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Release Behaviors of Poly(ε-caprolactone)/Poly(ethyleneimine) Microcapsules Containing Fragrant Oil  

Park, Soo-Jin (Advanced Materials Division, Korea Research Institute of Chemical Technology)
Seok, Su-Ja (Advanced Materials Division, Korea Research Institute of Chemical Technology)
Publication Information
Korean Chemical Engineering Research / v.43, no.4, 2005 , pp. 482-486 More about this Journal
Abstract
The biodegradable poly(${\varepsilon}$-caprolactone)(PCL)/poly(ethylene imine)(PEI) microcapsules containing $Al_2O_3$ and fragrant oil were prepared with different PEI contents. The effects of stirring rate and concentration of the surfactant on the diameter and morphologies of microcapsules were investigated by using scanning electron microscope (SEM). Thermal behaviors were studied by using a differential scanning calorimetry(DSC), and the release behaviors of fragrant oil from microcapsule were characterized by UV/vis. spectrophotometer. As a result, the average particle size of the microcapsules decreased with increasing the stirring rate or concentration of the surfactant. The surface morphologies of the microcapsules were changed from smooth surfaces to skin-like rough surfaces as increasing the PEI content. These results were mainly due to the increased hydrophilic groups at the microcapsule surfaces, resulting in increasing the release rate of fragrant oil in the microcapsules studied.
Keywords
Microcapsule; Fragrant Oil; Poly(${\varepsilon}$-caprolactone); Poly(Ethylene Imine);
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1 O'Donnell, P. B. and McGinity, J. W., 'Preparation of Microspheres by the Solvent Evaporation Technique,' Adv. Drug Del. Rev., 28(1), 25-42(1997)   DOI   ScienceOn
2 Palmieri, G. F., Bonacucina, G., Martino, P. D. and Martelli, S., 'Microencapsulation of Semisolid Ketoprofen/Polymer Microspheres,' Int. J. Pharm., 242(1/2), 175-178(2002)   DOI   ScienceOn
3 Huh, K. M. and Bea, Y. H., 'Synthesis and Characterization of Poly(ethylene glycol)/Poly(L-lactic acid) Alternating Multiblock Copolymers,' Polymer., 40(22), 6147-6155(1999)   DOI   ScienceOn
4 in Lazzi, L. A. and Nixon, J. R., 'Microcapssulation,' 193, Marcel Dekker, New York(1997)
5 Yilmaz, G., Jongboom, R. O. J., Feil, H. and Hennink, W. E., 'Encapsulation of Sunflower Oil in Starch Matrices Via Extrusion: Effect of the Interfacial Properties and Processing Conditions on the Formation of Dispersed Phase Morphologies,' Carbohydrate Polym., 45(4), 403-410(2001)   DOI   ScienceOn
6 Sen, M. and Güven, O., 'Radiation Synthesis of Poly(N-vinyl 2- pyrrolidone/itaconic acid) Hydrogels and their Controlled Release Behaviours,' Radiat. Phys. Chem., 55(2), 113-120(1999)   DOI   ScienceOn
7 Hong, K. J. and Park, S. M., 'Preparation of Polyurea Microcapsules with Different Composition Ratios: Structures and Thermal Properties,' Mater. Sci. Eng. A., 272(2), 418-421(1999)   DOI   ScienceOn
8 Helander, I. M., Alakomi, H. L., Latvakala, K. and Koski, P., 'Polyethyleneimine is an Effective Permeabilizer of Gram-Negative Bacteria,' Microbiology, 143(10), 3193-3199(1997)   DOI   ScienceOn
9 Park, S. J., Shin, Y. S. and Lee, J. R., 'Preparation and Characterization of Microcapsules Containing Lemon Oil,' J. Colloid Interface Sci., 241(2), 502-508(2001)   DOI   ScienceOn
10 Benita, S., Microcapsulation: Method and Industrial Application, Marcel Deker, New York(1997)
11 Xu, X., Yu, H., Gao, S., Ma, H., Leon, K. and Wang, S., 'Polyphosphoester Microspheres for Sustained Release of Biologically Active Nerve Growth Factor,' Biomaterials., 23(17), 3765- 3772(2002)   DOI   ScienceOn
12 Erdem, B., Sudol, E. D., Dimonie, V. L. and El-Aasser, M. S., 'Encapsulation of Inorganic III. Characterization of Encapsulation, ' J. Polym. Sci. Chem., 38(24), 4441-4450(2000)   DOI   ScienceOn
13 Boussif, O., Lezoualc'h, F., Zanta, M. A., Mergny, M. D., Scherman, D., Demeneix, B. and Behr, J. P., 'A Versatile Vector for Gene and Oligonnucleotide Transfer into Cells in Culture and In Vivo: Polyethyleneimine,' Proc. Natl. Acad. Sci. U.S.A., 92(16), 7297-7301(1995)
14 Arriagada, F. J. and Asare, K. O., 'Synthesis of Nanosize Silica in a Nonionic Water-in-Oil Microemulsion: Effects of the Water, Surfactant Molar Ratio and Ammonia Concentration,' J. Colloid and Interface. Sci., 211(2), 210-220(1999)   DOI   ScienceOn
15 Kim, H. K. and Park, T. G., 'Microencapsulation of Dissociable Human Growth Hormone Aggregates within Poly(D,L-lactic-coglycolic acid) Microparticles for Sustained Release,' Int, J. Pharm., 229(1/2), 107-116(2001)   DOI   ScienceOn
16 Shen, Y., Sun, W., Zhu, K. J. and Shen, Z., 'Regullation of Biodegradability and Drug Release Behavior of Aliphatic Polyesters by Blending,' J. Biomed. Mater. Res., 50(4), 528-535(2000)   DOI   ScienceOn
17 Ng, C. S., Teoh, S. H., Chung, T. S. and Hutmacher, D. W., 'Simultaneous Biaxial Drawing of Poly($\varepsilon$-caprolactone) Films,' Polymer., 41(15), 5855-5864(2000)   DOI   ScienceOn
18 Nguyen, H. K., Lemieux, P., Vinogradov, S. V., Gebhart, C. L., Guerin, N., Paradis, G., Bronich, T. K., Alakhov, V. Y. and Kabanov, A. V., 'Evaluation of Polyether-Polyethyleneimine Graft Copolymers as Gene Transfer Agents,' Gene. Ther., 7(2), 126-138(2000)   DOI