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http://dx.doi.org/10.13045/acupunct.2015029

The Effect of Poria Cocos Pharmacopuncture at SP6(Sameumgyo) and ST36(Joksamni) on Chronic Stress Model(CSM) Rats  

Kim, Seon Wook (Department of Acupuncture and Moxibustion Medicine, College of Oriental Medicine, Dongshin University)
Kim, Jae Hong (Department of Acupuncture and Moxibustion Medicine, College of Oriental Medicine, Dongshin University)
Cho, Myoung Rae (Department of Acupuncture and Moxibustion Medicine, College of Oriental Medicine, Dongshin University)
Shin, Jeong Cheol (Department of Acupuncture and Moxibustion Medicine, College of Oriental Medicine, Dongshin University)
Publication Information
Journal of Acupuncture Research / v.32, no.2, 2015 , pp. 187-195 More about this Journal
Abstract
Objectives : The purpose of this study is evaluating the effect of Poria cocos pharmacopuncture (PCP) at $SP_6$(Sameumgyo) and $ST_{36}$(Joksamni) on chronic stress model(CSM) rats. Methods : The experimental rats were assigned to five groups: normal, CSM(control), PCP1X, PCP2.5X and PCP5X. The experimental rats in CSM(control), PCP1X, PCP2.5X and PCP5X were put through a timetable to cause CSM. PCP($20{\mu}l$) was administered at $SP_6$, $ST_{36}$ to groups PCP1X, PCP2.5X and PCP5X once every three days for a total of six times. The weight of the rats was measured by an electronic scale after PCP injection, once every three days for a total of six times. Blood samples were taken from the rats for analysis of aspartate aminotransferase(AST) and alanine aminotransferase(ALT). Serotonin and norepinephrine were measured by enzyme-linked immunosorbent assay(ELISA) kit. Results : The experimental groups(PCP1X, 2.5X, 5X) showed significant body weight increase compared to the control group. Regarding AST and ALT changes in serum, the experimental groups(PCP2.5X, 5X) showed a significant decrease compared to the control group. For Serotonin changes in serum, the experimental group(PCP5X) showed a significant increase compared to the control group. For Norepinephrine changes in serum, the experimental groups(PCP2.5X) showed a significant decrease compared to the control group. Conclusions : These data suggest that PCP at $SP_6$, $ST_{36}$ has therapeutic effects on CSM rats.
Keywords
Chronic stress model; Poria cocos; Pharmacopuncture; $SP_6$(Sameumgyo); $ST_{36}$(Joksamni);
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Times Cited By KSCI : 5  (Citation Analysis)
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