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http://dx.doi.org/10.5714/CL.2012.13.3.173

Temperature and pH-Responsive Release Behavior of PVA/PAAc/PNIPAAm/MWCNTs Nanocomposite Hydrogels  

Jung, Gowun (Department of Fine Chemical Engineering and Applied Chemistry, BK21-E2M, Chungnam National University)
Yun, Jumi (Department of Fine Chemical Engineering and Applied Chemistry, BK21-E2M, Chungnam National University)
Kim, Hyung-Il (Department of Fine Chemical Engineering and Applied Chemistry, BK21-E2M, Chungnam National University)
Publication Information
Carbon letters / v.13, no.3, 2012 , pp. 173-177 More about this Journal
Abstract
A drug delivery system (DDS) was prepared with a temperature and pH-responsive hydrogel. Poly(vinyl alcohol) (PVA)/poly(acrylic acid) (PAAc)/poly(N-isopropylacrylamide) (PNIPAAm)/multi-walled carbon nanotube (MWCNT) nanocomposites were prepared by radical polymerization for the temperature and pH-responsive hydrogels. MWCNTs were employed to improve both the thermal conductivity and mechanical properties of the PVA/PAAc/PNIPAAm/MWCNT nanocomposite hydrogels. Various amounts of MWCNTs (0, 0.5, 1 and 3 wt%) were added to the nanocomposite hydrogels. PVA/PAAc/PNIPAAm/MWCNT nanocomposite hydrogels were characterized with a scanning electron microscope. The mechanical properties were measured with a universal testing machine. Swelling and releasing properties of nanocomposite hydrogels were investigated at various temperatures and pHs. Temperature and pH-responsive release behavior was found to be dependent on the content of MWCNTs in nanocomposite hydrogels.
Keywords
carbon nanotubes; temperature-responsive; pH-responsive; hydrogel; drug release;
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1 Phipps JB, Scott ER, Gyory JR, Padmanabhan RV. Iontophoresis. In: Swarbrick J, Boylan JC, eds. Encyclopedia of Pharmaceutical Technology. 2nd ed., Marcel Dekker, New York, 1573 (2002).
2 Davidson A, Al-Qallaf B, Das DB. Transdermal drug delivery by coated microneedles: Geometry effects on effective skin thickness and drug permeability. Chem Eng Res Des, 86, 1196 (2008). http:// dx.doi.org/10.1016/j.cherd.2008.06.002.   DOI   ScienceOn
3 Carson HJ, Knight LD, Dudley MH, Garg U. A fatality involving an unusual route of fentanyl delivery: chewing and aspirating the transdermal patch. Legal Med, 12, 157 (2010). http://dx.doi. org/10.1016/j.legalmed.2010.03.001.   DOI   ScienceOn
4 Schulz M, Fussnegger B, Bodmeier R. Influence of adsorbents in transdermal matrix patches on the release and the physical state of ethinyl estradiol and levonorgestrel. Eur J Pharm Biopharm, 77, 240 (2011). http://dx.doi.org/10.1016/j.ejpb.2010.11.011.   DOI   ScienceOn
5 Hirokawa Y, Tanaka T. Volume phase transition in a nonionic gel. J Chem Phys, 81, 6379 (1984). http://dx.doi.org/10.1063/1.447548.   DOI
6 Hoffman AS. Applications of thermally reversible polymers and hydrogels in therapeutics and diagnostics. J Controlled Release, 6, 297 (1987). http://dx.doi.org/10.1016/0168-3659(87)90083-6.   DOI   ScienceOn
7 Don TM, Chen HR. Synthesis and characterization of AB-crosslinked graft copolymers based on maleilated chitosan and N-isopropylacrylamide. Carbohydr Polym, 61, 334 (2005). http://dx.doi. org/10.1016/j.carbpol.2005.05.025.   DOI   ScienceOn
8 Tanaka T. Phase transitions in gels and a single polymer. Polymer, 20, 1404 (1979). http://dx.doi.org/10.1016/0032-3861(79)90281- 7.   DOI   ScienceOn
9 Yan Q, Hoffman AS. Synthesis of macroporous hydrogels with rapid swelling and deswelling properties for delivery of macromolecules. Polymer, 36, 887 (1995). http://dx.doi.org/10.1016/0032- 3861(95)93123-4.   DOI   ScienceOn
10 Khare AR, Peppas NA. Swelling/deswelling of anionic copolymer gels. Biomaterials, 16, 559 (1995). http://dx.doi.org/10.1016/0142- 9612(95)91130-q.   DOI   ScienceOn
11 Ilavsky M. Phase transition in swollen gels. 2. Effect of charge concentration on the collapse and mechanical behavior of polyacrylamide networks. Macromolecules, 15, 782 (1982). http://dx.doi. org/10.1021/ma00231a019.   DOI
12 Heskins M, Guillet JE. Solution properties of poly(N-isopropylacrylamide). J Macromol Sci A: Chem, 2, 1441 (1968). http:// dx.doi.org/10.1080/10601326808051910.   DOI
13 Tanaka Y, Kagami Y, Matsuda A, Osada Y. Thermoreversible transition of tensile modulus of hydrogel with ordered aggregates. Macromolecules, 28, 2574 (1995). http://dx.doi.org/10.1021/ ma00111a062.   DOI   ScienceOn
14 Aoki T, Kawashima M, Katono H, Sanui K, Ogata N, Okano T, Sakurai Y. Temperature-responsive interpenetrating polymer networks constructed with poly(acrylic acid) and poly(N,N-dimethylacrylamide). Macromolecules, 27, 947 (1994). http://dx.doi. org/10.1021/ma00082a010.   DOI
15 Yun J, Im JS, Lee YS, Kim HI. Electro-responsive transdermal drug delivery behavior of PVA/PAA/MWCNT nanofibers. Eur Polym J, 47, 1893 (2011). http://dx.doi.org/10.1016/j.eurpolymj. 2011.07.024.   DOI   ScienceOn
16 Hassan C, Peppas N. Structure and applications of poly(vinyl alcohol) hydrogels produced by conventional crosslinking or by freezing/thawing methods. Adv Polym Sci, 153, 37 (2000). http:// dx.doi.org/10.1007/3-540-46414-x_2.   DOI
17 Lee JW, Kim SY, Kim SS, Lee YM, Lee KH, Kim SJ. Synthesis and characteristics of interpenetrating polymer network hydrogel composed of chitosan and poly(acrylic acid). J Appl Polym Sci, 73, 113 (1999). http://dx.doi.org/10.1002/(sici)1097- 4628(19990705)73:1<113::aid-app13>3.0.co;2-d.   DOI
18 Chen L, Xie H. Surfactant-free nanofluids containing double- and single-walled carbon nanotubes functionalized by a wet-mechanochemical reaction. Thermochim Acta, 497, 67 (2010). http://dx.doi. org/10.1016/j.tca.2009.08.009.   DOI   ScienceOn
19 Park OK, Jeevananda T, Kim NH, Kim Si, Lee JH. Effects of surface modification on the dispersion and electrical conductivity of carbon nanotube/polyaniline composites. Scripta Mater, 60, 551 (2009). http://dx.doi.org/10.1016/j.scriptamat.2008.12.005.   DOI   ScienceOn
20 Jeon S, Yun J, Lee YS, Kim HI. Preparation of poly(vinyl alcohol)/ poly(acrylic acid)/TiO2/carbon nanotube composite nanofibers and their photobleaching properties. J Ind Eng Chem, 18, 487 (2012). http://dx.doi.org/10.1016/j.jiec.2011.11.068.   DOI   ScienceOn