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The Effect of Junci Medulla Herbal-acupuncture at $KI_{10}$ on LPS induced Nephritis in Rats  

Ihm, Jee Soon (Dept. of Meridian and Acupoint, College of Oriental Medicine, Daejeon University)
Cho, Tae Hwan (Dept. of Meridian and Acupoint, College of Oriental Medicine, Daejeon University)
Yim, Yun Kyoung (Dept. of Meridian and Acupoint, College of Oriental Medicine, Daejeon University)
Publication Information
Journal of Acupuncture Research / v.29, no.6, 2012 , pp. 73-83 More about this Journal
Abstract
Objectives : This study aimed to evaluate the effects of Junci Medulla Herbal-acupuncture(JM-HA) at $KI_{10}$(Umgok) on nephritis induced by lipopolysaccharide(LPS) in rats. Methods : Rats with nephritis induced by LPS, were treated with JM-HA at $KI_{10}$ 3 times a week. The rats in the NP group and the saline group were treated with a needle prick and a saline injection respectively. To evaluate the effects of JM-HA at $KI_{10}$ on nephritis in rats, WBC, neutrophils in blood, BUN, creatinine, TNF-${\alpha}$ in serum, creatinine, total protein in urine and renal MPO were measured. Results : JM-HA at $KI_{10}$ significantly inhibited the increase of WBC and neutrophils in blood, BUN, creatinine, TNF-${\alpha}$ in serum, and MPO in kidney of LPS-stimulated rats. Conclusion : JM-HA at $KI_{10}$ has therapeutic effects on nephritis in LPS-stimulated rats. Therefore, it is suggested that JM-HA at $KI_{10}$ may be a useful therapy in clinical field after further researches.
Keywords
nephritis; herbal-acupuncture; $KI_{10}$; Junci Medulla; LPS;
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