim, Young-Il (Department of Pharmaceutical Engineering, Konyang University)
Publication Information
Korean Chemical Engineering Research / v.46, no.2, 2008 , pp. 217-221 More about this Journal
Abstract
To investigate the enhancing effects in transdermal permeation of drug using newly designed ultrasound apparatus of 500 kHz, the transdermal permeation studies through the hairless mouse skin were conducted with lidocaine. The ultrasound apparatus of 500 kHz frequency and transducer were newly developed. The drug permeation studies were performed according to the ultrasound frequencies such as 1 MHz and 500 kHz at $1W/cm^2$ in intensity in continuous mode or pulsed mode, respectively. The results on transdermal permeation of lidocaine according to ultrasound intensity showed that the drug permeation increased as the intensity was higher.
Keywords
Lidocaine; Low Frequency Phonophoresis; Transdermal Permeation;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Tachibana, K. and Tachibana, S., "Transdermal Delivery Ofinsulin by Ultrasonic Vibration," J. Pharm., 43(4), 270-271(1991)   DOI
2 Mitragotri, S. and Kost, J., "Low-Frequency Sonophoresis-a Review," Advanced Drug Delivery Reviews, 56(5), 589-601(2004)   DOI   ScienceOn
3 Gvarishvili, E. P. and Dushin, N. V., "Effect of Superphonoelectrophoresis on Chorioretinal Dystrophy," Vestn. Oftalmol., 115(4), 19-21(1999)
4 Becker, B. M. and Helfrich, S., "Ultrasound with Topical Anesthetic Rapidly Decreases," Pain of Intravenous Cannulation. Acad. Emerg. Med., 12(4), 276-293(2005)
5 McElnay, J. C., Matthews, M. P. and Harland, R., "The Effect of Ultrasound on the Percutaneous Absorption of Lignocaine," Br. J. Clin. Pharmacol,, 20(4), 421-424(1985)   DOI   ScienceOn
6 Kim, M.-J., Kim, Y.-I. and Yang, J.-H., "Formulation Design for Skin Permeation of Lincomycin Cream," Yakhak Hoeji, 47(3), 154-158 (2003)
7 Meidan, V. M., Docker, M. F. and Walmsley, A. D., "Low Intensity Ultrasound as a Probe to Elucidate Therelative Follicular Contribution to Total Transdermal Absorption," Pharm. Res., 15(1), 85-92(1998)   DOI   ScienceOn
8 Yang, J. H., Kim, D. K. and Kim, T. Y., "Anti-inflammatory Effects by Transdermal Application of Triamcinolone Acetonide Gel Using Phonophoresis in Rats," Int. J. Pharm., 302(1-2), 39-46 (2005)   DOI   ScienceOn
9 Monti, D., Gianelli, R. and Chetoni, P., "Comparison of the Effect of Ultrasound and of Chemical Enhancers on Transdermal Permeation of Caffeine and Morphinethrough Hairless Mouse Skin In Vitro," Int. J. Pharm., 229(1-2), 131-137(2001)   DOI   ScienceOn
10 Tezel, A., Sens, A. and Mitragotri, S., "Investigations of the Role of Cavitation in Low-Frequency Sonophoresis Using Acoustic Spectroscopy," J. Pharm. Sci., 91, 444-453(2002)   DOI   ScienceOn
11 Moussatov, A. G., Baker, A. C. and Duck, F. A., "A Possible Approach to the Treatment of Polycystic Ovarian Syndrome Using Focused Ultrasound," Ultrasonics, 36(8), 893-900(1998)   DOI   ScienceOn
12 Zderic, V., Clark, J. I. and Martin, R. W., "Ultrasound-Enhanced Transcorneal Drug Delivery," Cornea Nov., 23(8), 804-11(2004)   DOI   ScienceOn
