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http://dx.doi.org/10.13045/acupunct.2015005

Effects of Curculiginis Rhizoma Pharmaco-Acupuncture at $ST_{36}$ on Monosodium Iodoacetate(MIA)-induced Osteoarthritic Rats  

Ji, Min Jung (Department of Acupuncture & Moxibustion, Meridian & Acupoint, College of Oriental Medicine, Deagu Haany University)
Lim, Seong Chul (Department of Acupuncture & Moxibustion, Meridian & Acupoint, College of Oriental Medicine, Deagu Haany University)
Kim, Jae Soo (Department of Acupuncture & Moxibustion, Meridian & Acupoint, College of Oriental Medicine, Deagu Haany University)
Lee, Hyun Jong (Department of Acupuncture & Moxibustion, Meridian & Acupoint, College of Oriental Medicine, Deagu Haany University)
Lee, Yun Kyu (Department of Acupuncture & Moxibustion, Meridian & Acupoint, College of Oriental Medicine, Deagu Haany University)
Publication Information
Journal of Acupuncture Research / v.32, no.1, 2015 , pp. 53-66 More about this Journal
Abstract
Objectives : This study was designed to investigate effects of Curculiginis Rhizoma pharmaco-acupuncture at $ST_{36}$ on monosodium iodoacetate-induced osteoarthritic rats. Methods : Twenty rats were divided into four groups consisting of 5 rats: rats receiving no injection(normal), rats injected with monosodium Iodoacetate(MIA, control), rats injected with MIA and normal saline(N-S), and rats injected with MIA and Curculiginis Rhizoma (CRPA). N-S and CRPA were administered once a day at $ST_{36}$ during 21 days. After that we examined the weight-bearing ability of hind paws, liver and kidney function, immunocell, cytokines, proteins, and gene expression of cytokines. Injury of synovial tissue was measured by H & E, Safranin O immunofluorescence. Results : The weight-bearing ability of the hind paws, Serum TNF-${\alpha}$, IL-$1{\beta}$, IL-6, PGE2, LTB4, DPD, Osteocalcin, Protein COX-2 of CRPA decreased significantly. Protein Arachidonate 5 lipoxygenase of CRPA was decreased, but not significantly. Expression of gene COX-2, TNF-${\alpha}$, IL-$1{\beta}$, IL-6, NOS2 of CRPA decreased. In histological observations, CRPA was improved, compared with other control groups. Conclusions : It can be suggested that Curculiginis Rhizoma pharmaco-acupuncture at $ST_{36}$ has anti-inflammatory and pain relief effects on monosodium iodoacetate-induced osteoarthritic rats.
Keywords
Curculiginis Rhizoma pharmaco-acupuncture; Osteoarthritis; Monosodium iodoacetate(MIA); $ST_{36}$;
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Times Cited By KSCI : 5  (Citation Analysis)
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