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http://dx.doi.org/10.13045/acupunct.2014006

The Effect of Alismatis Rhizoma Herbal-acupuncture at $KI_{10}$ on LPS-induced Nephritis in Rats  

Han, Je Geun (Department of Meridian and Acupoint, College of Korean Medicine, Daejeon University)
Kim, Yang Seob (Department of Meridian and Acupoint, College of Korean Medicine, Daejeon University)
Kim, Byung Soo (Department of Meridian and Acupoint, College of Korean Medicine, Daejeon University)
Yim, Yun Kyoung (Department of Meridian and Acupoint, College of Korean Medicine, Daejeon University)
Publication Information
Journal of Acupuncture Research / v.31, no.1, 2014 , pp. 51-60 More about this Journal
Abstract
Objectives : This study aimed to evaluate the effects of Alismatis Rhizoma Herbal-acupuncture( AR-HA) at $KI_{10}$(Umgok) on nephritis induced by lipopolysaccharide(LPS) in rat. Methods : Rats were injected with LPS to induce nephritis. The rats in $KI_{10}$-AR-HA group were treated with AR-HA, $KI_{10}$-NP group with needle prick, $KI_{10}$-saline group with normal saline injection respectively at $KI_{10}$ three times for a week. Several experimental items were performed including measurements of the numbers of RBC, WBC, neutrophil in blood, the levels of creatinine, $TNF-{\alpha}$, CINC-1 in serum, creatinine, total protein in urine, MPO in kidney. Results : Needle prick stimulation at $KI_{10}$ significantly reduced WBC in blood of LPS-stimulated rats. Saline injection at $KI_{10}$ significantly reduced WBC in blood, $TNF-{\alpha}$ in serum, total protein in urine of LPS-stimulated rats. AR-HA at $KI_{10}$ significantly reduced WBC, neutrophil in blood, $TNF-{\alpha}$, CINC-1 in serum, creatinine, total protein in urine of LPS-stimulated rats. Conclusion : AR-HA at $KI_{10}$ has a therapeutic effect on nephritis in LPS-stimulated rat. There may be a synergism between $KI_{10}$(Umgok) stimulation and AR-HA solution.
Keywords
Nephritis; Herbal-acupuncture; $KI_{10}$; Alismatis Rhizoma;
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