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http://dx.doi.org/10.9799/ksfan.2019.32.2.138

Antioxidative Activities and Inhibitory Effects on Lipid Accumulation of Extracts from Different Parts of Morus alba and Cudrania tricuspidata  

Kim, Gun-Hee (Dept. of Food and Nutrition, Duksung Women's University)
Kim, Eunhyang (Dept. of Food and Nutrition, Duksung Women's University)
Publication Information
The Korean Journal of Food And Nutrition / v.32, no.2, 2019 , pp. 138-147 More about this Journal
Abstract
In this study, we examined antioxidative effects and the anti-adipogenesis effect of different parts of Cudrania tricuspidata (C), and Morus alba (M). Total polyphenol contents were highest in M-root ($34.56{\pm}0.045mg\;GAE/g$), and there was no significant difference, between C-root and M-leaf. Total flavonoid contents of C-root were highest ($23.07{\pm}0.004mg\;QE/g$). To examine antioxidant activities of C and M extracts, DPPH and ABTS radical scavenging activity, and FRAP assay, was used. Results show that antioxidant activities of C and M extracts increased, in a dose-dependent manner. Adipocytes are generated by preadipocyte differentiation, during adipogenesis. Matured adipocytes accumulate in abnormal and cause obesity. We investigated effects of leaf and root extracts of C and M, on lipid accumulation, in 3T3-L1 adipocytes. Changes in cell morphology, and degrees of lipid accumulation in adipocytes, were evaluated by Oil Red O staining. Root extracts of C and M, reduced lipid content in a dose-dependent manner. Therefore, root extracts of C and M, may be good candidates for managing obesity.
Keywords
Cudrania tricuspidata; Morus alba; antioxidative activity; 3T3-L1; adipogenesis;
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