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http://dx.doi.org/10.13045/acupunct.2013012

Effects of Electro and Laser Acupuncture Treatment with $GB_{39}$ and $GB_{34}$ on Neuropathic Pain in Rats Induced by Tibial and Sural Nerve Ligation  

Kim, Yong Se (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Dong-shin University)
Lee, Ju Hee (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Dong-shin University)
Lee, Sang Hyun (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Dong-shin University)
Na, Chang Su (Department of Meridian & Acupoint, College of Korean Medicine, Dong-shin University)
Cho, Myoung Rae (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Dong-shin University)
Publication Information
Journal of Acupuncture Research / v.30, no.3, 2013 , pp. 125-134 More about this Journal
Abstract
Objectives : We studied the effects of electro and laser acupuncture treatment with $GB_{39}$ and $GB_{34}$ on neuropathic pain in rats induced by tibial and sural nerve ligation. Methods : To produce the model of neuropathic pain, the tibial and sural nerves of rats were ligated by a 6-0 silk thread. Three days after the neuropathic surgery, only electro acupuncture(EA), electro acupuncture and 830 nm laser acupuncture(EA-LA-1), and electro acupuncture and 904 nm laser acupuncture(EA-LA-2) were treated with $GB_{39}$ and $GB_{34}$ twice a week for 8 weeks. We observed the withdrawal response of neuropathic rats' legs by von Frey filament and acetone stimulation. We also observed c-fos and nocieptin on the central gray area in the midbrain of neuropathic rats. Results : As we observed the effect of mechanical allodynia, the EA and EA-LA-1 groups in 5 and 6 weeks and the EA-LA-2 group in 6 weeks increased significantly compared with the control group. As for the effect of c-fos activity in the central gray region, the EA, EA-LA-1, and EA-LA-2 groups decreased significantly compared with the control group. The EA-LA-2 group increased significantly compared with the control group as regards the effect of nociceptin activity in the central gray region. Conclusions : We noticed the synergic effect of electro and laser acupuncture treatment because the EA-LA-1 and EA-LA-2 groups had more controllable effect compared with the control group. This study can be used in clinical therapy for neuropathic pain.
Keywords
Neuropathic pain; Electro acupuncture; 830 nm & 904 nm laser acupuncture; $GB_{34}$ & $GB_{39}$; c-Fos; Nociceptin;
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