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pH-Sensitive Dynamic Swelling Behavior of Glucose-containing Anionic Hydrogels  

Kim, Bumsang (Department of Chemical Engineering, Hongik University)
Publication Information
Korean Chemical Engineering Research / v.43, no.2, 2005 , pp. 299-304 More about this Journal
Abstract
There have been many efforts to use anionic hydrogels as oral protein delivery carriers due to their pH-responsive swelling behavior. The dynamic swelling behavior of poly(methacrylic acid-co-methacryloxyethyl glucoside) [P(MAA-co-MEG)] hydrogels was investigated to determine the mechanism of water transport through these anionic hydrogels. The exponential relation $M_t/M_{\infty}=kt^n$ was used to calculate the exponent, n, describing the Fickian or non-Fickian behavior of swelling polymer networks. The mechanism of water transport through these gels was significantly affected by the pH of the swelling medium. The mechanism of water transport became more relaxation-controlled in the swelling medium of pH 7.0 that was higher than the $pK_a$ of the gels. Experimental results of time-dependent swelling behavior of the gels were analyzed with several mathematical models. Using ATR-FTIR spectroscopy, the effect of ionization of the carboxylic acid groups in the polymer networks on the water transport mechanism was investigated.
Keywords
Anionic Hydrogel; pH-Sensitive Swelling; Water Transport Mechanism; Drug Delivery Systems:;
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Times Cited By KSCI : 1  (Citation Analysis)
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