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http://dx.doi.org/10.13045/acupunct.2014023

The Effect of Tokoro Rhizoma Pharmacopuncture at $KI_{10}$ in Lipopolysaccharide Induced Acute Nephritis in Rats  

Kim, Yun Joo (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Daejeon University)
Kang, Jae Hui (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Daejeon University)
Lee, Hyun (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Daejeon University)
Publication Information
Journal of Acupuncture Research / v.31, no.2, 2014 , pp. 39-50 More about this Journal
Abstract
Objectives : This study was designed to evaluate the effects of Tokoro Rhizoma pharmat $KI_{10}$ in nephritis induced by lipopolysaccharide(LPS) in rat. Methods : Rats were divided into 4 groups and 3 groups(LPS, saline, Tokoro Rhizoma pharmacopuncture(TR-P) group) were injected LPS to induce nephritis. TR-P group was treated with TR at $KI_{10}$ three times for a week, saline group with normal saline. To evaluate the effects of TR at $KI_{10}$ on nephritis in rats, white blood cell(WBC), neutrophil in blood, creatinine, cytokine-induced neutrophil chemoattractant-1(CINC-1) in serum and urinary volume, creatinine in urine, renal myeloperoxidase(MPO) were measured and renal tissue was analyzed. Results : TR-P group significantly reduced WBC, neutrophil in blood, creatinine, CINC-1 in serum, creatinine in urine and renal MPO than LPS group. TR-P group increased urinary volume but, not significant. Conclusion : TR at $KI_{10}$ has a therapeutic effect on nephritis in LPS stimulated rat. Therefore, it is suggested that TR at $KI_{10}$ may be an useful therapeutics for nephritis in clinical field after further researches.
Keywords
Tokoro Rhizoma; Nephritis; Pharmacopuncture; $KI_{10}$; LPS;
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