13 Burry, K. A., Patton, P. E. and Hermsmayer, K., "Percutaneous Absorption of Progesteronein Postmenopausal Women Treated with Transdermal Estrogen," Am. J. Obstet. Gyneco., 180(6 Pt 1), 1504-1511(1999)   DOI   ScienceOn
14 Katz, N. P., Shapiro, D. E. and Herrmann, T. E., "Rapid onset of Cutaneous Anesthesia with EMLA Cream After Pretreatment with a New Ultrasound-Emitting Device," Anesth. Analg., 98(2), 371-6(2004)
15 Zderic, V., Vaezy, S. and Martin, R. W., "Ocular Drug Delivery Using 2-kHz Ultrasound," Ultrasound Med. Biol., 28(6), 823-829(2002)   DOI   ScienceOn
16 Merino, G., Kalia, Y. N. and Guy, R. H., "Ultrasound-Enhanced Transdermal Transport," J. Pharmac. Sci., 92(6), 1125-37(2003)   DOI   ScienceOn
17 Bommannan, D., Menon, G. K. and Okuyuma, H., "Sonophoresis 2. Examination of the Mechanism(s) of Ultrasound Enhanced Transdermal Drug Delivery," Pharm. Res., 9(8), 1043-1047(1992)   DOI
18 Galinkin, J. L., Rose, J. B. and Harris, K., "Lidocaine Iontophoresis Versus Eutectic Mixture of Local Anesthetics (EMLA) for IV Placement in Children," Anesth. Analg., 94(6), 1484-1488 (2002)   DOI
19 Patel, G. M., Chuang, A. Z. and Kiang, E., "Epithelial Healing Rates with Topical Ciprofloxacin, Ofloxacin, and Ofloxacin with Artificial Tears After Photorefractive Keratectomy," J. Cataract Refract Surg., 26(5), 690-694(2000)   DOI   ScienceOn
20 Kozanoglu, E., Basaran, S. and Guzel, R., "Short Term Efficacy of Ibuprofen Phonophoresis Versus Continuous Ultrasound Therapy in Knee Osteoarthritis," Swiss Med. Wkly., 133(23-24), 333-338 (2003)
21 Fang, J. Y., Fang, C. L. and Sung, K. C., "Effect of Low Frequency Ultrasound on the in vitro Percutaneous Absorption of Clobetasol 17-Propionate," J. Pharm., 191(1), 3342(1999)
22 Tang, H., Blankschtein, D. and Langer, R., "An Investigation of the Role of Cavitation in Low-Frequency Ultrasound-Mediated Transdermal Drug Transport," Pharm. Res., 19(8), 1160-1169(2002)   DOI   ScienceOn
23 Williams, A. R., "Phonophoresis-an in vivo Evaluation Using Three Topical Anaesthetic Preparations," Ultrasonics, 28(3), 137-140(1990)   DOI   ScienceOn
24 Wallace, M. S., Ridgeway, B. and Jun, E., "Topical Delivery of Lidocaine in Healthy Volunteers by Electroporation, Electroinc Orporation, or Iontophoresis-an Evaluation of Skin Anesthesia," Reg. Anesth. Pain. Med., 26(3), 229-38(2001)
25 Asano, J., Suisha, F. and Takada, M., "Effect of Pulsed Output Ultrasound on the Transdermal Absorption of Indomethacin From an Ointment in Rats," Biol. Pharm. Bull., 20(3), 288-291(1997)   DOI   ScienceOn
26 Lenart, I. and Auslander, D., "The Effect of Ultrasound Ondiffusion Through Membranes," Ultrasonics, 18(5), 216-218(1980)   DOI   ScienceOn
27 Ciccone, C. D., Leggin, B. G., Callamaro, J. J., "Effects of Ultrasound and Trolamine Salicylate Phonophoresis on Delayed-onset Muscle Soreness," Physical therapy, 71(9), 666-675(1991)   DOI
28 Machet, L. and Boucaud, A., "Phonophoresis-Efficiency, Mech- Anisms and Skin Tolerance," Inter. J. Pharmc., 243(1-2), 1-15(2002)   DOI   ScienceOn
29 Panova, I. G., Fateeva, V. I. and Petrishcheva, T. S., "A Pharmacokinetic Studyof Para-aminobenzoic Acid Administered into the Rabbit Eye by Phonophoresis," Izv. Akad. Nauk. Ser. Biol., Jul-Aug(4), 487-489(1995)