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http://dx.doi.org/10.9799/ksfan.2015.28.3.343

Screening of Anti-Inflammatory Herbs having the Activation of MAPK Family Proteins  

Lee, Keyong Ho (Chong Kun Dang Pharm.)
Rhee, Ki-Hyeong (College of Industrial Sciences, Kongju National University)
Publication Information
The Korean Journal of Food And Nutrition / v.28, no.3, 2015 , pp. 343-350 More about this Journal
Abstract
The aim of this study was to evaluate the potential anti-inflammorty properties of herbs via MAPKs such as ERK, p38, JNK. Fifty-one kinds of each herbal medicine, that were extracted with ethanol, were used in the inhibitory assay of cytokine (TNF-${\alpha}$, IL-$1{\beta}$ and IL-6) and NO. of these, 10 species of herbal medicines, Angelica dahurica, Atractylodes lancea, Cnidium officinale, Duchesnea chrysantha, Oldenlandia diffusa, Lonicera japonica, Paeonia lactiflora, Pinus thunbergii, Rehmannia glutinosa and Rubus coreanus, were screened as potential inhibitors (< $300{\mu}g/mL$) of NO, TNF-${\alpha}$, IL-$1{\beta}$ and IL-6. Among the 10 species, Lonicera japonica showed potential anti-inflammatory effects Lonicera japonica extract of $200{\mu}g/mL$ inhibited the phosphorylation of ERK, p38 and JNK. In addition, Lonicera japonica extract at 20 mg/kg increased survival rate from LPS-induced endotoxin shock by 3 fold.
Keywords
ERK; p38; JNK; Lonicera japonica; endotoxin shock;
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Times Cited By KSCI : 6  (Citation Analysis)
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