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http://dx.doi.org/10.13045/acupunct.2016041

Factors associated with willingness to participate in clinical trials for cancer patients: an exploratory narrative review  

Kim, Kun Hyung (School of Korean Medicine, Pusan National University Hospital)
Hwang, Bo Yown (School of Korean Medicine, Pusan National University Hospital)
Son, Gyung Mo (Department of Surgery, Pusan National University Yangsan Hospital)
Publication Information
Journal of Acupuncture Research / v.33, no.3, 2016 , pp. 145-152 More about this Journal
Abstract
Objectives : This study aimed to investigate both cancer patients' willingness to participate (WTP) in clinical trials and its associated factors. Methods : We searched MEDLINE (PubMed) for studies that had investigated cancer patients' WTP in clinical trials. Search terms included 'willingness to participate', 'cancer' and 'trial'. Studies published within the last five years up to July 26, 2016 were potentially eligible. Results : Of 44 initial hits, 14 studies (12 quantitative and 2 qualitative) were included. Two out of the 14 studies investigated WTP in an acupuncture trial. Study designs, such as WTP measurement methods, investigation settings, and type of cancer, varied. The proportion of participants with a WTP was widely distributed between the studies (median 48.6 %, range 11.1 % to 88.3 %). Factors associated with WTP included various socio-demographic factors, clinical factors, participants' knowledge/attitudes toward clinical trials, travel distance, information from physicians, and trust toward physicians. Conclusion : WTP and its associated factors were variable across the reviewed studies, which might be due to different research methods and contexts. Whether or not common factors associated with cancer patients' WTP in clinical trials exist remains unclear and thus warrants further research.
Keywords
Willingness to participate; Cancer; Clinical trial; Literature review;
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1 Chen X, Deng L, Jiang X et al. Chinese herbal medicine for oesophageal cancer. Cochrane Database Syst Rev. 2016 ; 22(1) : CD004520.
2 Mills EJ, Seely D, Rachlis B et al. Barriers to participation in clinical trials of cancer: a metaanalysis and systematic review of patient-reported factors. Lancet Oncol. 2006 ; 7(2) : 141-8.   DOI
3 Byrne MM, Tannenbaum SL, Gluck S et al. Participation in cancer clinical trials: why are patients not participating? Med Decis Making. 2014 ; 34(1) : 116-26.   DOI
4 Gollhofer SM, Wiskemann J, Schmidt ME et al. Factors influencing participation in a randomized controlled resistance exercise intervention study in breast cancer patients during radiotherapy. BMC Cancer. 2015 ; 15 : 186.   DOI
5 Igwe E, Woodburn J, Davolos J et al. Patientperceptions and willingness to participate in clinical trials. Gynecol Oncol. 2016 ; 142(3) : 520-4   DOI
6 Kaplan CP, Napoles AM, Narine S et al. Knowledge and attitudes regarding clinical trials and willingness to participate among prostate cancer patients. Contemp Clin Trials. 2015 ; 45(Pt B) : 443-8.   DOI
7 Lee SJ, Park LC, Lee J et al. Unique perception of clinical trials by Korean cancer patients. BMC Cancer. 2012 ; 12 : 594.   DOI
8 Mao JJ, Tan T, LiS Q et al. Attitudes and barriers towards participation in an acupuncture trial among breast cancer patients: a survey study. BMC Complement Altern Med. 2014 ; 14 : 7.   DOI
9 Mc Grath-Lone L, Day S, Schoenborn C et al. Exploring research participation among cancer patients: analysis of a national survey and an indepth interview study. BMC Cancer. 2015 ; 15 : 618.   DOI
10 Moorcraft SY, Marriott C, Peckitt C et al. Patients' willingness to participate in clinical trials and their views on aspects of cancer research: results of a prospective patient survey. Trials. 2016 ; 17 : 17.   DOI
11 Grudzen CR, Richardson LD, Kandarian B et al. Barriers to palliative care research for emergency department patients with advanced cancer. J Community Support Oncol. 2014 ; 12(5) : 158-62.   DOI
12 Wisinski KB, Faerber A, Wagner S et al. Predictors of willingness to participate in windowof-opportunity breast trials. Clin Med Res. 2013 ; 11(3) : 107-12.   DOI
13 Schapira MM, Mackenzie ER, Lam R et al. Breast cancer survivors willingness to participate in an acupuncture clinical trial: a qualitative study. Support Care Cancer. 2014 ; 22(5) : 1207-15.   DOI
14 Shah A, Efstathiou JA, Paly JJ et al. Prospective preference assessment of patients' willingness to participate in a randomized controlled trial of intensity-modulated radiotherapy versus proton therapy for localized prostate cancer. Int J Radiat Oncol Biol Phys. 2012 ; 83(1) : e13-9.   DOI
15 Adams RN, Mosher CE, Blair CK et al. Cancer survivors' uptake and adherence in diet and exercise intervention trials: an integrative data analysis. Cancer. 2015 ; 121(1) : 77-83.   DOI
16 Ammari AB, Hendriksen C, Rydahl-Hansen S. Recruitment and Reasons for Non-Participahttption in a Family-Coping-Orientated Palliative Home Care Trial (FamCope). J Psychosoc Oncol. 2015 ; 33(6) : 655-74.   DOI
17 Zammar G, Meister H, Shah J et al. So different, yet so similar: meta-analysis and policy modeling of willingness to participate in clinical trials among Brazilians and Indians. PloS One. 2010 ; 5(12) : e14368.   DOI
18 Cao H, Mu Y, Li X et al. A Systematic Review of Randomized Controlled Trials on Oral Chinese Herbal Medicine for Prostate Cancer. PloS One. 2016 ; 11(8) : e0160253.   DOI
19 Garcia MK, McQuade J, Haddad R et al. Systematic review of acupuncture in cancer care: a synthesis of the evidence. J Clin Oncol. 2013 ; 31(7) : 952-60.   DOI