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http://dx.doi.org/10.13045/acupunct.2014030

Inhibitory Effects of Filiform Acupuncture and Laser Acupuncture at the Points of Zhongzhu($TE_3$).Zulinqi($GB_{41}$) on Neuropathic Pain in the Tibial and Sural Nerve Injury-induced Rats  

Lee, Ju Hee (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University)
Lee, Dong Geun (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University)
Lee, Ook Jae (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University)
Lee, Sang Hyun (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University)
Lee, Jung Hun (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University)
Jeong, Joo Yong (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University)
Cheong, Min Seong (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University)
Yang, Tae Jun (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University)
Kim, Seon Wook (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University)
Cho, Myoung Rae (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University)
Publication Information
Journal of Acupuncture Research / v.31, no.2, 2014 , pp. 119-134 More about this Journal
Abstract
Objectives : The purpose of this study was to investigate the analgesic effects of filiform acupuncture and laser acupuncture at the points of $TE_3{\cdot}GB_{41}$ in neuropathic pain induced rats. Methods : Neuropathic pain in rats was induced by partial resection of the tibial and sural nerves. Three weeks after the neuropathic surgery, each of the experimental groups(AT, LAT, AT + LAT and LAT + AT) was injected at the $TE_3{\cdot}GB_{41}$ twice per week for three weeks. Results : 1. All of the experimental groups(AT, LAT, AT + LAT and LAT + AT) showed a significant decrease in the plantar withdrawal response of allodynia and the thermal allodynia as compared with the control group. During the early phase, the AT and AT + LAT groups have been marked as more significant than the LAT + AT and LAT groups. 2. The expression of c-Fos significantly decreased in the LAT and LAT + AT groups as compared with the control group. 3. The LAT + AT group showed a significant decrease in Bax as compared with the control group. In each experimental groups(AT, LAT, AT + LAT and LAT + AT), Bcl-2 increased and Bax/Bcl-2 ratio decreased as compared with the control group. 4. The LAT, AT + LAT and LAT + AT groups showed a significant increase in mGluR5 as compared with the control group. Conclusions : These results represented that the filiform acupuncture and laser acupuncture at the $TE_3{\cdot}GB_{41}$ exerted anti-apoptotic and neuroprotective effects on the model of neuropathic pain, thereby suggesting that they should be available for decreasing mechanical allodynia.
Keywords
Zhongzhu ($TE_3$); Zulinqi ($GB_{41}$); Neuropathic pain; Acupuncture; Laser acupuncture;
Citations & Related Records
Times Cited By KSCI : 9  (Citation Analysis)
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